Having Sexual Partners Lowers the Risk of Glaucoma-A Mendelian Randomization Study DOI

hua Zhuang,

Wu-Zhen Zhang

Published: Oct. 11, 2024

Abstract Objectives: Previous paper suggested that engaging in sexual activity exacerbated glaucoma symptoms. However, we challenge this viewpoint and designed Mendelian randomization(MR) study to uncover the truth. Methods: To investigate causal relationship between two, experiment utilized single nucleotide polymorphism(SNPs) related "lifetime number of partners" (LNSP) from United Kingdom Biobank (UKB) SNPs associated with FinnGen Database. There were a total 63 highly correlated LNSP at genome-wide significant level, which merged glaucoma-related SNPs. After removing their palindromic sequences, MR was conducted using TwoSample-MR R package. Additionally, tests for heterogeneity pleiotropy performed programming. Results: In group, analysis showed: inverse variance weighted(IVW)(OR=0.758, P=0.030), Egger(OR=0.654,P=0.475), simple mode (OR=0.854,P=0.657), weighted median (OR=0.819, P=0.221) mode(OR=0.803,P=0.501). primary open angle (POAG) result IVW(OR=0.897,P=0.570), Egger(OR=0.425, P=0.335), mode(OR=1.659, P=0.412), median(OR=1.052, P=0.855) mode(OR=1.464,P=0.533). Heterogeneity not detected either group. The funnel plots both groups relatively symmetrical. Conclusion: We reveal truth having partners only does increase overall incidence but, conversely, also lowers its incidence. Therefore, patients should pursue fulfilling life your peace mind.

Language: Английский

Exploring the effect of SGLT2 inhibitors on the risk of primary open-angle glaucoma using Mendelian randomization analysis DOI Creative Commons

Yujin Guo,

Wei Zhao, Shuai Hou

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 22, 2025

This study aimed to evaluate the causal effect of sodium-glucose cotransporter protein 2 (SGLT2) inhibition on primary open-angle glaucoma (POAG) and explore potential mechanisms. A drug-targeted Mendelian randomization (MR) was conducted using genetic variation related SGLT2 inhibition, based gene expression glycated hemoglobin levels. Genetic summary statistics for POAG were obtained from FinnGen consortium a multi-ancestry genome-wide association study. Glaucomatous endophenotype data also incorporated. two-step MR analysis performed examine whether pathways obesity, blood pressure, lipid levels, oxidative stress, inflammation mediated between POAG. Genetically predicted associated with reduced risk (OR: 0.28; 95% CI: 0.12 0.63; P = 2.22 × 10- 3), confirmed in validation cohort. It decreased optic cup area, vertical cup-disc ratio, increased disc area. Mediation indicated that partly by diastolic pressure (4.8%). suggests is promising therapeutic target However, further large-scale randomized controlled trials are required confirm these findings.

Language: Английский

Citations

0
Sodium-glucose cotransporter protein 2 inhibition, plasma proteins, and ischemic stroke: A mediation Mendelian randomization and colocalization study DOI Creative Commons
Zhiqing Chen, Hongmei Meng,

Yujin Guo

et al.

Journal of Stroke and Cerebrovascular Diseases, Journal Year: 2024, Volume and Issue: 34(1), P. 108136 - 108136

Published: Nov. 12, 2024

To determine the effect of sodium-glucose cotransporter protein 2 (SGLT2) inhibition on ischemic stroke (IS) and investigate circulating proteins that mediate effects SGLT2 IS.

Language: Английский

Citations

1
The Role of Interleukin-24 and Downstream Pathways in Inflammatory and Autoimmune Diseases DOI

Qiyun An,

Xiaoyu Gu, Yuying Jiang

et al.

Cell Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 7, 2024

Language: Английский

Citations

0
Having Sexual Partners Lowers the Risk of Glaucoma-A Mendelian Randomization Study DOI

hua Zhuang,

Wu-Zhen Zhang

Published: Oct. 11, 2024

Abstract Objectives: Previous paper suggested that engaging in sexual activity exacerbated glaucoma symptoms. However, we challenge this viewpoint and designed Mendelian randomization(MR) study to uncover the truth. Methods: To investigate causal relationship between two, experiment utilized single nucleotide polymorphism(SNPs) related "lifetime number of partners" (LNSP) from United Kingdom Biobank (UKB) SNPs associated with FinnGen Database. There were a total 63 highly correlated LNSP at genome-wide significant level, which merged glaucoma-related SNPs. After removing their palindromic sequences, MR was conducted using TwoSample-MR R package. Additionally, tests for heterogeneity pleiotropy performed programming. Results: In group, analysis showed: inverse variance weighted(IVW)(OR=0.758, P=0.030), Egger(OR=0.654,P=0.475), simple mode (OR=0.854,P=0.657), weighted median (OR=0.819, P=0.221) mode(OR=0.803,P=0.501). primary open angle (POAG) result IVW(OR=0.897,P=0.570), Egger(OR=0.425, P=0.335), mode(OR=1.659, P=0.412), median(OR=1.052, P=0.855) mode(OR=1.464,P=0.533). Heterogeneity not detected either group. The funnel plots both groups relatively symmetrical. Conclusion: We reveal truth having partners only does increase overall incidence but, conversely, also lowers its incidence. Therefore, patients should pursue fulfilling life your peace mind.

Language: Английский

Citations

0