Macrophage Pyroptosis in Atherosclerosis: Therapeutic Potential

Acta Biochimica et Biophysica Sinica, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

Atherosclerosis (AS) is a chronic inflammatory disease characterized by the accumulation of lipid-rich plaques in arterial walls, leading to cardiovascular events such as myocardial infarction and stroke. Macrophage pyroptosis, form programmed cell death driven NLRP3 inflammasome caspase-1 activation, plays critical role progression destabilization atherosclerotic plaques. This review explores molecular mechanisms underlying macrophage pyroptosis their significant contributions AS pathogenesis. Recent advancements have highlighted therapeutic potential targeting key components pyroptotic pathway, including use nanotechnology increase drug delivery specificity. These strategies are promising for reducing inflammation, stabilizing plaques, mitigating clinical impact AS. Future studies should focus on translating these findings into applications develop effective treatments that can halt or reverse modulating pyroptosis.

Language: Английский

Neutrophils: a new target for postoperative cognitive dysfunction.

PubMed, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Language: Английский