Buyang Huanwu decoction promotes gray and white matter remyelination by inhibiting Notch signaling activation in the astrocyte and microglia after ischemic stroke

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119440 - 119440

Published: Feb. 1, 2025

Language: Английский

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Glutamate/GABA/glutamine ratios in intact and ischemia reperfusion challenged rat brain subregions, the effect of ischemic preconditioning

Metabolic Brain Disease, Journal Year: 2025, Volume and Issue: 40(2)

Published: Feb. 7, 2025

The proper function of the brain is entirely dependent on intact neurotransmission, where glutamate (Glu) and γ-aminobutyric acid (GABA) are two most present neurotransmitters. Maintenance these neurotransmitters pools strictly relying de novo synthesis glutamine in astrocytes. Cerebral ischemic events disrupt balance uptake re-synthesis, altering Glu, GABA, (Gln) levels. We focused determining ratios glutamate, GABA rats state, early changes temporal development towards recovery after disruption by global cerebral ischemia. Animals underwent 15 min ischemia, Glu/GABA/Gln hippocampus, cortex, cerebellum were assessed at 3 h, 24 72 h post-reperfusion using high-resolution NMR. Ischemic preconditioning was also used to induce tolerance. In an rat brain, level about twice that all substructures, sevenfold compared hippocampus almost eightfold cerebellum. There three four times as much GABA. After severe Glu/Gln well GABA/Gln extensively dropped reperfusion (3 h) gradually increased time, however, only ratio recovered controls. Glu/GABA remained over control animals. observed a decrease glutathione NMR peak tissue homogenates obtained data suggest accelerated accumulation intraparenchymal which even more pronounced preconditioned animals days event. postischemic restoration did not achieve before ischemia reperfusion, could be one limiting factors complete transmission recovery. Presented may advantage when comparing homeostasis but for reserve display neurotransmitter precursor ammonia transfer buffer glutamate/GABA/glutamine cycle within substructures insult rats.

Language: Английский

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Novel HOCl-Responsive Theranostic Prodrug for the Early Diagnosis and Therapy of Ischemic Stroke

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

In this work, a hypochlorous acid (HOCl)-responsive prodrug MB-R for diagnosis and therapy of ischemic stroke (IS) was constructed using the near-infrared fluorophore methylene blue linked to riluzole by urea bond. exhibits good biocompatibility, fast response (<1 min), high selectivity toward HOCl. successfully utilized visualize HOCl levels, as well distribution in brains IS mice determine progression disease. Meanwhile, treatment with could reduce cerebral infarction volume improve motor function mice. Most importantly, be through antioxidant, anti-inflammatory, neuroprotective effects, further suggesting that potentially therapeutic agent IS. Thus, work paves way development intelligent theranostic early

Language: Английский

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Microglial pyroptosis drives neuropathic pain and targeting NLRP3 alleviates pain and neuroinflammation

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2025, Volume and Issue: 1871(4), P. 167737 - 167737

Published: Feb. 17, 2025

Language: Английский

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The Role of TREM2 in Myelin Sheath Dynamics: A Comprehensive Perspective from Physiology to Pathology

Progress in Neurobiology, Journal Year: 2025, Volume and Issue: 247, P. 102732 - 102732

Published: Feb. 26, 2025

Language: Английский

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