Neural oscillations in the ventral striatum reveal differences between the encoding of palatable food and ethanol consumption DOI
Lucas L. Dwiel, Angela M. Henricks,

Elise M. Bragg

et al.

Alcohol Clinical and Experimental Research, Journal Year: 2023, Volume and Issue: 47(7), P. 1327 - 1340

Published: May 11, 2023

Across multiple levels of investigation, there appear to be convergent neuronal processes underlying substance use and other motivated behaviors (i.e., the pursuit consumption rewarding substances). The alcohol sweet, high-fat food engages many same brain regions, especially, ventral striatum. In current study, we hypothesized that striatal local field potentials (LFPs) recorded during self-administration sessions could used detect when 10% ethanol or sweet-fat (SF) was occurring compared all behaviors, including naturalistic controls water house-chow).

Language: Английский

Mechanisms of nucleus accumbens deep brain stimulation in treating mental disorders DOI Creative Commons
Hanyang Ruan, Geya Tong, Minghui Jin

et al.

Fundamental Research, Journal Year: 2024, Volume and Issue: 5(1), P. 48 - 54

Published: July 6, 2024

Growing evidence supports the effectiveness of deep brain stimulation (DBS) in treating various psychiatric disorders. DBS has potential to selectively stimulate specific subcortical areas thus providing high-frequency electric these regions. The nucleus accumbens (NAc), a frequent target, shown promise conditions like depression, obsessive-compulsive disorder, and addiction. In this review, we provide an overview across studies investigating effects NAc humans animals discuss mechanisms underlying its clinical efficacy. We address anatomical properties discuss, particular, frequently reported differential shell core DBS. Moreover, by outlining cell types, transmitter systems (i.e., predominantly GABAergic dopaminergic systems) pathways that have been be relevant for effects, aim further elucidate neurobiological determinants Finally, since treatment are most probably also related alterations connected circuits or networks, review focusing on investigation network effects. By examining components assumed relevance context DBS, will hopefully contribute increasing our knowledge about optimizing future selection optimal targets.

Language: Английский

Citations

4
Examining mitochondrial genetic variation in obsessive-compulsive disorder DOI Creative Commons
Vanessa F. Gonçalves, Fernanda Caroline dos Santos, Stavroula Giannoulis

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Abstract Obsessive-compulsive disorder (OCD) is a severe neuropsychiatric with clear evidence of genetic vulnerability, although specific risk factors are not fully understood. Mitochondrial dysfunction has been implicated in other disorders, particularly through its role oxidative stress, and thus merits exploration OCD. Here we first examined the association set 59 mitochondrial single nucleotide polymorphisms (SNPs) OCD symptom severity. These SNPs located inside 28 nuclear-encoded genes involved phosphorylation, biogenesis, inflammation, apoptosis. We used linear regression to test for this SNP severity using Yale-Brown Obsessive Compulsive Scale (YBOCS). found nominally significant rs3820189 5’ MFN2 gene YBOCS total score (N = 346; Puncorrected= 0.002). also conducted gene-based gene-set (pathway) analyses on pathways MAGMA. ADCK1 be associated (p 0.00005, q 0.05). No were risk. To further examine variation risk, then (mt) DNA (mtDNA), circular genome each mitochondrion. utilized Toronto sample 215) 1000 Genome Project 485) as healthy controls discovery. For replication, compared individual-level data from Psychiatric Genomics Consortium (PGC) Working Group release 2017 1691) Wellcome Trust 2616) controls. After cleaning, 58 common mtDNA (minor allele frequency greater than 1%) available analysis. Meta-analysis across variants shared between both samples revealed five significantly which survived Nyholt correction: NC_012920.1:m.1719G > A (P 1.489E-05), NC_012920.1:m.3010G 2.423E-05), NC_012920.1:m.10398A G 3.172E-04), NC_012920.1:m.11914G 6.085E-04) NC_012920.1:m.6260G 7.792E-04). best our knowledge, largest study report involvement Further investigations validation findings warranted.

Language: Английский

Citations

0
Codes between Poles: Linking Transcriptomic Insights into the Neurobiology of Bipolar Disorder DOI Creative Commons
Jon Patrick T. Garcia, Lemmuel L. Tayo

Biology, Journal Year: 2024, Volume and Issue: 13(10), P. 787 - 787

Published: Sept. 30, 2024

Bipolar disorder (BPD) is a serious psychiatric condition that characterized by the frequent shifting of mood patterns, ranging from manic to depressive episodes. Although there are already treatment strategies aim at regulating manifestations this disorder, its etiology remains unclear and continues be question interest within scientific community. The development RNA sequencing techniques has provided newer better approaches studying disorders transcriptomic level. Hence, using RNA-seq data, we employed intramodular connectivity analysis network pharmacology assessment disease-associated variants elucidate biological pathways underlying complex nature BPD. This study was intended characterize expression profiles obtained three regions in brain, which nucleus accumbens (nAcc), anterior cingulate cortex (AnCg), dorsolateral prefrontal (DLPFC), provide insights into specific roles these onset present potential targets for drug design development. nAcc found highly associated with genes responsible deregulated transcription neurotransmitters, while DLPFC greatly correlated involved impairment components crucial neurotransmission. AnCg did show association some expressions, but relationship not as strong other two regions. Furthermore, or single nucleotide polymorphisms (SNPs) were identified among significant BPD, suggests genetic interrelatedness such mental illnesses. DRD2, GFRA2, DCBLD1 expressed nAcc; ST8SIA2 ADAMTS16 AnCg; FOXO3, ITGA9, CUBN, PLCB4, RORB DLPFC. Aside unraveling molecular cellular mechanisms behind investigation envisioned propose new research pipeline transcriptome support improve existing studies.

Language: Английский

Citations

1
Dysconnectivity of the Nucleus Accumbens and Amygdala in Youths with Thought Problems: A Dimensional Approach DOI

Chen-Fang Chung,

Jules R. Dugré, Stéphane Potvin

et al.

Brain Connectivity, Journal Year: 2024, Volume and Issue: 14(4), P. 226 - 238

Published: March 25, 2024

Background: Youths with thought problems (TP) are at risk to develop psychosis and obsessive-compulsive disorder (OCD). Yet, the pathophysiological mechanisms underpinning TP is still unclear. Functional magnetic resonance imaging (fMRI) studies have shown that striatal limbic alterations associated psychosis-like obsessive-like symptoms in individuals clinical for psychosis, schizophrenia, OCD patients. More specifically, Nucleus accumbens (NAcc) amygdala mainly involved these associations. The current study aims investigate neural correlates of youth populations using a dimensional approach explore potential cognitive functions neurotransmitters it. Methods: Seed-to-voxels functional connectivity analyses NAcc as regions-of-interest was conducted resting-state fMRI data obtained from 1360 young individuals, confounders related such anxiety were included covariates multiple regression analyses. Replicability tested adult cohorts. Additionally, decoding neurochemical correlation performed identify neurotransmitters. Results: altered between right posterior parahippocampal gyrus, lateral prefrontal cortex, left visual cortex areas 2 (V2) best predictors model. These connections social cognition reward processing. Conclusions: Our results show pathways processing severity youths.

Language: Английский

Citations

0
Dopamine Release Dynamics in the Nucleus Accumbens Are Modulated by the Timing of Electrical Stimulation Pulses When Applied to the Medial Forebrain Bundle and Medial Prefrontal Cortex DOI

Andrea R. Hamilton,

Abhilasha Vishwanath, Nathan C. Weintraub

et al.

ACS Chemical Neuroscience, Journal Year: 2024, Volume and Issue: 15(14), P. 2643 - 2653

Published: July 3, 2024

Electrical brain stimulation has been used in vivo and vitro to investigate neural circuitry. Historically, parameters such as amplitude, frequency, pulse width were varied their effects on neurotransmitter release behavior. These experiments have traditionally employed fixed-frequency patterns, but it previously found that neurons are more precisely tuned variable input. Introducing variability into the interpulse interval of pulses will inform how dopaminergic can be modulated by timing. Here, rats is monitored nucleus accumbens (NAc), a key center which plays role learning motivation, fast-scan cyclic voltammetry. Dopaminergic NAc could also region due differences connectivity. We targeted two regions for stimulation─the medial forebrain bundle (MFB) prefrontal cortex (mPFC)─due involvement reward processing projections NAc. Our goal patterns delivered these affect time course dopamine stimulating MFB with saw highly responsive, frequency-driven response. In contrast, applied mPFC not sensitive frequency changes. This work help specifically improve efficiency electrical control release.

Language: Английский

Citations

0
Post-mortem Human Brain Analysis of the Ventral pallidum in Alcohol Use Disorder DOI Creative Commons
Ameer Elena Rasool,

Cormac Peat,

Jie Liu

et al.

Addiction Neuroscience, Journal Year: 2024, Volume and Issue: 13, P. 100180 - 100180

Published: Oct. 11, 2024

Language: Английский

Citations

0
Neural oscillations in the ventral striatum reveal differences between the encoding of palatable food and ethanol consumption DOI
Lucas L. Dwiel, Angela M. Henricks,

Elise M. Bragg

et al.

Alcohol Clinical and Experimental Research, Journal Year: 2023, Volume and Issue: 47(7), P. 1327 - 1340

Published: May 11, 2023

Across multiple levels of investigation, there appear to be convergent neuronal processes underlying substance use and other motivated behaviors (i.e., the pursuit consumption rewarding substances). The alcohol sweet, high-fat food engages many same brain regions, especially, ventral striatum. In current study, we hypothesized that striatal local field potentials (LFPs) recorded during self-administration sessions could used detect when 10% ethanol or sweet-fat (SF) was occurring compared all behaviors, including naturalistic controls water house-chow).

Language: Английский

Citations

0