Progress of Chinese Medicine in Regulating Microglial Polarization against Alzheimer’s Disease DOI

Fengge Yang,

Wei Gao,

J Z Wang

et al.

The American Journal of Chinese Medicine, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 21

Published: Dec. 24, 2024

Alzheimer’s disease (AD), the predominant form of dementia, is a neurodegenerative disorder central nervous system (CNS) characterized by subtle onset and spectrum cognitive functional declines. The clinical manifestation AD encompasses memory deficits, deterioration, behavioral disturbances, culminating in severe impairment daily living skills. Despite its high prevalence, accounting for 60–70% all dementia cases, there remains an absence curative therapeutics. Microglia (MG), resident immune cells CNS, exhibit bifurcated role pathogenesis. Functioning neuroprotective capacity, MGs express scavenger receptors, facilitating clearance [Formula: see text]-amyloid protein (A[Formula: text]) cellular debris. Conversely, aberrant activation can lead to secretion pro-inflammatory cytokines, thereby propagating neuroinflammatory responses that are detrimental neuronal integrity. dynamics MG ensuing neuroinflammation pivotal evolution AD. Chinese medicine (CM), treasure trove traditional cultural practices, has demonstrated significant potential therapeutic management Over past triennium, CM garnered considerable research attention multifaceted approaches AD, including regulation polarization. This review synthesizes current knowledge on origins, polarization dynamics, mechanistic interplay with pathology. It further explores nexus between cardinal pathological hallmarks such as A[Formula: text] plaque deposition, hyperphosphorylation tau, synaptic plasticity impairments, neuroinflammation, brain–gut-axis dysregulation. also encapsulates strategies CM, which encompass monomers, formulae, acupuncture. These modulate context treatment, providing robust theoretical framework conduct future investigative endeavors both preclinical realms.

Language: Английский

Current Status of Plant-Based Bioactive Compounds as Therapeutics in Alzheimer’s Diseases DOI Creative Commons
Dan Chen,

Yun Sun

Journal of Integrative Neuroscience, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 20, 2025

Alzheimer’s disease (AD) is a common central neurodegenerative disorder characterized primarily by cognitive impairment and non-cognitive neuropsychiatric symptoms that significantly impact patients’ daily lives behavioral functioning. The pathogenesis of AD remains unclear current Western medicines treatment are purely symptomatic, with singular pathway, limited efficacy, substantial toxicity side effects. In recent years, as research into has deepened, there been gradual increase in the exploration application medicinal plants for AD. Numerous studies have shown their active ingredients can potentially mitigate regulating various molecular mechanisms, including production aggregation pathological proteins, oxidative stress, neuroinflammation, apoptosis, mitochondrial dysfunction, neurogenesis, neurotransmission, brain-gut microbiota axis. this review, we analyzed comprehensively summarized advancements on AD, along underlying mechanisms clinical evidence. Ultimately, aimed to provide reference further investigation specific through which prevent treat well identification efficacious derived from plants.

Language: Английский

Citations

0
Progress of Chinese Medicine in Regulating Microglial Polarization against Alzheimer’s Disease DOI

Fengge Yang,

Wei Gao,

J Z Wang

et al.

The American Journal of Chinese Medicine, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 21

Published: Dec. 24, 2024

Alzheimer’s disease (AD), the predominant form of dementia, is a neurodegenerative disorder central nervous system (CNS) characterized by subtle onset and spectrum cognitive functional declines. The clinical manifestation AD encompasses memory deficits, deterioration, behavioral disturbances, culminating in severe impairment daily living skills. Despite its high prevalence, accounting for 60–70% all dementia cases, there remains an absence curative therapeutics. Microglia (MG), resident immune cells CNS, exhibit bifurcated role pathogenesis. Functioning neuroprotective capacity, MGs express scavenger receptors, facilitating clearance [Formula: see text]-amyloid protein (A[Formula: text]) cellular debris. Conversely, aberrant activation can lead to secretion pro-inflammatory cytokines, thereby propagating neuroinflammatory responses that are detrimental neuronal integrity. dynamics MG ensuing neuroinflammation pivotal evolution AD. Chinese medicine (CM), treasure trove traditional cultural practices, has demonstrated significant potential therapeutic management Over past triennium, CM garnered considerable research attention multifaceted approaches AD, including regulation polarization. This review synthesizes current knowledge on origins, polarization dynamics, mechanistic interplay with pathology. It further explores nexus between cardinal pathological hallmarks such as A[Formula: text] plaque deposition, hyperphosphorylation tau, synaptic plasticity impairments, neuroinflammation, brain–gut-axis dysregulation. also encapsulates strategies CM, which encompass monomers, formulae, acupuncture. These modulate context treatment, providing robust theoretical framework conduct future investigative endeavors both preclinical realms.

Language: Английский

Citations

0