Sex difference alters the behavioral and cognitive performance in a rat model of schizophrenia induced by sub-chronic ketamine

Journal of Psychiatric Research, Journal Year: 2024, Volume and Issue: 178, P. 180 - 187

Published: Aug. 11, 2024

Language: Английский

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Hyperhomocysteinemia Increases Cortical Excitability and Aggravates Mechanical Hyperalgesia and Anxiety in a Nitroglycerine-Induced Migraine Model in Rats

Biomolecules, Journal Year: 2022, Volume and Issue: 12(5), P. 735 - 735

Published: May 23, 2022

Homocysteine is a sulfur-containing endogenous amino acid leading to neurotoxic effects at high concentrations. Population studies suggest an association between plasma homocysteine levels and the risk of migraine headaches. The aim this study was analyze sensitivity rats with prenatal hyperhomocysteinemia (hHCY) in respect development behavioral correlates headache spreading cortical depolarization (CSD) model induced by administration nitric oxide (NO) donor nitroglycerin. Animals hHCY were characterized migraine-related symptoms such as mechanical hyperalgesia, high-level anxiety, photophobia, well enhanced level neuronal activity somatosensory cortex along lower threshold CSD generation. Likewise, acute or chronic intermittent nitroglycerin also allodynia, photophobia anxiety control groups. However, these more pronounced hHCY. Unlike hHCY, did not affect generation, but like increased background layers 2/3 4 cerebral cortex. latter animals Thus, profile associated can be further exaggerated conditions triggering gaseous transmitter NO. Our data are consistent view that act factor for migraine.

Language: Английский

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Genetic predisposition to Alzheimer's disease alters inflammasome activity after traumatic brain injury

Translational research, Journal Year: 2023, Volume and Issue: 257, P. 66 - 77

Published: Feb. 8, 2023

Traumatic Brain Injury (TBI) is a major cause of death and disability in the US recognized risk factor for development Alzheimer's disease (AD). The relationship between these conditions not completely understood, but may share additive or synergistic pathological hallmarks that serve as novel therapeutic targets. Heightened inflammasome signaling plays critical role pathogenesis central nervous system injury (CNS) release apoptosis-associated speck-like protein containing caspase recruitment domain (ASC) speck from neurons activated microglia contribute significantly to TBI AD pathology. This study investigated whether after was augmented this pathway impacted biochemical neuropathological outcomes overall cognitive function. Five-month-old, 3xTg mice respective wild type controls were randomized underwent moderate controlled cortical impact (CCI) served sham/uninjured controls. Animals sacrificed at 1 hour, day, week assess acute pathology 12 weeks assessing ipsilateral cerebral cortex processed expression by immunoblotting. Mice evaluated behavior open field (3 days), object recognition (2 weeks), Morris water maze (6 weeks) testing TBI. There statistically significant increase proteins Caspase-1, Caspase-8, ASC, interleukin (IL)-1β both animals. At 1-day post injury, increases ASC IL-1β measured compared WT Behavioral showed injured had altered function when mice. Elevated Aβ seen hippocampus sham groups injury. Moreover, treatment with IC100, an anti-ASC monoclonal antibody, inhibited inflammasome, evidenced reduction 1-week These findings show response heightened genetically predisposed suggests exacerbate Thus, dampening offer approach

Language: Английский

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The BDNF mimetic R-13 attenuates TBI pathogenesis using TrkB-related pathways and bioenergetics

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2023, Volume and Issue: 1869(7), P. 166781 - 166781

Published: June 5, 2023

Language: Английский

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Barnes maze test for spatial memory: A new, sensitive scoring system for mouse search strategies

Behavioural Brain Research, Journal Year: 2023, Volume and Issue: 458, P. 114730 - 114730

Published: Oct. 26, 2023

The Barnes maze is a task used to assess spatial learning and memory in rodents. It requires animals learn the position of hole that can be as an escape from bright open arena. often-used parameters latency path length measure do not reflect different navigation strategies chosen by animals. Here, we propose 11-point scoring scheme classify search developed during initial training well after change target new position. Strategy scores add important dimension time behavior this popular maze.

Language: Английский

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Transforming semitransparent organic photovoltaics into catalysts for positive emotional responses

Applied Physics Letters, Journal Year: 2025, Volume and Issue: 126(7)

Published: Feb. 17, 2025

Semitransparent organic photovoltaics (ST-OPVs), due to their transparency, can be integrated into building designs through (BIPVs) address the energy challenges posed by urbanization. While current BIPVs such as photovoltaic windows meet criteria for both power supply and urban esthetics, a crucial aspect remains underexplored in existing research: human experience under modulated sunlight. In this study, we conduct systematic analysis of interaction between spectrally tunable ST-OPV materials cognition emotion, proposing framework selecting user-friendly ST-OPVs. Our results reveal that predominant high-performance donor polymer negatively influence user emotions. To issue, employed spectrum shaping optical structures optimize device transmittance color rendering properties, achieve desirable emotion feedback. This groundbreaking study delves devices, playing role addressing demands urbanization paving way realization smart, sustainable, healthy cities.

Language: Английский

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The role of isolated diffuse axonal brain injury on post-traumatic depressive- and anxiety-like behavior in rats

Translational Psychiatry, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 31, 2025

Traumatic brain injury (TBI) is a significant global health concern and associated with short-term long-term comorbidities such as mood disorders reduced quality of life. Diffuse axonal (DABI) common but severe type TBI. The role DABI in the development psychiatric sequelae after TBI not well understood due to challenge isolating from general human population. Here we investigate occurrence post-TBI depressive- anxiety-like behaviors rat model. Forty rats were randomly assigned two groups, 20 receiving sham treatment. We used magnetic resonance imaging (MRI) protocol developed for using 3-T clinical scanner confirm DABI. then compared neuroimaging, neurological behavioral assessments across experimental groups. There was difference between groups on sucrose preference, measurement depressive-like behavior (p < 0.012), time spent open arms plus maze test, 0.032). For MRI-detected injury, there diffusion-weighted relative anisotropy 0.001) fractional mapping. found that isolated our model led post-traumatic 30% cases 35%. Additionally, established diagnostic cut-offs injured rats. also documented comorbidity depression anxiety DABI-exposed anticipate this study will greatly enhance understanding relationship DABI, TBI, like anxiety, aid developing treatment options these interconnected conditions.

Language: Английский

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Traumatic brain injury-induced submissive behavior in rats: link to depression and anxiety

Translational Psychiatry, Journal Year: 2022, Volume and Issue: 12(1)

Published: June 7, 2022

Traumatic brain injury (TBI) affects millions of people worldwide, many whom are affected with post-TBI mood disorders or behavioral changes, including aggression social withdrawal. Diminished functionality can persist for decades after TBI and delay rehabilitation resumption employment. It has been established that there is a relationship between these mental injury. However, the etiology causal relationships behind conditions poorly understood. Rodent models provide helpful tool researching impairment due to their natural tendencies form hierarchies. Here, we present rat model complications using suite tests examine changes in behavior, aggressive, hierarchical, depressive, anxious behavior. For this purpose, used multivariate analysis identify above psychiatric sequelae. We performed statistical principal component analysis, discriminant correlation built predict dominant-submissive behavior based on tests. This displayed predictive accuracy 93.3% determining experimental groups. Machine learning algorithms determined rats, not prognostic factor Alternatively, solely by rats' depressive-anxious state exploratory activity. expect approach study will guide future studies into following TBI.

Language: Английский

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Saffron extract (Safr'Inside™) improves anxiety related behaviour in a mouse model of low-grade inflammation through the modulation of the microbiota and gut derived metabolites

Food & Function, Journal Year: 2022, Volume and Issue: 13(23), P. 12219 - 12233

Published: Jan. 1, 2022

Treatment of anxiety and depression predominantly centres around pharmacological interventions, which have faced criticism for their associated side effects, lack efficacy low tolerability. Saffron, is reportedly well tolerated in humans, has been recognised its antidepressant anti-anxiety properties. Indeed, we previously reported upon the saffron extract supplementation healthy adults with subclinical anxiety. However, molecular aetiology remains unclear. In a rodent model low-grade chronic inflammation, explored impact (Safr'Inside™) supplemented at physiological dose, equated to 22 ± 1.2 mg per day human equivalent dose person 60 kg. Behavioural tests (Open Field task, Y maze, Novel object recognition), caecal 16S rRNA microbial sequencing, 1H NMR metabolomic analysis 2DE brain proteomic analyses were completed probe gut-brain axis interactions. Time occupying centre Open maze (OF) was increased by 62% animals. This improvement anxiety-related behaviour coincided gut shifts, notably Akkermansia, Muribaculaceae, Christensenellacae Alloprevotella significantly response supplementation. Akkermansia Muribaculaceae abundance negatively correlated neurotoxic metabolite dimethylamine reduced Brain highlighted several altered proteins including ketimine reductase mu-crystallin also concentration. Both OF performance. may be indicative novel interaction across contributes disorders.

Language: Английский

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The Effects of Indirect and Direct Modulation of Endocannabinoid System Function on Anxiety-Related Behavior in Mice Assessed in the Elevated Plus Maze Test

Molecules, Journal Year: 2025, Volume and Issue: 30(4), P. 867 - 867

Published: Feb. 13, 2025

The endocannabinoid system (ECS) is one of the most important systems modulating functions in body. ECS, via cannabinoid (CB: CB1 and CB2) receptors, endocannabinoids occurring brain (e.g., anandamide (AEA) 2-arachidonoylglycerol (2-AG)) enzymes degrading (fatty-acid amide hydrolase (FAAH) monoacylglycerol lipase (MAGL)), plays a key role regulation mood anxiety. However, effects compounds on anxiety-related responses are complex yield mixed results depending type pharmacological manipulation (direct or indirect) as well kinds cannabinoids, dosage procedure. aim this study was to determine compare influence direct (via CB receptors ligands) indirect inhibition brain) modulation ECS function anxiety-like mice elevated plus maze (EPM) test. For purpose, first step experiments, we used selected ligands CB1, CB1/CB2 CB2 assess which types involved mice. Next, inhibitors FAAH (which breaks down AEA) MAGL 2-AG) more responsible for behavior our presented research showed that an acute administration receptor agonist oleamide (5-20 mg/kg) had no antagonist AM 251 (0.25-3 anxiogenic EPM test In turn, WIN55,212-2 at dose 1 mg/kg anxiolytic effect observed What interest both (JWH 133 doses 2 (AM 630 0.5-2 Moreover, revealed only inhibitor URB 597 (0.3 effect, while JZL 184 (at any (2-40 mg/kg)) after injection anxiety mice, confirmed clearly significant involvement responses. particular, able elicit promising effects. Therefore, could be potential target novel drugs; however, further studies needed.

Language: Английский

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