Impulsivity behaviors and white matter mediate the relationship between genetic risk for cannabis use disorder and early cannabis use in adolescents

Addiction, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract Background and Aim Cannabis use disorder (CUD) is strongly influenced by genetic factors; however the mechanisms underpinning this association are not well understood. This study investigated whether a polygenic risk score (PRS) based on genome‐wide for CUD in adults predicts cannabis adolescents can be explained inter‐individual variation structural properties of brain white matter or risk‐taking behaviors. Design setting Longitudinal cross‐sectional analyses using data from IMAGEN cohort, European longitudinal integrating genetic, neuroimaging behavioral measures. We measured associations between PRS CUD, novelty sensation seeking traits fractional anisotropy (FA) tracts. Mediation modeling explored FA mediated use. Participants were assessed at 14 ( n = 1762), 19 1175) 23 1139) years old. Measurements School Survey Project Alcohol Other Drugs, substance profile scale, Fagerstrom Test Nicotine Dependence, temperament character inventory, Kirby Monetary Questionnaire, diffusor tensor imaging CUD‐PRS. Findings CUD‐PRS was associated with adolescent total exposure [ P < 0.001, beta 0.098 (95% confidence interval 0.059, 0.137)] as other measures [alcohol 0.002, 0.058 (0.020, 0.096); cigarettes smoked 0.086 (0.044, 0.128); fargestrom 0.062 (0.028, drug 0.106 (0.065, 0.147)]. also impulsivity, behaviors [impulsivity (0.060, 0.142); 0.094 (0.0523, 0.1357); 0.105 (0.064, 0.146); discounting task 0.051 (0.013, 0.089)] average −0.010 (−0.015, −0.005)]. mediation models showed that these could mediate [overall indirect effect 0.048 0.068); impulsivity 0.016, 0.019 (0.004, 0.035); 0.034 (0.017, 0.05)]. Conclusions The adult appears to behavior structure early age 14. observed consistent notion increases way leads more adolescents.

Language: Английский

Cannabis Use is Related to Anhedonia in Adolescents With Diverse Mood and Anxiety Symptoms

JAACAP Open, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

A Systematic Review: Investigating Biomarkers of Anhedonia and Amotivation in Depression and Cannabis Use

JAACAP Open, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский