Association between Multi-Domain Lifestyle and Objective Cognitive Impairment in Elderly People with SCD and MCI in Chinese Communities DOI Open Access

Yuqin Sun,

Ruifen Zhang,

Zhiqun Mao

et al.

Healthcare, Journal Year: 2024, Volume and Issue: 12(18), P. 1879 - 1879

Published: Sept. 19, 2024

Objectives: Controlling the lifestyle associated with dementia risk can delay process of cognitive decline. Subjective decline (SCD) and mild impairment (MCI) are early states in development also window period for intervention dementia. The purpose this study was to explore association between multi-domain objective elderly people SCD MCI Chinese communities provide reference effective implementation precise health management measures reduce Methods: A total 265 middle-aged volunteers recruited from community were divided into group (107 cases), (80 healthy control (HC) (78 cases). All participants received clinical interview, examination, assessments. Results: Dementia Risk Reduction Lifestyle Scale (DRRLS) scores HC, SCD, groups [110.00 (11.25) vs. 101.00 (10.00) 79.50 (20.75)] exhibited statistically significant differences among them. score DRRLS showed a negative correlation Trail-Making Test (TMT), positive correlations both Verbal Fluency (VFT) Auditory Learning (AVLT) (p < 0.05). After adjusting confounding factors, such as age years education, multiple linear regression analysis revealed several points. In group, brain-strengthening exercise interpersonal relationship negatively correlated TMT (β = −11.257, −15.077; all p 0.05), while responsibility, smoking behavior, positively AVLT 0.485, 0.344, 0.406; Group, exercise, brain-healthy diet, −22.011, −16.206, −11.696; 0.01), whereas mental activity, relationship, stress 0.450, 0.435, 0.308, 0.256, 0.607; Conclusions: communities, unhealthy individuals is significantly function impairment. greater their habits, more pronounced scope severity becomes. Furthermore, different dimensions have varying impacts on domains.

Language: Английский

Current status and trends in the study of intestinal flora in cognitive disorders: a bibliometric and visual analysis DOI Creative Commons
Qi Zhang, Zongyan Gao, Yushan Deng

et al.

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: May 27, 2025

Background Cognitive impairment is a decline in people’s ability to think, learn, and remember, which has some impact on an individual’s daily activities or social functioning. Microbial toxins metabolites from dysregulated gut microbiota directly interact with the intestinal epithelium. This interaction triggers neuroinflammation neurodegeneration central nervous system, ultimately impairing cognitive function. It been found that modulation of flora can be effective intervention improve dysfunction. study first summarize outline global research status trends this field bibliometric perspective, providing reference guidance for future field. Methods Based Web Science Core Collection (WoSCC) database, Literature published between 1999–2025 was searched. Bibliometric analysis performed using VOSviewer CiteSpace software analyze data countries, institutions, authors, journals, keywords, citations, generate visual maps. Results A total 1,702 pieces related literature were retrieved. The overall trend publication increasing. China largest number papers, Huazhong University &amp; Technology Kim, Dong-Hyun institutions individuals more publications. most frequently cited journal SCI REP-UK . frequent keywords are microbiota, followed by Alzheimer’s disease, impairment, Brain, oxidative stress Inflammation. Conclusion In recent years, application treatment made remarkable progress. Oxidative inflammatory response have become main hotspots patients. gut-brain axis plays important role mechanism action. Short-chain fatty acids focus microbial metabolism. Fecal transplantation technology increasingly being used as emerging method flora. Modifying modifying diet exercise may strategy prevent dysfunction future. Future studies gender differences

Language: Английский

Citations

0
Cognitive Fitness: Harnessing the Strength of Exerkines for Aging and Metabolic Challenges DOI Creative Commons
Mona Saheli,

Mandana Moshrefi,

Masoumeh Baghalishahi

et al.

Sports, Journal Year: 2024, Volume and Issue: 12(2), P. 57 - 57

Published: Feb. 13, 2024

Addressing cognitive impairment (CI) represents a significant global challenge in health and social care. Evidence suggests that aging metabolic disorders increase the risk of CI, yet promisingly, physical exercise has been identified as potential ameliorative factor. Specifically, there is growing understanding exercise-induced improvement may be mediated by molecules known exerkines. This review delves into impact on elucidating mechanisms through which various exerkines bolster function this context. Additionally, discussion extends to role facilitating stem cell mobilization, offering avenue for improving impairment.

Language: Английский

Citations

2
Psychometric Evaluation of a Tablet-Based Tool to Detect Mild Cognitive Impairment in Older Adults: Mixed Methods Study DOI Creative Commons
Josephine McMurray, AnneMarie Levy,

W. S. Pang

et al.

Journal of Medical Internet Research, Journal Year: 2024, Volume and Issue: 26, P. e56883 - e56883

Published: March 19, 2024

Background With the rapid aging of global population, prevalence mild cognitive impairment (MCI) and dementia is anticipated to surge worldwide. MCI serves as an intermediary stage between normal dementia, necessitating more sensitive effective screening tools for early identification intervention. The BrainFx SCREEN a novel digital tool designed assess impairment. This study evaluated its efficacy in primary care settings, particularly context population growing integration health solutions. Objective objective was validity, reliability, applicability (hereafter, SCREEN) context. We conducted exploratory comparing with established tool, Quick Mild Cognitive Impairment (Qmci) screen. Methods A concurrent mixed methods, prospective using quasi-experimental design 147 participants from 5 Family Health Teams (FHTs; characterized by multidisciplinary practice capitated funding) across southwestern Ontario, Canada. Participants included practitioners, patients, FHT administrative executives. Individuals aged ≥55 years no history or diagnosis rostered participating were eligible participate. screened both Qmci. also incorporated Geriatric Anxiety Scale–10 general anxiety levels at each screening. SCREEN’s scoring compared against that Qmci clinical judgment professionals. Statistical analyses sensitivity, specificity, internal consistency, test-retest reliability assessments. Results found longer administration time complex algorithm, which proprietary unavailable independent analysis, presented challenges. Its indicated Cronbach α 0.63, below acceptable threshold. showed limitations, moderate intraclass correlation coefficient (0.54) inadequate κ (0.15) values. Sensitivity specificity consistent (63.25% 74.07%, respectively) cross-tabulation discrepant analysis. In addition, faced limitations due demographic skew (96/147, 65.3% female, well-educated participants), absence comprehensive gold standard diagnosis, financial constraints limiting inclusion confirmatory neuropsychological testing. Conclusions SCREEN, current form, does not meet necessary criteria optimal primarily lower reliability. As number technologies increases evolves, further testing refinement such are essential ensure their real-world settings. advocates continued research this rapidly advancing field better serve population. International Registered Report Identifier (IRRID) RR2-10.2196/25520

Language: Английский

Citations

2
Association Between Cognitive Function and Risk of Chronic Kidney Disease: A Longitudinal Cohort and Mendelian Randomization Study DOI
Sisi Yang, Chun Zhou, Ziliang Ye

et al.

Mayo Clinic Proceedings, Journal Year: 2024, Volume and Issue: 99(9), P. 1399 - 1410

Published: Aug. 6, 2024

Language: Английский

Citations

2
Association between Multi-Domain Lifestyle and Objective Cognitive Impairment in Elderly People with SCD and MCI in Chinese Communities DOI Open Access

Yuqin Sun,

Ruifen Zhang,

Zhiqun Mao

et al.

Healthcare, Journal Year: 2024, Volume and Issue: 12(18), P. 1879 - 1879

Published: Sept. 19, 2024

Objectives: Controlling the lifestyle associated with dementia risk can delay process of cognitive decline. Subjective decline (SCD) and mild impairment (MCI) are early states in development also window period for intervention dementia. The purpose this study was to explore association between multi-domain objective elderly people SCD MCI Chinese communities provide reference effective implementation precise health management measures reduce Methods: A total 265 middle-aged volunteers recruited from community were divided into group (107 cases), (80 healthy control (HC) (78 cases). All participants received clinical interview, examination, assessments. Results: Dementia Risk Reduction Lifestyle Scale (DRRLS) scores HC, SCD, groups [110.00 (11.25) vs. 101.00 (10.00) 79.50 (20.75)] exhibited statistically significant differences among them. score DRRLS showed a negative correlation Trail-Making Test (TMT), positive correlations both Verbal Fluency (VFT) Auditory Learning (AVLT) (p < 0.05). After adjusting confounding factors, such as age years education, multiple linear regression analysis revealed several points. In group, brain-strengthening exercise interpersonal relationship negatively correlated TMT (β = −11.257, −15.077; all p 0.05), while responsibility, smoking behavior, positively AVLT 0.485, 0.344, 0.406; Group, exercise, brain-healthy diet, −22.011, −16.206, −11.696; 0.01), whereas mental activity, relationship, stress 0.450, 0.435, 0.308, 0.256, 0.607; Conclusions: communities, unhealthy individuals is significantly function impairment. greater their habits, more pronounced scope severity becomes. Furthermore, different dimensions have varying impacts on domains.

Language: Английский

Citations

1