Preoperative Biofluid Biomarkers for Predicting Postoperative Neurocognitive Disorders in Older Adults: A Systematic Review DOI
Ming Ann Sim, Helen Wilding, Kelly J. Atkins

et al.

Anesthesia & Analgesia, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 21, 2024

Preoperative biofluid biomarkers reflecting pathophysiological, neuronal injury, and inflammation as well those for Alzheimer's disease (AD) may be valuable tools the risk stratification of perioperative neurocognitive disorders (PNDs) in older adults. We summarized current evidence relating these preoperative to PND beyond 7 days, surgical participants aged ≥60 years. Studies that evaluated association with cognitive decline an outcome, were identified through searches 6 databases 3 trial registries 17 January 2024. Preclinical studies, intracranial surgical, or studies <60 years excluded. varied widely assessment PND, so a wide range outcomes was accepted, including using term postoperative dysfunction (POCD) define decline. The pooled incidence POCD utilizing binary outcome summarized. Fifteen involving 2103 included. Marked heterogeneity evident metrics, timeframes, limiting quantitative synthesis. Of 9 binarized outcomes, 23.4% (95% confidence interval [CI], 6.6-46.2) at <3 months, 11.4% CI, 8.1-15.0) <12 6.9% 1.9-14.5) ≥12 months postoperatively. 15 described blood-based biomarkers, 4 cerebrospinal fluid (CSF) 2 measured both blood CSF markers. reflected pathogenic indicators injury (9 studies), (5 studies) amyloid Tau (1 study). included medium high quality. Evidence most promising 5 demonstrating associations lower biomarker levels increased POCD. In conclusion, hold potential utility prediction POCD, although remains limited. Other p-Tau181 Neurofilament Light, however small sample sizes, study heterogeneity, conflicting results limited conclusions drawn. Standardized metrics common timeframes are additionally required future ascertain prognostic

Language: Английский

Recent Advances in the Mechanisms of Postoperative Neurocognitive Dysfunction: A Narrative Review DOI Creative Commons
Tingting Wang, Xin Huang, Shujun Sun

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(1), P. 115 - 115

Published: Jan. 7, 2025

Postoperative neurocognitive dysfunction (PND) is a prevalent and debilitating complication in elderly surgical patients, characterized by persistent cognitive decline that negatively affects recovery quality of life. As the aging population grows, rising number patients has made PND an urgent clinical challenge. Despite increasing research efforts, pathophysiological mechanisms underlying remain inadequately characterized, underscoring need for more integrated framework to guide targeted interventions. To better understand molecular therapeutic targets PND, this narrative review synthesized evidence from peer-reviewed studies, identified through comprehensive searches PubMed, Embase, Cochrane Library, Web Science. Key findings highlight neuroinflammation, oxidative stress, mitochondrial dysfunction, neurotransmitter imbalances, microvascular changes, white matter lesions as central pathophysiology, with particular parallels encephalocele- sepsis-associated impairments. Among these, mediated pathways such NLRP3 inflammasome blood-brain barrier disruption, emerges pivotal driver, triggering cascades exacerbate neuronal injury. Oxidative stress synergistically amplify these effects, while imbalances alterations, including lesions, contribute synaptic decline. Anesthetic agents modulate interconnected pathways, exhibiting both protective detrimental effects. Propofol dexmedetomidine demonstrate neuroprotective properties suppressing neuroinflammation microglial activation, whereas inhalational anesthetics like sevoflurane intensify inflammatory responses. Ketamine, its anti-inflammatory potential, offers promise but requires further evaluation determine long-term safety efficacy. By bridging insights practice, highlights critical role personalized anesthetic strategies mitigating improving patients. It aims inform future decision-making address multifaceted

Language: Английский

Citations

2
Role of dexmedetomidine in postoperative cognitive dysfunction and sleep improvement in aged rats by regulating the PI3K/Akt signaling pathway and its mechanism DOI
Ying Kong,

Xiaopeng Wang,

Jun Pang

et al.

Brain Research, Journal Year: 2025, Volume and Issue: unknown, P. 149482 - 149482

Published: Jan. 1, 2025

Language: Английский

Citations

1
The Role and Mechanisms of Ubiquitin-Proteasome System-Mediated Ferroptosis in Neurological Disorders DOI
Xin Liu, Wei Wang,

Qunhua Nie

et al.

Neuroscience Bulletin, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Language: Английский

Citations

0
The role of clock control of DRP1 activity involved in postoperative cognitive dysfunction DOI
Yin Cui,

Zhiying Zheng,

Qingyun Zhou

et al.

Experimental Neurology, Journal Year: 2025, Volume and Issue: 385, P. 115140 - 115140

Published: Jan. 7, 2025

Language: Английский

Citations

0
Clinical Management of Patients with Severe Post-Operative Pulmonary Complications DOI
Inès Lakbar, Mathieu Capdevila, Joris Pensier

et al.

Current anesthesiology reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 11, 2025

Language: Английский

Citations

0
The immune-inflammatory responses on the hypothalamic-pituitary-adrenal axis and the neurovascular unit in perioperative neurocognitive disorder DOI
So Yeong Cheon,

M Cho,

So Yeon Kim

et al.

Experimental Neurology, Journal Year: 2025, Volume and Issue: 386, P. 115146 - 115146

Published: Jan. 11, 2025

Language: Английский

Citations

0
Effect of central sensitization on postoperative cognitive dysfunction in total knee arthroplasty patients: a retrospective study DOI Creative Commons
Qiqi Yang,

Chunning Li,

Min Ye

et al.

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 15, 2025

Postoperative cognitive dysfunction (POCD) is a common complication after total knee arthroplasty (TKA), impacting recovery and quality of life. This study aims to investigate central sensitization (CS) as an independent risk factor for POCD improve preoperative screening postoperative interventions. A retrospective analysis was conducted on 142 TKA patients from January 2020 May 2024 across three hospitals. Data were collected at six time points: preoperatively (T0), intraoperatively (T1), postoperatively days 1 (T2), 3 (T3), 7 (T4), 30 (T5). Patients classified into CS (CSI ≥ 40) non-CS < groups according Central Sensitization Inventory (CSI) score. Cognitive function incidence assessed with the Mini-Mental State Examination (MMSE), Knee Injury Osteoarthritis Outcome Score (KOOS). Logistic regression used identified factors POCD. The overall T5 19.72%, significantly higher rate in group (30.91%) compared (12.64%) (p = 0.008). MMSE scores declined both T2 T3 T0 0.05), showing consistently lower than T2-T5 0.05). KOOS revealed that had worse pain life T0, T4, CS, cerebrovascular disease, intraoperative hemorrhage, associated significant following TKA, adversely affecting terms Prospective studies are warranted validate findings develop targeted

Language: Английский

Citations

0
Hyperbaric oxygen therapy for cardiovascular surgery DOI

D Wang,

Mo Liu, Shuo Jia

et al.

Medical Gas Research, Journal Year: 2025, Volume and Issue: 15(2), P. 299 - 308

Published: Jan. 20, 2025

Common cardiovascular surgeries include coronary artery bypass grafting, cardiac valve replacement, radiofrequency ablation, and intervention surgery. Multiple postoperative complications, such as hypoxic encephalopathy, air embolism, retained intracardiac air, cognitive dysfunction major adverse events, including heart failure, ischemic stroke, myocardial infarction, may occur after these surgeries. Hyperbaric oxygen can be used in preconditioning to lower the morbidity of complications. It is also effective for treatment numerous We provide evidence from current literature highlighting use hyperbaric therapy managing

Language: Английский

Citations

0
Neutrophils: a new target for postoperative cognitive dysfunction. DOI
Jianxin Cheng, Jin Gao, Jianjun Li

et al.

PubMed, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Language: Английский

Citations

0
The regulatory mechanism of intermittent fasting and probiotics on cognitive function by the microbiota‐gut‐brain axis DOI
Yili Chen, Chi‐Tang Ho, Xin Zhang

et al.

Journal of Food Science, Journal Year: 2025, Volume and Issue: 90(3)

Published: March 1, 2025

Abstract Intermittent fasting (IF) is an eating pattern that promotes health and cognitive improvement through periodic eating. It has been shown to enhance neuroplasticity reduce oxidative stress inflammation. Recent studies have demonstrated probiotic supplementation enhances performance by modulating gut microbiota composition increasing short‐chain fatty acid production, which in turn neurogenesis synaptic plasticity. The microbiota‐gut‐brain axis (MGBA) the communication bridge between brain, influencing function immune, endocrine, nervous systems. combination of probiotics IF may exert complementary effects on function, with enhancing microbial diversity metabolic efficiency, while further modulate barrier integrity neurotransmitter synthesis. This review critically examines interplay via MGBA, identifying key mechanisms potential therapeutic strategies remain underexplored current research.

Language: Английский

Citations

0