Medial Temporal Lobe Subfields Correlate with Alzheimer's Cognitive Domains; Insights from High-Resolution T2 MRI of ADNI Database DOI Creative Commons
Parsa Saberian, Mehrdad Mozafar, Mohammad Sadeghi

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 15, 2024

Abstract Background Alzheimer's Disease (AD) causes multi-domain cognitive decline. Brain imaging biomarkers and neuropsychiatric testing detect difficulties, although it is unclear how processes medial temporal lobe subregions relate. High-resolution T2 MRIs of AD patients' lobes were compared to composite scores for memory, language, executive function, visuospatial ability. Methods 156 Neuroimaging Initiative (ADNI) participants provided data. Composite high-resolution MRI volumetric assessments obtained. Multiple linear regression was used account factors analyze regional volumes. Results In patients, left cornu ammonis (CA), subiculum (SUB), perirhinal cortices (BA35), bilateral parahippocampal cortex (PHC) size positively linked with memory performance. Language strongly connected hippocampi cortical volumes in moderate impairment, right entorhinal (ERC) volume patients. The SUB normal function the Cognitively people had better visual-spatial skills. Conclusion Across stages, composites unique structure-function patterns, hemisphere effects preceding participation, underlining their combined value early disease identification monitoring.

Language: Английский

Identification of critical genes and drug repurposing targets in entorhinal cortex of Alzheimer’s disease DOI
Arghavan Hosseinpouri, Khadijeh Sadegh, Zeinab Zarei‐Behjani

et al.

Neurogenetics, Journal Year: 2025, Volume and Issue: 26(1)

Published: Feb. 10, 2025

Language: Английский

Citations

0
Regional susceptibility of PV interneurons in an hAPP-KI mouse model of Alzheimer’s disease pathology DOI Creative Commons
Mercedes M. Gonzalez, Benjamin Magondu, Matthew JM Rowan

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

Early-stage Alzheimer's pathology correlates with disrupted neuronal excitability, which can drive network and cognitive dysfunction even prior to neurodegeneration. However, the emergence extent of these changes may vary by brain region cell types situated in those regions. Here we aimed investigate effects AD on different neuron subtypes both entorhinal cortex, a enhanced early AD, primary visual relatively unaffected early-stage AD. We designed employed semi-automated patch clamp electrophysiology apparatus record from fast-spiking parvalbumin interneurons excitatory neurons regions, recording over 150 cells young adult APP-KI mice. In amyloid overproduction resulted PV interneuron hypoexcitability, whereas were concurrently hyperexcitable. Conversely, either subclass largely cortex. Together, findings suggest that but not play an integral role progression.

Language: Английский

Citations

0
Cerebrospinal Fluid CCL25 as a Biomarker for Alzheimer's Disease: Associations with Pathology, Neurodegeneration, and Cognitive Decline DOI
Yuhan Chen, Zhibo Wang,

Xipeng Liu

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: May 14, 2025

Language: Английский

Citations

0
Navigating space and the developing mind DOI Creative Commons

Adrienn Réka Németh,

Sandra Stojić, Zoltán Nádasdy

et al.

Frontiers in Psychology, Journal Year: 2025, Volume and Issue: 16

Published: May 14, 2025

In this article, we review the extensive and complex fabric of literature concerning ontogenesis spatial representations from earliest childhood to elderly, including normal abnormal aging (dementia Alzheimer’s disease). We also revisit fundamental concepts neuronal space, egocentric vs. allocentric reference frames, path integration. highlight a thread contradictions in cognition infant first breakthrough at around age four. The reemerge on age-related decline cognition. argue that these derive incorrect assumption integration is exclusively associated with frames references, hence, signatures are often taken as evidence for perspective-taking. posit several can be resolved by acknowledging agnostic type frame implemented both reference. By freeing integration, arrive developmental trajectory consistent across cognitive development studies, enabling us ask questions may dissolve obscurity topic. new model sheds light very early stage

Language: Английский

Citations

0
The Effect of the Optogenetic Stimulation of Astrocytes on Neural Network Activity in an In Vitro Model of Alzheimer’s Disease DOI Open Access
Еlena V. Mitroshina,

Elizaveta P. Kalinina,

Alena Kalyakulina

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12237 - 12237

Published: Nov. 14, 2024

Optogenetics is a combination of optical and genetic technologies used to activate or, conversely, inhibit specific cells in living tissues. The possibilities using optogenetics approaches for the treatment epilepsy, Parkinson’s Alzheimer’s disease (AD) are being actively researched. In recent years, it has become clear that one most important players development AD astrocytes. Astrocytes affect amyloid clearance, participate neuroinflammation, regulate functioning neural networks. We an adeno-associated virus carrying glial fibrillary acidic protein (GFAP) promoter driving optogenetic channelrhodopsin-2 (ChR2) gene transduce astrocytes primary mouse hippocampal cultures. recorded bioelectrical activity networks from day 14 21 cultivation multielectrode arrays. A single stimulation at (DIV14) did not cause significant changes network activity. Chronic DIV14 DIV21 exerts stimulatory effect on cultures (the proportion spikes included bursts significantly increased since DIV19). Moreover, chronic over seven days partially preserved functional architecture neuronal amyloidosis modeling. These results suggest selective activation may represent promising novel therapeutic strategy combating AD.

Language: Английский

Citations

1
Medial Temporal Lobe Subfields Correlate with Alzheimer's Cognitive Domains; Insights from High-Resolution T2 MRI of ADNI Database DOI Creative Commons
Parsa Saberian, Mehrdad Mozafar, Mohammad Sadeghi

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 15, 2024

Abstract Background Alzheimer's Disease (AD) causes multi-domain cognitive decline. Brain imaging biomarkers and neuropsychiatric testing detect difficulties, although it is unclear how processes medial temporal lobe subregions relate. High-resolution T2 MRIs of AD patients' lobes were compared to composite scores for memory, language, executive function, visuospatial ability. Methods 156 Neuroimaging Initiative (ADNI) participants provided data. Composite high-resolution MRI volumetric assessments obtained. Multiple linear regression was used account factors analyze regional volumes. Results In patients, left cornu ammonis (CA), subiculum (SUB), perirhinal cortices (BA35), bilateral parahippocampal cortex (PHC) size positively linked with memory performance. Language strongly connected hippocampi cortical volumes in moderate impairment, right entorhinal (ERC) volume patients. The SUB normal function the Cognitively people had better visual-spatial skills. Conclusion Across stages, composites unique structure-function patterns, hemisphere effects preceding participation, underlining their combined value early disease identification monitoring.

Language: Английский

Citations

0