Healthcare,
Journal Year:
2024,
Volume and Issue:
12(18), P. 1879 - 1879
Published: Sept. 19, 2024
Objectives:
Controlling
the
lifestyle
associated
with
dementia
risk
can
delay
process
of
cognitive
decline.
Subjective
decline
(SCD)
and
mild
impairment
(MCI)
are
early
states
in
development
also
window
period
for
intervention
dementia.
The
purpose
this
study
was
to
explore
association
between
multi-domain
objective
elderly
people
SCD
MCI
Chinese
communities
provide
reference
effective
implementation
precise
health
management
measures
reduce
Methods:
A
total
265
middle-aged
volunteers
recruited
from
community
were
divided
into
group
(107
cases),
(80
healthy
control
(HC)
(78
cases).
All
participants
received
clinical
interview,
examination,
assessments.
Results:
Dementia
Risk
Reduction
Lifestyle
Scale
(DRRLS)
scores
HC,
SCD,
groups
[110.00
(11.25)
vs.
101.00
(10.00)
79.50
(20.75)]
exhibited
statistically
significant
differences
among
them.
score
DRRLS
showed
a
negative
correlation
Trail-Making
Test
(TMT),
positive
correlations
both
Verbal
Fluency
(VFT)
Auditory
Learning
(AVLT)
(p
<
0.05).
After
adjusting
confounding
factors,
such
as
age
years
education,
multiple
linear
regression
analysis
revealed
several
points.
In
group,
brain-strengthening
exercise
interpersonal
relationship
negatively
correlated
TMT
(β
=
−11.257,
−15.077;
all
p
0.05),
while
responsibility,
smoking
behavior,
positively
AVLT
0.485,
0.344,
0.406;
Group,
exercise,
brain-healthy
diet,
−22.011,
−16.206,
−11.696;
0.01),
whereas
mental
activity,
relationship,
stress
0.450,
0.435,
0.308,
0.256,
0.607;
Conclusions:
communities,
unhealthy
individuals
is
significantly
function
impairment.
greater
their
habits,
more
pronounced
scope
severity
becomes.
Furthermore,
different
dimensions
have
varying
impacts
on
domains.
Frontiers in Microbiology,
Journal Year:
2025,
Volume and Issue:
16
Published: May 27, 2025
Background
Cognitive
impairment
is
a
decline
in
people’s
ability
to
think,
learn,
and
remember,
which
has
some
impact
on
an
individual’s
daily
activities
or
social
functioning.
Microbial
toxins
metabolites
from
dysregulated
gut
microbiota
directly
interact
with
the
intestinal
epithelium.
This
interaction
triggers
neuroinflammation
neurodegeneration
central
nervous
system,
ultimately
impairing
cognitive
function.
It
been
found
that
modulation
of
flora
can
be
effective
intervention
improve
dysfunction.
study
first
summarize
outline
global
research
status
trends
this
field
bibliometric
perspective,
providing
reference
guidance
for
future
field.
Methods
Based
Web
Science
Core
Collection
(WoSCC)
database,
Literature
published
between
1999–2025
was
searched.
Bibliometric
analysis
performed
using
VOSviewer
CiteSpace
software
analyze
data
countries,
institutions,
authors,
journals,
keywords,
citations,
generate
visual
maps.
Results
A
total
1,702
pieces
related
literature
were
retrieved.
The
overall
trend
publication
increasing.
China
largest
number
papers,
Huazhong
University
&
Technology
Kim,
Dong-Hyun
institutions
individuals
more
publications.
most
frequently
cited
journal
SCI
REP-UK
.
frequent
keywords
are
microbiota,
followed
by
Alzheimer’s
disease,
impairment,
Brain,
oxidative
stress
Inflammation.
Conclusion
In
recent
years,
application
treatment
made
remarkable
progress.
Oxidative
inflammatory
response
have
become
main
hotspots
patients.
gut-brain
axis
plays
important
role
mechanism
action.
Short-chain
fatty
acids
focus
microbial
metabolism.
Fecal
transplantation
technology
increasingly
being
used
as
emerging
method
flora.
Modifying
modifying
diet
exercise
may
strategy
prevent
dysfunction
future.
Future
studies
gender
differences
Sports,
Journal Year:
2024,
Volume and Issue:
12(2), P. 57 - 57
Published: Feb. 13, 2024
Addressing
cognitive
impairment
(CI)
represents
a
significant
global
challenge
in
health
and
social
care.
Evidence
suggests
that
aging
metabolic
disorders
increase
the
risk
of
CI,
yet
promisingly,
physical
exercise
has
been
identified
as
potential
ameliorative
factor.
Specifically,
there
is
growing
understanding
exercise-induced
improvement
may
be
mediated
by
molecules
known
exerkines.
This
review
delves
into
impact
on
elucidating
mechanisms
through
which
various
exerkines
bolster
function
this
context.
Additionally,
discussion
extends
to
role
facilitating
stem
cell
mobilization,
offering
avenue
for
improving
impairment.
Journal of Medical Internet Research,
Journal Year:
2024,
Volume and Issue:
26, P. e56883 - e56883
Published: March 19, 2024
Background
With
the
rapid
aging
of
global
population,
prevalence
mild
cognitive
impairment
(MCI)
and
dementia
is
anticipated
to
surge
worldwide.
MCI
serves
as
an
intermediary
stage
between
normal
dementia,
necessitating
more
sensitive
effective
screening
tools
for
early
identification
intervention.
The
BrainFx
SCREEN
a
novel
digital
tool
designed
assess
impairment.
This
study
evaluated
its
efficacy
in
primary
care
settings,
particularly
context
population
growing
integration
health
solutions.
Objective
objective
was
validity,
reliability,
applicability
(hereafter,
SCREEN)
context.
We
conducted
exploratory
comparing
with
established
tool,
Quick
Mild
Cognitive
Impairment
(Qmci)
screen.
Methods
A
concurrent
mixed
methods,
prospective
using
quasi-experimental
design
147
participants
from
5
Family
Health
Teams
(FHTs;
characterized
by
multidisciplinary
practice
capitated
funding)
across
southwestern
Ontario,
Canada.
Participants
included
practitioners,
patients,
FHT
administrative
executives.
Individuals
aged
≥55
years
no
history
or
diagnosis
rostered
participating
were
eligible
participate.
screened
both
Qmci.
also
incorporated
Geriatric
Anxiety
Scale–10
general
anxiety
levels
at
each
screening.
SCREEN’s
scoring
compared
against
that
Qmci
clinical
judgment
professionals.
Statistical
analyses
sensitivity,
specificity,
internal
consistency,
test-retest
reliability
assessments.
Results
found
longer
administration
time
complex
algorithm,
which
proprietary
unavailable
independent
analysis,
presented
challenges.
Its
indicated
Cronbach
α
0.63,
below
acceptable
threshold.
showed
limitations,
moderate
intraclass
correlation
coefficient
(0.54)
inadequate
κ
(0.15)
values.
Sensitivity
specificity
consistent
(63.25%
74.07%,
respectively)
cross-tabulation
discrepant
analysis.
In
addition,
faced
limitations
due
demographic
skew
(96/147,
65.3%
female,
well-educated
participants),
absence
comprehensive
gold
standard
diagnosis,
financial
constraints
limiting
inclusion
confirmatory
neuropsychological
testing.
Conclusions
SCREEN,
current
form,
does
not
meet
necessary
criteria
optimal
primarily
lower
reliability.
As
number
technologies
increases
evolves,
further
testing
refinement
such
are
essential
ensure
their
real-world
settings.
advocates
continued
research
this
rapidly
advancing
field
better
serve
population.
International
Registered
Report
Identifier
(IRRID)
RR2-10.2196/25520
Healthcare,
Journal Year:
2024,
Volume and Issue:
12(18), P. 1879 - 1879
Published: Sept. 19, 2024
Objectives:
Controlling
the
lifestyle
associated
with
dementia
risk
can
delay
process
of
cognitive
decline.
Subjective
decline
(SCD)
and
mild
impairment
(MCI)
are
early
states
in
development
also
window
period
for
intervention
dementia.
The
purpose
this
study
was
to
explore
association
between
multi-domain
objective
elderly
people
SCD
MCI
Chinese
communities
provide
reference
effective
implementation
precise
health
management
measures
reduce
Methods:
A
total
265
middle-aged
volunteers
recruited
from
community
were
divided
into
group
(107
cases),
(80
healthy
control
(HC)
(78
cases).
All
participants
received
clinical
interview,
examination,
assessments.
Results:
Dementia
Risk
Reduction
Lifestyle
Scale
(DRRLS)
scores
HC,
SCD,
groups
[110.00
(11.25)
vs.
101.00
(10.00)
79.50
(20.75)]
exhibited
statistically
significant
differences
among
them.
score
DRRLS
showed
a
negative
correlation
Trail-Making
Test
(TMT),
positive
correlations
both
Verbal
Fluency
(VFT)
Auditory
Learning
(AVLT)
(p
<
0.05).
After
adjusting
confounding
factors,
such
as
age
years
education,
multiple
linear
regression
analysis
revealed
several
points.
In
group,
brain-strengthening
exercise
interpersonal
relationship
negatively
correlated
TMT
(β
=
−11.257,
−15.077;
all
p
0.05),
while
responsibility,
smoking
behavior,
positively
AVLT
0.485,
0.344,
0.406;
Group,
exercise,
brain-healthy
diet,
−22.011,
−16.206,
−11.696;
0.01),
whereas
mental
activity,
relationship,
stress
0.450,
0.435,
0.308,
0.256,
0.607;
Conclusions:
communities,
unhealthy
individuals
is
significantly
function
impairment.
greater
their
habits,
more
pronounced
scope
severity
becomes.
Furthermore,
different
dimensions
have
varying
impacts
on
domains.