Medicine,
Journal Year:
2024,
Volume and Issue:
103(44), P. e40396 - e40396
Published: Nov. 1, 2024
Translocator
protein
18
kDa
(TSPO)
is
a
mitochondrial
membrane
that
involved
in
inflammation,
oxidative
stress,
and
steroidogenesis.
TSPO
may
be
marker
of
inflammatory
responses
the
brain
other
organs,
but
there
have
been
few
studies
potential
clinical
significance
measuring
circulating
concentration,
especially
patients
with
sepsis.
In
this
study,
we
compared
concentrations
sepsis
healthy
controls
to
investigate
utility
plasma
for
diagnosis
Patients
admitted
intensive
care
unit
Hiroshima
University
Hospital
between
January
2020
April
2024
were
enrolled.
Plasma
samples
collected
from
within
24
hours
admission
also
volunteers,
their
compared.
Receiver
operating
characteristic
analysis
was
used
evaluate
usefulness
concentration
We
investigated
relationships
severity
sepsis,
complications,
prognosis
patients.
Eighty
subjects
(52
28
controls)
included
study.
The
significantly
lower
than
those
(0.094
vs
0.25
ng/mL,
P
<
.001),
receiver
generated
an
area
under
curve
0.81
(95%
confidence
interval:
0.72–0.91).
not
associated
or
prognosis.
useful
biomarker
PLoS ONE,
Journal Year:
2024,
Volume and Issue:
19(5), P. e0301118 - e0301118
Published: May 16, 2024
While
the
applicability
and
popularity
of
theta
burst
stimulation
(TBS)
paradigms
remain,
current
knowledge
their
neurobiological
effects
is
still
limited,
especially
with
respect
to
impact
on
glial
cells
neuroinflammatory
processes.
We
used
a
multimodal
imaging
approach
assess
clinical
course
TBS
markers
for
microglia
activation
tissue
injury
as
an
indirect
assessment
Healthy
non-human
primates
received
continuous
(cTBS),
intermittent
(iTBS),
or
sham
over
motor
cortex
at
90%
resting
threshold.
Stimulation
was
delivered
awake
subjects
5
times
week
3-4
weeks.
Translocator
protein
(TSPO)
expression
evaluated
using
Positron
Emission
Tomography
[11C]PBR28,
myo-inositol
(mI)
N-acetyl-aspartate
(NAA)
concentrations
were
assessed
Magnetic
Resonance
Spectroscopy.
Animals
then
euthanized,
immunofluorescence
staining
performed
antibodies
against
TSPO.
Paired
t-tests
showed
no
significant
changes
in
[11C]PBR28
measurements
after
stimulation.
Similarly,
mI
NAA
found.
Post-mortem
TSPO
evaluation
comparable
mean
intensity
active
delivery.
The
study
suggests
that
healthy
brains
TBS,
in-vivo
techniques
(PET
MRS),
did
not
measurably
modulate
glia
related
metabolite
associated
neural
viability.
Neurology neuropsychiatry Psychosomatics,
Journal Year:
2024,
Volume and Issue:
16(5), P. 91 - 98
Published: Oct. 20, 2024
Gidazepam
is
a
benzodiazepine
tranquilizer
with
several
characteristic
pharmacodynamic
properties:
lower
affinity
to
GABAА-receptors
than
classical
benzodiazepines,
partial
agonism
and
modulation
of
by
stimulation
neurosteroid
synthesis
through
binding
the
TranSlocator
PrOtein
(TSPO),
influence
on
activity
serotonergic,
dopaminergic
noradrenergic
systems.
Clinically,
characterized
rapid
sustained
anxiolytic,
antiasthenic,
vegetotropic
procognitive
effects.
In
range
therapeutic
doses
(20–50
mg/day),
drug
has
antiasthenic
properties
without
subsequent
exhaustion;
effects
upper
dose
(from
100–150
mg/day)
are
closer
classic
tranquilizers.
The
well
tolerated,
it
not
sedation
muscle
relaxation,
risk
addiction
or
dependence
extremely
low.
Medicine,
Journal Year:
2024,
Volume and Issue:
103(44), P. e40396 - e40396
Published: Nov. 1, 2024
Translocator
protein
18
kDa
(TSPO)
is
a
mitochondrial
membrane
that
involved
in
inflammation,
oxidative
stress,
and
steroidogenesis.
TSPO
may
be
marker
of
inflammatory
responses
the
brain
other
organs,
but
there
have
been
few
studies
potential
clinical
significance
measuring
circulating
concentration,
especially
patients
with
sepsis.
In
this
study,
we
compared
concentrations
sepsis
healthy
controls
to
investigate
utility
plasma
for
diagnosis
Patients
admitted
intensive
care
unit
Hiroshima
University
Hospital
between
January
2020
April
2024
were
enrolled.
Plasma
samples
collected
from
within
24
hours
admission
also
volunteers,
their
compared.
Receiver
operating
characteristic
analysis
was
used
evaluate
usefulness
concentration
We
investigated
relationships
severity
sepsis,
complications,
prognosis
patients.
Eighty
subjects
(52
28
controls)
included
study.
The
significantly
lower
than
those
(0.094
vs
0.25
ng/mL,
P
<
.001),
receiver
generated
an
area
under
curve
0.81
(95%
confidence
interval:
0.72–0.91).
not
associated
or
prognosis.
useful
biomarker
