Cardiac Autonomic Modulation and Cognitive Performance in Community-Dwelling Older Adults: A Preliminary Study DOI Creative Commons
Paula Andreatta Maduro, Luiz Alcides Ramires Maduro, Polyana Evangelista Lima

et al.

Neurology International, Journal Year: 2025, Volume and Issue: 17(5), P. 74 - 74

Published: May 12, 2025

Background/Objectives: Cognitive decline has been increasingly linked to cardiac autonomic regulation; however, its specific associations with cognitive domains, such as information processing speed and executive function, remain unclear. This preliminary study examined the relationship between modulation performance in older adults. Methods: A cross-sectional was conducted 101 adults (aged ≥60 years) attending a university hospital outpatient clinic. Participants were classified without impairment (WCI) or cognitively impaired not demented (CIND) based on neuropsychological assessments. Heart rate variability (HRV) measured at rest, focusing time-domain parameters (SDNN, rMSSD, pNN50). Trail making test parts B (TMT-A TMT-B) used assess respectively. Analyses of covariance (ANCOVAs) performed, adjusting for confounding variables including age, sex, comorbidities. Results: CIND group had significantly lower HRV indices than those WCI p < 0.05, d = 0.44; 0.39; pNN50, 0.40), indicating reduced parasympathetic modulation. Higher values observed individuals preserved function. Specifically, pNN50 associated (p 0.04), SDNN correlated function 0.02). These persisted even after factors. Conclusions: Reduced modulation, especially activity, is Lower slower speed, poorer findings support potential use physiological biomarker detect changes during ageing.

Language: Английский

Cardiac Autonomic Modulation and Cognitive Performance in Community-Dwelling Older Adults: A Preliminary Study DOI Creative Commons
Paula Andreatta Maduro, Luiz Alcides Ramires Maduro, Polyana Evangelista Lima

et al.

Neurology International, Journal Year: 2025, Volume and Issue: 17(5), P. 74 - 74

Published: May 12, 2025

Background/Objectives: Cognitive decline has been increasingly linked to cardiac autonomic regulation; however, its specific associations with cognitive domains, such as information processing speed and executive function, remain unclear. This preliminary study examined the relationship between modulation performance in older adults. Methods: A cross-sectional was conducted 101 adults (aged ≥60 years) attending a university hospital outpatient clinic. Participants were classified without impairment (WCI) or cognitively impaired not demented (CIND) based on neuropsychological assessments. Heart rate variability (HRV) measured at rest, focusing time-domain parameters (SDNN, rMSSD, pNN50). Trail making test parts B (TMT-A TMT-B) used assess respectively. Analyses of covariance (ANCOVAs) performed, adjusting for confounding variables including age, sex, comorbidities. Results: CIND group had significantly lower HRV indices than those WCI p < 0.05, d = 0.44; 0.39; pNN50, 0.40), indicating reduced parasympathetic modulation. Higher values observed individuals preserved function. Specifically, pNN50 associated (p 0.04), SDNN correlated function 0.02). These persisted even after factors. Conclusions: Reduced modulation, especially activity, is Lower slower speed, poorer findings support potential use physiological biomarker detect changes during ageing.

Language: Английский

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