Noradrenergic inputs from the locus coeruleus to anterior piriform cortex and the olfactory bulb modulate olfactory outputs

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 2, 2025

Norepinephrine (NE) released from locus coeruleus (LC) noradrenergic (NAergic) neurons plays a pivotal role in the regulation of olfactory behaviors. However, precise circuits and receptor mechanisms underlying this function are not well understood. Here, DBH-Cre mice model, we show that LC NAergic project directly to both anterior piriform cortex (aPC) bulb (OB). By using pharmacological optogenetic manipulations vitro vivo, found NE reduces excitability aPC pyramidal via α2 receptors it bidirectionally regulates activity OB mitral cells modulation inhibitory inputs. Activation projection reduced spontaneous odor-evoked aPC/OB awake mice, enhanced odor-decoding ability aPC, decreased OB. Furthermore, activation LC–aPC/OB projections accelerated odor discrimination specific inactivation pathway impaired detection discrimination. These findings identify mechanism elucidate its processing play critical roles regulating behaviors, but remain unclear. authors how regulate

Language: Английский

Olfactory neurogenesis plays different parts at successive stages of life, implications for mental health

Frontiers in Neural Circuits, Journal Year: 2024, Volume and Issue: 18

Published: Aug. 8, 2024

The olfactory bulb is a unique site of continuous neurogenesis, primarily generating inhibitory interneurons, process that begins at birth and extends through infancy adulthood. This review examines the characteristics focusing on granule cells, most numerous how their age maturation affect function. Adult-born while immature, contribute to experience-dependent plasticity circuit by enabling structural functional synaptic changes. In contrast, cells born early in life form foundational elements circuit, potentially facilitating innate information processing. implications these neonatal memory impact adult perception, particularly response aversive events susceptibility emotional disorders, warrant further investigation.

Language: Английский

Odor representation and coding by the mitral/tufted cells in the olfactory bulb

Journal of Zhejiang University SCIENCE B, Journal Year: 2024, Volume and Issue: 25(10), P. 824 - 840

Published: Oct. 1, 2024

Language: Английский