A Sideroflexin/Connexin adaptor ties kinesin-3 to mitochondria in neurons DOI Creative Commons
Syed Nooruzuha Barmaver, Oliver I. Wagner

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: June 9, 2023

Abstract We identified SFXN-1.2 to regulate both morphologies as well dynamics of mitochondria. is an ortholog human Sideroflexin 1/3 associated with Alzheimer's and Parkinson's disease. show that binds kinesin-3 KIF1A(UNC-104) via CX32 (Connexin 32), a protein known be linked Charcot-Marie-Tooth diseases. While affect the mitochondria, they also motility molecular motor UNC-104 alone. found no role motor's PH domain in linking has effect on synaptic vesicle trafficking underlining specificity its mitochondria transport. narrowed down critical interaction schemes UNC-104/CX32/SFXN-1.2 complex. Strikingly, mutations lead motor- sensory neuron defects C. elegans affecting animal's touch responses restricting body movements. Lastly, we revealed neither mitochondrial bioenergetics nor mitophagy are affected by sfxn-1.2 mutation.

Language: Английский

The role of RGC degeneration in the pathogenesis of glaucoma DOI

Zhibo Si,

Yuhang Fan, Mingxuan Wang

et al.

International Journal of Biological Sciences, Journal Year: 2024, Volume and Issue: 21(1), P. 211 - 232

Published: Dec. 11, 2024

Glaucoma is a neurodegenerative disorder marked by the loss of retinal ganglion cells (RGCs) and axonal degeneration, resulting in irreversible vision impairment. While intraocular pressure (IOP) presently acknowledged as sole modifiable risk factor, sensitivity RGCs to IOP varies among individuals. Consequently, progressive may ensue even when effectively managed. This review consolidates current knowledge regarding pathogenesis glaucoma various diseases. It delves into mechanisms underlying RGC transsynaptic degeneration defects from pathophysiological standpoint, it elucidates alterations visual pathway throughout progression disease. Furthermore, article outlines neuroprotective nerve regeneration strategies aimed at restoration patients, offers insights for clinical management condition, investigates prospective avenues gene therapy.

Language: Английский

Citations

0
A Sideroflexin/Connexin adaptor ties kinesin-3 to mitochondria in neurons DOI Creative Commons
Syed Nooruzuha Barmaver, Oliver I. Wagner

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: June 9, 2023

Abstract We identified SFXN-1.2 to regulate both morphologies as well dynamics of mitochondria. is an ortholog human Sideroflexin 1/3 associated with Alzheimer's and Parkinson's disease. show that binds kinesin-3 KIF1A(UNC-104) via CX32 (Connexin 32), a protein known be linked Charcot-Marie-Tooth diseases. While affect the mitochondria, they also motility molecular motor UNC-104 alone. found no role motor's PH domain in linking has effect on synaptic vesicle trafficking underlining specificity its mitochondria transport. narrowed down critical interaction schemes UNC-104/CX32/SFXN-1.2 complex. Strikingly, mutations lead motor- sensory neuron defects C. elegans affecting animal's touch responses restricting body movements. Lastly, we revealed neither mitochondrial bioenergetics nor mitophagy are affected by sfxn-1.2 mutation.

Language: Английский

Citations

0