Hippocampal gray matter volume alterations in patients with first-episode and recurrent major depressive disorder and their associations with gene profiles

BMC Psychiatry, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 15, 2025

Recent studies indicate that patients with first-episode drug-naïve (FEDN) and recurrent major depressive disorder (R-MDD) exhibit distinct atrophy patterns in the hippocampal subregions along proximal-distal axis. However, it remains unclear whether such differences occur long axis how they may relate to specific genes. In present study, we analyzed T1-weighted images from 421 (FEDN: n = 232; R-MDD: 189) 544 normal controls (NC) as part of REST-meta-MDD consortium. Additionally, transcriptome maps structural Magnetic Resonance Imaging (MRI) data six donated brains were obtained Allen Human Brain Atlas (AHBA). We first identified changes gray matter volume (GMV) within hippocampus both FEDN R-MDD then integrated these findings AHBA investigate genes associated GMV changes. Compared NC, displayed reduced left tail, whereas exhibited decreased bilateral body increased tail. Further analysis revealed expression levels SYTL2 positively correlated patients, while SORCS3 SLIT2 those R-MDD. Our results suggest alterations subfields differ between R-MDD, reflecting progressive deterioration prolonged depression, potentially supported by These offer valuable insights into neural genetic mechanisms underlying which aid development more targeted effective treatment strategies for MDD subtypes.

Language: Английский

Cerebral perfusion and gray matter volume alterations associated with cognitive impairment in metabolic syndrome with cerebral small vessel disease

Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 17

Published: April 22, 2025

Objective Metabolic syndrome (MetS) combined with cerebral small vessel disease (CSVD) is associated cognitive dysfunction. However, the underlying mechanisms remain poorly understood. This study investigated roles of brain perfusion and gray matter volume (GMV) in dysfunction patients MetS CSVD (MetS-CSVD). Methods enrolled 180 86 healthy controls (HCs). Patients were categorized into without (MetS-NCSVD) ( n = 58) (MetS-CSVD) 122) groups. All participants underwent laboratory tests, neuropsychological assessments, 3D pseudo-continuous arterial spin labeling (3D-PCASL), magnetic resonance imaging scans voxel-based morphometry (VBM). Cerebral blood flow (CBF), GMV, clinical scales analyzed for correlations regions interest (ROIs). The relationships among performance, CBF, GMV evaluated using partial correlation analysis multivariable linear regression (MLRA). Mediation was performed to investigate CBF association between scores performance. Results Compared MetS-NCSVD HC groups, MetS-CSVD group displayed significantly reduced frontal temporal lobes. Partial revealed that frontotemporal lobe strongly overall function, executive language function group. MLRA identified score as sole independent factor negatively lobes mediated relationship function. Conclusion CSVD, rather than individual components MetS, impairment MetS-CSVD. likely contributes indirectly through its effects on these patients.

Language: Английский