Characterizing the Association Between Blood Urea Nitrogen Levels within the Normal Range and Thyroid Function Among US Adults: NHANES 2007–2012 Findings DOI
Junru Liu,

Xiaofeng Lu,

Xiaotao Zhu

et al.

Hormone and Metabolic Research, Journal Year: 2025, Volume and Issue: 57(02), P. 124 - 133

Published: Feb. 1, 2025

Abstract Blood urea nitrogen (BUN) is a key metric when evaluating the renal function of given patient. Individuals with chronic kidney disease also often present abnormal thyroid functionality. The specific association between BUN and function, however, not well understood. This study was thus developed to explore how levels within normal range are related activity among adults in USA. National Health Nutrition Examination Survey (NHANES) dataset leveraged for these analyses. Linear regression smoothed curve fitting approaches were employed examine measures appropriate weighted subgroup 2007–2012 NHANEs cycles included 6231 eligible from 2.5–8.0 mmol/l. Under adjusted models, higher level associated reductions FT3 (β=–0.01; p=0.047), TT3 (β=–1.08; p=0.003), TT4 (β=–0.10; p=0.003) levels. In analyses, respectively found be negatively correlated subjects who inactive active. These findings consistent reduced FT3, TT4, being American adults. non-physically active subjects, more closely increasing levels, whereas physically subjects. However, additional research will vital clarify mechanisms that underlie results.

Language: Английский

Associations of neutrophil/high-density lipoprotein cholesterol ratio with frailty and its mortality DOI Creative Commons

Jianqiang Zhang

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 6, 2025

Frailty is an increasingly important determinant in the field of health, and its identification has clinical significance critical care medicine. However, there are still a large number challenges quick accurate frailty. This study aims to evaluate value neutrophil/high-density lipoprotein cholesterol ratio (NHR) frailty long-term survival. Adult participants from seven cycles National Health Nutrition Examination Survey (NHANES) database were included. was assessed with 49-item Index (FI). Weighted logistic regression, restricted cubic spline (RCS), Cox regression used analyze association NHR In addition, subgroup interaction analyses also performed. A total 34,382 adult aged 47.6 on average included, 16,950 (48.8%) them males. After adjustment potential confounding variables, increase one standard deviation (SD) resulted incidence by 11% (OR: 1.11, 95% CI: 1.04-1.18, P = 0.002). RCS showed J-shaped between frailty, which robust all subgroups according analysis. survival analysis revealed that significantly positively associated all-cause (HR: 1.12, 1.07-1.17, < 0.0001), cardiocerebrovascular disease (CCD)-specific 1.21, 1.11-1.33, cancer-specific mortality risks 1.13, 1.07-1.19, 0.0001) frail individuals. American population, maintains relationship can help predict demonstrates may become effective predictor mortality.

Language: Английский

Citations

0
Characterizing the Association Between Blood Urea Nitrogen Levels within the Normal Range and Thyroid Function Among US Adults: NHANES 2007–2012 Findings DOI
Junru Liu,

Xiaofeng Lu,

Xiaotao Zhu

et al.

Hormone and Metabolic Research, Journal Year: 2025, Volume and Issue: 57(02), P. 124 - 133

Published: Feb. 1, 2025

Abstract Blood urea nitrogen (BUN) is a key metric when evaluating the renal function of given patient. Individuals with chronic kidney disease also often present abnormal thyroid functionality. The specific association between BUN and function, however, not well understood. This study was thus developed to explore how levels within normal range are related activity among adults in USA. National Health Nutrition Examination Survey (NHANES) dataset leveraged for these analyses. Linear regression smoothed curve fitting approaches were employed examine measures appropriate weighted subgroup 2007–2012 NHANEs cycles included 6231 eligible from 2.5–8.0 mmol/l. Under adjusted models, higher level associated reductions FT3 (β=–0.01; p=0.047), TT3 (β=–1.08; p=0.003), TT4 (β=–0.10; p=0.003) levels. In analyses, respectively found be negatively correlated subjects who inactive active. These findings consistent reduced FT3, TT4, being American adults. non-physically active subjects, more closely increasing levels, whereas physically subjects. However, additional research will vital clarify mechanisms that underlie results.

Language: Английский

Citations

0