Ramelteon coordinates theta and gamma oscillations in the hippocampus for novel object recognition memory in mice DOI Creative Commons
Kazuya Takeda, Kenji Watanabe,

S Iijima

et al.

Journal of Pharmacological Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Object recognition memory is an animal's ability to discriminate between novel and familiar items supported by neural activities in not only the perirhinal cortex but also hippocampus prefrontal cortex. Since we previously demonstrated that ramelteon enhanced object mice, sought correlates of improvement. We recorded activity mice while they performed a task. found theta oscillations were when ramelteon-treated explored both objects. Moreover, showed high coherence phases at low gamma frequencies assume enhancement indicative increased cholinergic melatonin receptor activation. High hippocampal network sampling objects suggests better cognitive operations for discrimination novelty familiarity. The current study sheds light upon physiological consequences activation, further contributing improved functions.

Language: Английский

Synchronization-suppressing stimulation of the amygdala circuitry reduces pathological anxiety in sub-chronic stress rat model DOI Creative Commons

Larissa Altoé Réboli,

Vinícius Rosa Cota

Published: Jan. 1, 2025

Language: Английский

Citations

0
The role of neuroinflammation in PV interneuron impairments in brain networks; implications for cognitive disorders DOI

Pantea Allami,

Niloufar Yazdanpanah,

Nima Rezaei

et al.

Reviews in the Neurosciences, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Abstract Fast spiking parvalbumin (PV) interneuron is an inhibitory gamma-aminobutyric acid (GABA)ergic diffused in different brain networks, including the cortex and hippocampus. As a key component of PV interneurons collaborate fundamental functions such as learning memory by regulating excitation inhibition (E/I) balance generating gamma oscillations. The unique characteristics interneurons, like their high metabolic demands long branching axons, make them too vulnerable to stressors. Neuroinflammation one most significant stressors that have adverse, long-lasting impact on interneurons. affects through specialized inflammatory pathways triggered cytokines tumor necrosis factor (TNF) interleukin 6 (IL-6). crucial cells neuroinflammation, microglia, also play role. destructive effect inflammation can comprehensive effects cause neurological disorders schizophrenia, Alzheimer’s disease (AD), autism spectrum disorder (ASD), bipolar disorder. In this article, we provide review mechanisms which neuroinflammation leads hypofunction these diseases. integrated knowledge about role cognitive networks involved impairment pathology diseases help us with better therapeutic interventions.

Language: Английский

Citations

0
The Role of Perineuronal Nets in Physiology and Disease: Insights from Recent Studies DOI Creative Commons

Sophia Auer,

Martin Schicht, Lucas Hoffmann

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(5), P. 321 - 321

Published: Feb. 20, 2025

Perineuronal nets (PNNs) are specialized extracellular matrix structures that predominantly surround inhibitory neurons in the central nervous system (CNS). They have been identified as crucial regulators of synaptic plasticity and neuronal excitability. This literature review aims to summarize current state knowledge about PNNs, their molecular composition structure, well functional roles involvement neurological diseases. Furthermore, future directions PNN research proposed, therapeutic potential targeting PNNs develop novel treatment options for various disorders is explored. emphasizes importance CNS physiology pathology underscores need further this area.

Language: Английский

Citations

0
Pharmacological reduction of reverse-translated hippocampal hyperactivity in mouse: relevance for psychosis DOI
F. Dybowski,

Daniel S. Scott,

Carol A. Tamminga

et al.

Neuropsychopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Language: Английский

Citations

0
Neurophysiological Treatment Effects of Mesdopetam, Pimavanserin and Amantadine in a Rodent Model of Levodopa‐Induced Dyskinesia DOI Creative Commons
Abdolaziz Ronaghi,

Tiberiu Loredan Stan,

Sebastián A. Barrientos

et al.

European Journal of Neuroscience, Journal Year: 2025, Volume and Issue: 61(5)

Published: March 1, 2025

Levodopa provides effective symptomatic treatment for Parkinson's disease. However, nonmotor symptoms are often insufficiently relieved, and its long-term use is complicated by motor fluctuations dyskinesia. To clarify mechanisms of levodopa-induced dyskinesia pharmacological interventions aimed at reducing dyskinetic symptoms, we have here characterized the neurophysiological activity patterns in sensorimotor cognitive-limbic circuits rats, comparing effects amantadine, pimavanserin, novel prospective antidyskinetic antipsychotic mesdopetam. Parallel recordings local field potentials from 11 cortical subcortical regions revealed suppression narrowband gamma oscillations (NBGs) structures amantadine mesdopetam conjunction with alleviation signs. Concomitant were not directly linked to affected treatments same extent, although treatment-induced reductions functional coupling observed both circuits, parallel. In a broad frequency spectrum (1-200 Hz), displayed greater similarities pimavanserin than amantadine. These findings point reduction NBGs as valuable biomarker characterization provide systems-level mechanistic insights into efficacy mesdopetam, potential additional benefits Parkinson's-related psychosis.

Language: Английский

Citations

0
Allopregnanolone in the Pathogenesis of the Psychiatric Comorbidities of Polycystic Ovarian Syndrome DOI
Karis I. Sarkisian,

Jane Yang,

Christine Marshall

et al.

The Journal of Steroid Biochemistry and Molecular Biology, Journal Year: 2025, Volume and Issue: unknown, P. 106719 - 106719

Published: March 1, 2025

Language: Английский

Citations

0
Circuit-specific neural perturbations and recovery in methamphetamine addiction in a mouse model DOI

Pongpanot Wongveerakul,

Dania Cheaha,

Ekkasit Kumarnsit

et al.

Neuroscience Letters, Journal Year: 2025, Volume and Issue: unknown, P. 138201 - 138201

Published: March 1, 2025

Language: Английский

Citations

0
Unleashing the potential: 40 Hz multisensory stimulation therapy for cognitive impairment DOI Creative Commons

Xiao Chen,

Zhongyue Lv,

Guomin Xie

et al.

Journal of Central Nervous System Disease, Journal Year: 2025, Volume and Issue: 17

Published: March 1, 2025

Cognitive impairment encompasses a spectrum of disorders marked by acquired deficits in cognitive function, potentially leading to diminished daily functioning and work capacity, often accompanied psychiatric behavioral disturbances. Alzheimer's disease (AD) Post-stroke (PSCI) are significant causes decline. With the global population getting older, AD PSCI becoming major health concerns, underscoring critical necessity for successful treatment options. In recent years, various non-invasive biophysical stimulation techniques, including ultrasound, light, electric, magnetic stimulation, have been developed central nervous system diseases. Preliminary clinical studies demonstrated feasibility safety these techniques. This review discuss impact 40 Hz multisensory on cerebral outcomes, progression both animal models individuals exhibiting deficits, such as PSCI. Furthermore, it summarizes potential neural pathways involved this therapeutic modality synthesizing evidence from variety within field. Subsequently, evaluates existing constraints technique underscores advantages therapy with goal enhancing management care

Language: Английский

Citations

0
Gamma oscillation modulation for cognitive impairment: A systematic review DOI Creative Commons
Emanuela Bartolini, Adolfo Di Crosta, Pasquale La Malva

et al.

Journal of Alzheimer s Disease, Journal Year: 2025, Volume and Issue: unknown

Published: March 28, 2025

Background Gamma oscillation modulation has emerged as a potential non-invasive treatment to counteract cognitive impairment in Alzheimer's disease (AD) and mild (MCI). Non-invasive brain stimulation techniques like transcranial alternating current (tACS), gamma sensory (GSS), magnetic (TMS) show promise supporting specific functions. Objective To review evaluate the efficacy of benefiting functions among individuals with AD MCI. Methods A systematic was conducted, analyzing studies from 2015 2023 across databases such PubMed, Web Science, Scopus. Inclusion criteria focused on involving tACS, GSS, or TMS applied older adults MCI AD. total 438 articles were screened, which 10 met eligibility criteria. Results Findings suggest that especially targeting precuneus dorsolateral prefrontal cortex, benefits episodic memory performance. GSS also showed attention, while exhibited inconsistent but promising results when angular gyrus. However, heterogeneity study designs small sample sizes limit generalizability these outcomes. Conclusions offers for patients MCI, particularly support. Further larger samples well-designed protocols are needed confirm its therapeutic optimize intervention parameters.

Language: Английский

Citations

0
Genetic modulation of brain dynamics in neurodevelopmental disorders: the impact of copy number variations on resting-state EEG DOI Creative Commons
Adrien E. E. Dubois,

Elisabeth Audet-Duchesne,

Inga Sophia Knoth

et al.

Translational Psychiatry, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 11, 2025

Abstract Research has shown that many copy number variations (CNVs) increase the risk of neurodevelopmental disorders (e.g., autism, ADHD, schizophrenia). However, little is known about effects CNVs on brain development and function. Resting-state electroencephalography (EEG) a suitable method to study disturbances neuronal functioning in CNVs. We aimed determine whether there are resting-state EEG signatures characteristic children with pathogenic activity 109 CNV carriers (66 deletion carriers, 43 duplication carriers) aged 3 17 years was recorded for 4 minutes. To better account developmental variations, indices (power spectral density functional connectivity) were corrected normative model estimated from 256 Healthy Brain Network controls. Results showed decreased exponent aperiodic reduced alpha peak frequency carriers. Additionally, altered periodic components connectivity several bands. Deletion exhibited similar overall pattern deviations measures, although significance effect sizes relative control group varied across can be differentiated by their power gamma band low band, showing more disrupted alterations than The distinctive patterns found most prominent during adolescence. results suggest show electrophysiological compared neurotypical controls, regardless gene dosage affected genomic region. At same time, while duplications deletions share common alterations, each exhibits distinct alteration reflect dosage-specific effects.

Language: Английский

Citations

0