Unveiling the geroprotective potential of Monarda didyma L.: insights from in vitro studies and a randomized clinical trial on slowing biological aging and improving quality of life

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Abstract Aging is driven by fundamental mechanisms like oxidative stress, telomere shortening and changes in DNA methylation, which together prepare the ground for age-related diseases. Botanical extracts, rich bioactive phytoconstituents, represent a promising resource developing therapies that target these to promote healthy aging. This study explores geroprotective potential of Monarda didyma L. extract. In vitro analyses revealed extract’s strong antioxidant activity, ability reduce shortening, capacity protect against damage, thereby decreasing cellular senescence improving endothelial function. The randomized, double-blind clinical trial demonstrated daily oral supplementation with extract significantly improved leukocyte length (LTL) stabilized methylation age (DNAmAge) intervention group, while placebo group experienced accelerated epigenetic aging hypermethylation critical genes (ELOVL2 FHL2). also reported enhanced quality life, particularly physical domain, along movement sleep indices detected questionnaire wearable sensors. These compelling findings position as powerful candidate future therapies, impact

Language: Английский

Exploring the Relationship between Telomere Length and Cognitive Changes in Post-COVID-19 Subjects

Biomedicines, Journal Year: 2024, Volume and Issue: 12(10), P. 2296 - 2296

Published: Oct. 10, 2024

Background/Objectives: Emerging evidence suggests that patients suffering from COVID-19 may experience neurocognitive symptoms. Furthermore, other studies indicate a probable association between leukocyte telomere length (LTL) and changes in subjects with post-COVID-19 condition. Our study was designed to determine the correlation cognitive subjects. Methods: This included 256 subjects, categorized based on SARS-CoV-2 infection 2020 2023. In addition, psychiatric diagnosis were considered. Moreover, MoCA MMSE scales applied. Telomere determined using polymerase chain reaction, statistical analysis employed ANOVA X2 tests. Results: We identified decrease LTL individuals conditions compared those without (p ≤ 0.05). However, no found impairment post-COVID-19. Conclusions: The findings suggest is affected by infection. Nonetheless, this important finding requires further research monitoring neurological post-COVID

Language: Английский