Brain Volume Loss After Stereotactic Laser Interstitial Thermal Therapy in Patients With Temporal Lobe Epilepsy DOI Creative Commons
Sebastian Johannes Müller, Eya Khadhraoui,

O. Kukhlenko

et al.

Journal of Neuroimaging, Journal Year: 2025, Volume and Issue: 35(2)

Published: March 1, 2025

ABSTRACT Background and Purpose Temporal lobe epilepsy is the most common form of focal epilepsy. MR‐guided laser interstitial thermal therapy (LITT) amygdalohippocampal complex has become an established option in case drug resistance. Long‐term anatomic network effects on brain due to deafferentiation have not yet been evaluated. Methods We analyzed volumes 11 patients with temporal before 1‐year after hippocampal LITT FastSurfer segmenting T1‐weighted data. Additionally, we performed visual ratings measurements. Results A total (7 left‐sided, 4 right‐sided) were included (5 females); mean age years (±standard deviation) at surgery was 41.5 (±18.4) years. The postoperative defect size 1427 (±517) mm 3 . Volumetry as well found a progressive volume loss left‐sided ipsilateral lobe, contralateral (right) part thalamus, especially fusiform cortex. These changes could be detected for right‐sided surgery. Conclusion (partial) ablation left (dominant) hippocampus appears exert long‐term right thalamus cortices. However, observe this effect reverse direction. Volumetric studies larger cohorts should conducted investigate these findings.

Language: Английский

Brain Volume Loss After Stereotactic Laser Interstitial Thermal Therapy in Patients With Temporal Lobe Epilepsy DOI Creative Commons
Sebastian Johannes Müller, Eya Khadhraoui,

O. Kukhlenko

et al.

Journal of Neuroimaging, Journal Year: 2025, Volume and Issue: 35(2)

Published: March 1, 2025

ABSTRACT Background and Purpose Temporal lobe epilepsy is the most common form of focal epilepsy. MR‐guided laser interstitial thermal therapy (LITT) amygdalohippocampal complex has become an established option in case drug resistance. Long‐term anatomic network effects on brain due to deafferentiation have not yet been evaluated. Methods We analyzed volumes 11 patients with temporal before 1‐year after hippocampal LITT FastSurfer segmenting T1‐weighted data. Additionally, we performed visual ratings measurements. Results A total (7 left‐sided, 4 right‐sided) were included (5 females); mean age years (±standard deviation) at surgery was 41.5 (±18.4) years. The postoperative defect size 1427 (±517) mm 3 . Volumetry as well found a progressive volume loss left‐sided ipsilateral lobe, contralateral (right) part thalamus, especially fusiform cortex. These changes could be detected for right‐sided surgery. Conclusion (partial) ablation left (dominant) hippocampus appears exert long‐term right thalamus cortices. However, observe this effect reverse direction. Volumetric studies larger cohorts should conducted investigate these findings.

Language: Английский

Citations

0