CSF GPNMB in Parkinson's disease: A potential association with age and microglial activation DOI Creative Commons
Xi-Chen Zhu, Yasuaki Mizutani, Reiko Ohdake

et al.

Journal of Parkinson s Disease, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 8, 2024

Recent evidence suggests a link between glycoprotein non-metastatic melanoma protein B (GPNMB) and Parkinson's disease (PD) pathogenesis. Although elevated plasma GPNMB levels associated with severity have been reported in PD, cerebrospinal fluid (CSF) alterations remain elusive. To explore CSF its clinical significance PD. This study enrolled 118 sporadic PD patients 40 controls. We examined the potential associations characteristics or biomarkers of neurodegenerative had higher than controls (p = 0.0159). In group, correlated age (age at examination: rs 0.2511, p 0.0061; onset: 0.2800, 0.0021) motor cognitive dysfunction (MDS-UPDRS III score: 0.1998, 0.0347; Mini-Mental State Examination -0.1922, 0.0370). After correcting for multiple comparisons, correlation onset remained significant. were also positively soluble triggering receptor expressed on myeloid cells 2 (sTREM2) both (rs 0.3582, < 0.0001) control 0.4743, 0.0023) groups. Furthermore, regression analysis revealed sTREM2 level as strongest determinant group (t-value 3.49, 0.0007). Elevated levels, linked microglial activation, may be valuable marker understanding interplay aging, neuroinflammation, pathology.

Language: Английский

Mapping the Research of Ferroptosis in Parkinson’s Disease from 2013 to 2023: A Scientometric Review DOI Creative Commons
Yingfan Chen,

Zhenhui Wu,

Shaodan Li

et al.

Drug Design Development and Therapy, Journal Year: 2024, Volume and Issue: Volume 18, P. 1053 - 1081

Published: April 1, 2024

Methods: Related studies on PD and ferroptosis were searched in Web of Science Core Collection (WOSCC) from inception to 2023. VOSviewer, CiteSpace, RStudio, Scimago Graphica employed as bibliometric analysis tools generate network maps about the collaborations between authors, countries, institutions visualize co-occurrence trends co-cited references keywords. Results: A total 160 original articles reviews related retrieved, produced by 958 authors 162 institutions. Devos David was most prolific author, with 9 articles. China University Melbourne had leading positions publication volume 84 12 publications, respectively. Current hot topics focus excavating potential new targets for treating based gaining insight into specific molecular mechanisms, including iron metabolism disorders, lipid peroxidation, imbalanced antioxidant regulation. Clinical aimed at targeting remain their preliminary stages. Conclusion: continued increase shown literature within field over past decade. The current study suggested active among Research pathogenesis treatment has remained a prominent topic recent years, indicating that ferroptosis-targeted therapy is approach halting progression PD. Keywords: Parkinson's disease, ferroptosis, analysis, accumulation, alpha-synuclein, mitochondrial dysfunction, oxidative stress, peroxidation

Language: Английский

Citations

7
Do oral antidiabetic medications alter the risk of Parkinson’s disease? An updated systematic review and meta-analysis DOI

Yanna Xie,

Jialiang Wang, Jie Jiang

et al.

Neurological Sciences, Journal Year: 2023, Volume and Issue: 44(12), P. 4193 - 4203

Published: July 27, 2023

Language: Английский

Citations

9
CSF GPNMB in Parkinson's disease: A potential association with age and microglial activation DOI Creative Commons
Xi-Chen Zhu, Yasuaki Mizutani, Reiko Ohdake

et al.

Journal of Parkinson s Disease, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 8, 2024

Recent evidence suggests a link between glycoprotein non-metastatic melanoma protein B (GPNMB) and Parkinson's disease (PD) pathogenesis. Although elevated plasma GPNMB levels associated with severity have been reported in PD, cerebrospinal fluid (CSF) alterations remain elusive. To explore CSF its clinical significance PD. This study enrolled 118 sporadic PD patients 40 controls. We examined the potential associations characteristics or biomarkers of neurodegenerative had higher than controls (p = 0.0159). In group, correlated age (age at examination: rs 0.2511, p 0.0061; onset: 0.2800, 0.0021) motor cognitive dysfunction (MDS-UPDRS III score: 0.1998, 0.0347; Mini-Mental State Examination -0.1922, 0.0370). After correcting for multiple comparisons, correlation onset remained significant. were also positively soluble triggering receptor expressed on myeloid cells 2 (sTREM2) both (rs 0.3582, < 0.0001) control 0.4743, 0.0023) groups. Furthermore, regression analysis revealed sTREM2 level as strongest determinant group (t-value 3.49, 0.0007). Elevated levels, linked microglial activation, may be valuable marker understanding interplay aging, neuroinflammation, pathology.

Language: Английский

Citations

0