Imaging synaptic density in ageing and Alzheimer's Disease with [18F]-SynVesT-1 DOI Creative Commons
Joseph Giorgio, David N. Soleimani‐Meigooni, Mustafa Janabi

et al.

Published: Oct. 26, 2024

Abstract Monitoring synaptic injury in neurodegenerative diseases may provide new insights into the evolution of degenerative process as well a potential mechanism to target for preservation function. Synaptic density imaging with PET is relatively approach this issue. However, there are remaining questions about technical approaches data analysis including reference region selection, and how specific phenotypic presentations symptoms Alzheimer’s Disease (AD) reflected alterations density. Methods Using an SV2A ligand radiolabeled 18 F isotope ([ F]-SynVesT-1) we performed sensitivity analyses determine optimal tissue modelling derive whole brain ratio images. these images from sample young adults, older patients varied AD then contrast regional vivo biomarkers. Result Reference optimisation concluded that cerebellar grey matter best deriving images, find strong inverse association between [ F]-SynVesT-1 uptake amyloid beta tau deposition. Finally, individuals lower temporal volume but higher show preserved performance on MMSE. Conclusions shows close pathology be possible marker resilience neurodegeneration.

Language: Английский

Imaging Synaptic Density in Aging and Alzheimer Disease with [18F]SynVesT-1 DOI Creative Commons
Joseph Giorgio, David N. Soleimani‐Meigooni, Mustafa Janabi

et al.

Journal of Nuclear Medicine, Journal Year: 2025, Volume and Issue: unknown, P. jnumed.124.269005 - jnumed.124.269005

Published: March 6, 2025

Synaptic density imaging with PET is a relatively new approach to monitoring synaptic injury in neurodegenerative diseases. However, there are remaining technical and clinical questions, including questions on reference region selection how specific phenotypic presentations symptoms of Alzheimer disease (AD) reflected alterations density. Methods: Using vesicle glycoprotein 2A (SV2A) ligand radiolabeled the 18F isotope ([18F]SynVesT-1), we performed sensitivity analyses determine optimal tissue modeling derive whole-brain ratio images. these images from sample young adults, older patients varied AD, then contrasted regional SV2A vivo AD biomarkers. Results: Reference optimization concluded that cerebellar gray matter best for deriving images, found strong inverse association between [18F]SynVesT-1 uptake amyloid β tau deposition. Finally, individuals lower temporal volume but higher show preserved performance mini-mental state examination. Conclusion: shows close pathology, may be possible marker resilience neurodegeneration.

Language: Английский

Citations

0
Comprehensive mapping of synaptic vesicle protein 2A (SV2A) in health and neurodegenerative diseases: a comparative analysis with synaptophysin and ground truth for PET-imaging interpretation DOI

Mahsa Shanaki Bavarsad,

Salvatore Spina,

Abby Oehler

et al.

Acta Neuropathologica, Journal Year: 2024, Volume and Issue: 148(1)

Published: Oct. 30, 2024

Language: Английский

Citations

2
SV2A is expressed in synapse subpopulations in mouse and human brain: implications for PET radiotracer studies DOI
Theresa Wong, Zhen Qiu,

Beverly Notman

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 18, 2024

Abstract Synapse pathology is a feature of most brain diseases and there pressing need to monitor the onset progression this using imaging in living patients. A major step toward goal has been development small-molecule radiotracers that bind synaptic vesicle glycoprotein 2A (SV2A) for use positron emission tomography (PET). Changes SV2A radiotracer binding PET are widely interpreted report differences density all synapses throughout regions. Here, we analyse expression at single-synapse resolution across regions adult mouse human brain. We find expressed fewer than 50% excitatory inhibitory SV2A-positive differs between Furthermore, individual differ their amounts SV2A. These findings have important implications interpretation studies clinical setting point detailed understanding synaptome architecture both healthy disease cases where being applied.

Language: Английский

Citations

0
Imaging synaptic density in ageing and Alzheimer's Disease with [18F]-SynVesT-1 DOI Creative Commons
Joseph Giorgio, David N. Soleimani‐Meigooni, Mustafa Janabi

et al.

Published: Oct. 26, 2024

Abstract Monitoring synaptic injury in neurodegenerative diseases may provide new insights into the evolution of degenerative process as well a potential mechanism to target for preservation function. Synaptic density imaging with PET is relatively approach this issue. However, there are remaining questions about technical approaches data analysis including reference region selection, and how specific phenotypic presentations symptoms Alzheimer’s Disease (AD) reflected alterations density. Methods Using an SV2A ligand radiolabeled 18 F isotope ([ F]-SynVesT-1) we performed sensitivity analyses determine optimal tissue modelling derive whole brain ratio images. these images from sample young adults, older patients varied AD then contrast regional vivo biomarkers. Result Reference optimisation concluded that cerebellar grey matter best deriving images, find strong inverse association between [ F]-SynVesT-1 uptake amyloid beta tau deposition. Finally, individuals lower temporal volume but higher show preserved performance on MMSE. Conclusions shows close pathology be possible marker resilience neurodegeneration.

Language: Английский

Citations

0