Aging and Disease,
Journal Year:
2024,
Volume and Issue:
unknown, P. 0 - 0
Published: Jan. 1, 2024
As
a
key
member
of
the
neurotrophin
family
in
central
nervous
system,
brain-derived
neurotrophic
factor
(BDNF)
plays
critical
role
maintenance
and
plasticity
system.
Its
innate
neuroprotective
advantage
can
also
be
shared
with
brain
when
normal
aging-dependent
processes
challenge
neural
circuits.
The
intricate
relationship
between
BDNF
resilience
during
aging
process
signifies
molecular
mechanisms
that
underlie
protection
function,
such
as
cognition,
movement
psychological
well-being.
is
crucial
for
neuronal
growth
survival,
it
promote
against
age-related
functional
decline
frailty,
even
if
fails
to
entirely
prevent
aging-related
decline.
In
present
review,
we
discuss
function
from
perspective
how
may
aging.
We
emphasize
briefly
principal,
well-known
cellular
hallmarks
restrict
disabling
dynamics
enhance
overall
Insight
into
pathways
through
which
reduces
dysfunctions
and/or
improves
resilience,
provides
foundation
developing
targeted
interventions
mental
well-being
an
population.
Brain Sciences,
Journal Year:
2024,
Volume and Issue:
14(4), P. 320 - 320
Published: March 27, 2024
Introduction:
Methamphetamine
is
a
highly
stimulating
psychoactive
drug
that
causes
life-threatening
addictions
and
affects
millions
of
people
around
the
world.
Its
effects
on
brain
are
complex
include
disturbances
in
neurotransmitter
systems
neurotoxicity.
There
several
known
treatment
methods,
but
their
effectiveness
moderate.
It
must
be
emphasised
no
drugs
have
been
approved
for
treatment.
For
this
reason,
there
an
urgent
need
to
develop
new,
effective,
safe
treatments
methamphetamine.
One
potential
mindfulness
meditation.
In
recent
years,
technique
has
researched
extensively
context
many
neurological
psychiatric
disorders.
Methods:
This
review
explores
use
methamphetamine
addiction.
Searches
were
conducted
PubMed/Medline,
Research
Gate,
Cochrane
databases.
Results:
Ten
studies
identified
used
mindfulness-based
interventions
The
results
show
effective
form
reducing
hunger,
risk
relapses,
stress
indicators,
depression,
aggression,
alone
or
combination
with
transcranial
direct
current
stimulation
(tDCS).
Mindfulness
also
improved
cognitive
function
addicts.
included
only
behavioural
measures.
mechanisms
addiction
explained,
it
was
proposed
can
induce
neuroplasticity,
alleviating
symptoms
Conclusions:
Evidence
from
suggest
may
option
addiction,
tDCS.
However,
further
high-quality
research
required
establish
role
field.
neuroimaging
neurophysiological
measures
fundamental
understand
mindfulness.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(20), P. 11306 - 11306
Published: Oct. 21, 2024
The
trigeminal
sensory
system
consists
of
the
nerve,
ganglion,
and
nuclei
(the
mesencephalic
nucleus,
principal
spinal
several
smaller
nuclei).
Various
signals
carried
by
nerve
from
orofacial
area
travel
into
system,
where
they
are
processed
integrated
information
that
is
relayed
to
higher
brain
areas.
Thus,
knowledge
essential
for
comprehending
pain.
This
review
elucidates
individual
comprise
their
synaptic
transmission.
Additionally,
it
discusses
four
types
pain
relationship
system.
Consequently,
this
aims
enhance
understanding
mechanisms
underlying
Molecular Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
22(1), P. 154 - 167
Published: Nov. 26, 2024
Inflammation
is
emerging
as
a
critical
player
in
the
disease
progression
of
Alzheimer's
(AD)
by
its
interaction
with
amyloid
beta
plaques
feed-forward
loop.
There
also
decline
nourishment
and
enriching
neurotrophic
factor,
brain-derived
factor
(BDNF),
brain.
Therefore,
supplementing
brain
BDNF
gene
delivery
delivering
anti-inflammatory
agent,
cannabidiol
(CBD)
this
case,
to
mitigate
inflammation-induced
cascade
offers
an
attractive
treatment
strategy.
To
achieve
localization
CBD
pBDNF,
lipid
nanoparticles
(LNPs)
functionalized
mannose
penetratin
were
utilized.
pBDNF
successfully
encapsulated
LNPs
(more
than
80%)
size
less
180
nm,
polydispersity
index
0.25,
zeta
potential
23
mV.
was
released
from
formulation
over
period
week.
The
dual-functionalized
demonstrated
higher
cellular
uptake
expressed
significantly
amount
(
Aging and Disease,
Journal Year:
2024,
Volume and Issue:
unknown, P. 0 - 0
Published: Jan. 1, 2024
As
a
key
member
of
the
neurotrophin
family
in
central
nervous
system,
brain-derived
neurotrophic
factor
(BDNF)
plays
critical
role
maintenance
and
plasticity
system.
Its
innate
neuroprotective
advantage
can
also
be
shared
with
brain
when
normal
aging-dependent
processes
challenge
neural
circuits.
The
intricate
relationship
between
BDNF
resilience
during
aging
process
signifies
molecular
mechanisms
that
underlie
protection
function,
such
as
cognition,
movement
psychological
well-being.
is
crucial
for
neuronal
growth
survival,
it
promote
against
age-related
functional
decline
frailty,
even
if
fails
to
entirely
prevent
aging-related
decline.
In
present
review,
we
discuss
function
from
perspective
how
may
aging.
We
emphasize
briefly
principal,
well-known
cellular
hallmarks
restrict
disabling
dynamics
enhance
overall
Insight
into
pathways
through
which
reduces
dysfunctions
and/or
improves
resilience,
provides
foundation
developing
targeted
interventions
mental
well-being
an
population.
