High Levels of C5a Are Associated With Reduced Macular Sensitivity in Patients With Myeloproliferative Neoplasms

Investigative Ophthalmology & Visual Science, Journal Year: 2025, Volume and Issue: 66(2), P. 41 - 41

Published: Feb. 13, 2025

Purpose: Previous findings indicate that patients with myeloproliferative neoplasms (MPN) exhibit elevated levels of inflammatory biomarkers and have a high prevalence AMD. In this study, we aim to determine whether drusen systemic inflammation in MPN affect macular sensitivity the same manner as Methods: The study was conducted prospective cross-sectional study. A total 139 eyes 71 were included We measured using microperimetry extracted blood samples evaluate markers. Results: Multilevel linear mixed-effect analysis did not show any difference when comparing AMD those without (β = −0.254, P 0.657). However, higher complement system fragment C5a significantly correlated decreased −0.561, 0.027), irrespective presence drusen. Conclusions: found marker are associated reduced sensitivity, regardless visible degenerative changes area. These suggest an early contribution sensitivity.

Language: Английский

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A cross-sectional observational study of the association between biochemistry profiles and the risk of age-related macular degeneration

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 12, 2025

This study aimed to explore the relationship between biochemical profiles and risk of age-related macular degeneration (AMD) through a cross-sectional observational analysis. We examined data U. S. population from 2005–2008 National Health Nutrition Examination Survey (NHANES) database. Student's t-test, multivariable logistic regression, Pearson's correlation, restricted cubic spline (RCS) model, linear regression were applied analyze underlying AMD risk, comparing non-AMD subgroups. Multivariable adjusted for age demographic factors, showed no significant associations levets specific parameters (P > 0.05). correlation revealed positive total bilirubin, uric acid in subgroup < 0.05), but such liner association was found The RCS model confirmed non-linear relationships presented these variables subgroup. In addition, without adjustment, acid, presence Biochemical profiles, after adjusting age, did not significantly influence risk. However, bilirubin might potentially be related presence. Our findings suggest need further research clarify role biomarkers development.

Language: Английский

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Identifying blood mitochondrial DNA copy number as a biomarker for development of neurodegenerative diseases: Evidence from Mendelian randomization analysis

Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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Red blood cell distribution width-to-albumin ratio and its association with age-related macular degeneration: a population-based cross-sectional study

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: April 15, 2025

Background Age-related macular degeneration (AMD) is a leading cause of central vision impairment in middle-aged and older individuals. There substantial evidence that AMD associated with inflammation. The study aimed to investigate the association between inflammatory marker, red blood cell distribution width/albumin ratio (RAR), AMD. Methods Our included 5,370 participants aged 40 years older, using NHANES data from 2005 2008. Multivariable logistic regression analysis was conducted examine relationship RAR study. Smooth curves piecewise linear model were used determine whether correlation or non-linear. Additionally, subgroup interaction testing performed. Results We found positive AMD, even after adjusting for covariates. Each unit increase corresponded 30% odds prevalence (OR = 1.3; 95% CI, 1.0–1.6). 1.7 times greater highest quintile (Q5) group than lowest (Q1) 1.7; 1.2–2.5). Higher values, compared lower significantly increased ( p trend &lt; 0.05). Subgroup analyses tests confirmed stability findings. Conclusion This there United States adults. Further research necessary clarify specific physiological mechanisms underlying

Language: Английский

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Senescence-related genes and proteins in the development of Alzheimer’s disease: evidence from transcriptomic and Mendelian randomization analysis

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: Aug. 2, 2024

Alzheimer's disease (AD) is a common neurodegenerative disease, which can lead to cognitive impairment and dementia. Since AD tightly associated with aging cellular senescence, objective of this study was investigate the association between senescence-related genes proteins (SRGs SRPs) development AD.

Language: Английский

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