Effect of electroacupuncture on the incidence of acute stroke after embolisation of intracranial aneurysm: study protocol for a single-centre, double-blinded, randomised controlled trial
BMJ Open,
Journal Year:
2025,
Volume and Issue:
15(3), P. e090502 - e090502
Published: March 1, 2025
Background
Electroacupuncture
(EA)
is
commonly
used
in
clinical
settings
as
a
significant
method
for
treating
variety
of
pain
and
cerebrovascular
disorders.
Despite
its
widespread
use,
there
limited
information
on
the
impact
perioperative
EA
postoperative
stroke.
This
study
aimed
to
investigate
whether
preoperative
therapy
could
reduce
occurrence
acute
stroke
patients
undergoing
interventional
surgery
intracranial
aneurysms.
Methods/design
single-centre,
double-blind,
placebo-controlled,
randomised
trial
aims
recruit
280
embolisation
aneurysms
under
general
anaesthesia.
Participants
will
be
randomly
assigned
either
group
or
sham
electroacupuncture
(SEA)
group.
The
receive
treatment
half
an
hour
before
surgery,
while
SEA
acupuncture.
primary
outcome
within
7
days
post
surgery.
Secondary
outcomes
include
incidence
symptomatic
occult
same
timeframe,
cerebral
vasospasm
during
operation
number
intraoperative
dissections.
Ethics
dissemination
has
been
approved
by
Committee
First
Affiliated
Hospital
Nanjing
Medical
University
(2023-SR-538.A1).
started
17
May
2024,
it
expected
end
31
March
2025.
results
our
published
peer-reviewed
journals.
Trial
registration
ChiCTR2300076960.
Language: Английский
Mitophagy in perioperative neurocognitive disorder: mechanisms and therapeutic strategies
European journal of medical research,
Journal Year:
2025,
Volume and Issue:
30(1)
Published: April 11, 2025
Perioperative
neurocognitive
disorder
(PND)
is
a
common
neurological
complication
after
surgery/anesthesia
in
elderly
patients
that
affect
postoperative
outcome
and
long-term
quality
of
life,
which
increases
the
cost
family
social
resources.
The
pathological
mechanism
PND
complex
not
fully
understood,
methods
prevention
treatment
are
very
limited,
so
it
particularly
important
to
analyze
PND.
Research
indicates
mitochondrial
dysfunction
pivotal
initiation
progression
PND,
although
precise
mechanisms
remain
elusive
could
involve
disrupted
mitophagy.
We
reviewed
recent
studies
on
link
between
mitophagy
highlighting
role
key
proteins
abnormal
discussing
therapeutic
strategies
aimed
at
regulation.
This
provides
insights
into
underlying
potential
targets.
Language: Английский
Postoperative Electroacupuncture Boosts Cognitive Function Recovery after Laparotomy in Mice
Biomolecules,
Journal Year:
2024,
Volume and Issue:
14(10), P. 1274 - 1274
Published: Oct. 10, 2024
Postoperative
cognitive
dysfunction
(POCD)
is
a
common
complication
that
affects
memory,
executive
function,
and
processing
speed
postoperatively.
The
pathogenesis
of
POCD
linked
to
excessive
neuroinflammation
pre-existing
Alzheimer's
disease
(AD)
pathology.
Previous
studies
have
shown
acupuncture
improves
cognition
in
the
early
phase
POCD.
However,
can
last
for
longer
periods
(up
weeks
years).
long-term
effects
are
unknown.
In
this
study,
we
hypothesized
electroacupuncture
(EA)
could
reduce
inflammation
induced
by
laparotomy
over
period.
We
characterized
postoperative
EA
on
changes
investigated
underlying
molecular
mechanisms
mice.
Laparotomy
was
performed
3-month-old
mice
followed
daily
treatment
2
weeks.
Our
data
indicated
prolonged
impairment
memory
functions,
which
were
mitigated
EA.
also
reduced
tau
phosphorylation
suppressed
activation
tau-related
kinases
glia,
with
comparable
ibuprofen.
These
findings
demonstrate
beneficial
mouse
model
POCD,
suggesting
EA's
ability
suppress
may
contribute
its
protective
effects.
conclusion,
be
viable
non-pharmacological
intervention
managing
different
phases
medical
condition.
Language: Английский
IL‐12p70 Induces Neuroprotection via the PI3K‐AKT‐BCL2 Axis to Mediate the Therapeutic Effect of Electroacupuncture on Postoperative Cognitive Dysfunction
Advanced Biology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 30, 2024
Abstract
Postoperative
cognitive
dysfunction
(POCD),
a
postsurgical
decline
in
function,
primarily
affects
older
adults
and
worsens
their
prognosis.
Although
elevated
interleukin‐12p70
(IL‐12p70)
is
closely
correlated
with
slower
adults,
its
role
POCD
remains
unclear.
Here,
IL‐12p70
identified
as
significant
mediator
of
therapeutic
effect
electroacupuncture
(EA)
on
POCD.
EA
at
acupoints
ST36,
GV20,
GV24
significantly
enhanced
behaviors
mice.
IL‐12p70,
downregulated
mice
but
rescued
by
treatment,
the
cytokine
associated
EA's
effect.
Clinically,
adults’
serum
post‐surgery.
Furthermore,
exerts
potent
neuroprotective
both
neuronal
cell
lines
primary
hippocampal
neurons.
The
PI3K‐AKT‐BCL2
axis
enriched
silico
analysis
validated
signaling
mechanism
underlying
IL‐12p70‐induced
neuroprotection.
In
vivo,
beneficial
effects
treatment
activation
are
reproduced
administration
attenuated
knockdown.
findings
reveal
novel
POCD,
demonstrating
that
activating
newly‐discovered
function
highlight
potential
treating
disorders.
Language: Английский
Current Progress on Postoperative Cognitive Dysfunction: An Update
Journal of Integrative Neuroscience,
Journal Year:
2024,
Volume and Issue:
23(12)
Published: Dec. 24, 2024
Postoperative
cognitive
dysfunction
(POCD)
represents
a
significant
clinical
concern,
particularly
among
elderly
surgical
patients.
It
is
characterized
by
decline
in
performance,
affecting
memory,
attention,
coordination,
orientation,
verbal
fluency,
and
executive
function.
This
abilities
leads
to
longer
hospital
stays
increased
mortality.
review
provides
comprehensive
overview
of
the
current
progress
understanding
relevant
pathogenic
factors,
possible
mechanisms,
diagnosing,
prevention
treatment
POCD,
as
well
suggesting
future
research
directions.
discusses
neuronal
damage,
susceptible
genes,
central
cholinergic
system,
nervous
system
(CNS)
inflammation,
stress
response
glucocorticoids,
oxidative
development
aiming
uncover
pathological
mechanism
develop
effective
strategies
for
POCD.
Language: Английский