A population code for idiothetic representations in the hippocampal-septal circuit DOI Open Access
Guillaume Etter, Suzanne van der Veldt, Coralie‐Anne Mosser

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 15, 2023

The hippocampus is a higher-order brain structure responsible for encoding new episodic memories and predicting future outcomes. In absence of external stimuli, neurons in the express sequential activities which have been proposed to support path integration by tracking elapsed time, distance traveled, other idiothetic variables. On hand, with sufficient sensory inputs, hippocampal can fire respect allocentric cues. Previously, these codes described conditions where running speed clamped experimentally. To this day, balance representations freely moving remains unclear. Additionally, whether CA1 CA3 temporal are transmitted downstream lateral septum has not established. Here, we develop an unsupervised model trained compress neural information minimal loss, find that efficiently decode time travelled from low-dimensional embeddings activity mice. We also developed unbiased metrics minimally sensitive quantization parameters enable comparisons across modalities regions. more than 30,000 pyramidal neurons, show spatiotemporal represented as mixture self-motion, well information, dictated task demand environmental conditions. particular, subset encode relative rewards. Single cell population statistics hippocampal-septal circuit reveal variables emerge integrated postsynaptically septum. Finally, implement computational replicate real world activity, grid cells could provide plausible input distance. Altogether, our results suggest continuously integrates both signals depending on available cues, high-level effectively

Language: Английский

Modeling the contribution of theta-gamma coupling to sequential memory, imagination, and dreaming DOI Creative Commons
Gabriele Pirazzini, Mauro Ursino

Frontiers in Neural Circuits, Journal Year: 2024, Volume and Issue: 18

Published: June 14, 2024

Gamma oscillations nested in a theta rhythm are observed the hippocampus, where assumed to play role sequential episodic memory, i.e., memorization and retrieval of events that unfold time. In this work, we present an original neurocomputational model based on neural masses, which simulates encoding sequences hippocampus subsequent by exploiting theta-gamma code. The is three-layer structure individual Units oscillate with gamma code for features episode. first layer (working memory prefrontal cortex) maintains cue until new signal presented. second (CA3 cells) implements auto-associative excitatory inhibitory plastic synapses recover entire episode from single feature. disinhibited external source (septum or Papez circuit). third (CA1 hetero-associative net previous layer, able sequence episodes one. During phase, simulating high-acetylcholine levels, network trained Hebbian (synchronizing) anti-Hebbian (desynchronizing) rules. (low-acetylcholine), can correctly initial using inside rhythm. Moreover, high noise, isolated environment mind-wandering condition, randomly replicating sequences. Interestingly, state sleep, increased noise reduced synapses, “dream” creatively combining sequences, shared different episodes. Finally, irrational behavior (erroneous superimposition various episodes, like “delusion”) occurs after pathological-like reduction fast synapses. represent straightforward innovative tool help mechanistically understand mental states.

Language: Английский

Citations

1
Idiothetic representations are modulated by availability of sensory inputs and task demands in the hippocampal-septal circuit DOI Creative Commons
Guillaume Etter, Suzanne van der Veldt, Coralie‐Anne Mosser

et al.

Cell Reports, Journal Year: 2024, Volume and Issue: 43(11), P. 114980 - 114980

Published: Nov. 1, 2024

The hippocampus is a higher-order brain structure responsible for encoding new episodic memories and predicting future outcomes. In the absence of external stimuli, neurons in track elapsed time, distance traveled, other idiothetic variables. To this day, exact determinants representations during free navigation remain unclear. Here, we developed unsupervised approaches to extract population single-cell properties more than 30,000 CA1 pyramidal freely moving mice. We find that spatiotemporal are composed mixture allocentric information, balance which dictated by task demand environmental conditions. Additionally, subset encodes rewards. Finally, time information integrated postsynaptically lateral septum, indicating these high-level effectively downstream neurons.

Language: Английский

Citations

1
Effect of aerobic intermittent exercise on the decreased cognitive ability induced by PM2.5 exposure in rats DOI Creative Commons
Zhongwei Wang, Fei Qin, Dongzhe Wu

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: 1(2), P. 170 - 181

Published: July 1, 2024

Abstract Objectives This study aimed to investigate the protective effects and underlying mechanisms of aerobic intermittent exercise on cognitive impairment by PM 2.5 exposure. Methods Thirty-two rats were randomly divided into four groups: sedentary, exercise, sedentary + exposure, The groups underwent 8 weeks training (5 days per week). Subsequently, exposure subjected for three weeks. Post-exposure, we assessed abilities (shuttle box test), hippocampal tissue structure, related inflammatory factors (TNF-α, IL-6, IL-1β), protein responses mechanism (P65, IκκB) cognitive-related levels (BDNF, Aβ-42). Results caused impairment, abnormal histopathological changes, reduced increased pro-inflammatory cytokine levels. Analysis shuttle test data revealed significant main passive avoidance latency times measured in (p<0.05). Aerobic improves spatial learning decline induced . Conversely, Exercise group demonstrated a reduction 24.9 % compared Sedentary (p<0.05, ES=1.41). Conclustion may help protecting against decrease ability

Language: Английский

Citations

0
A population code for idiothetic representations in the hippocampal-septal circuit DOI Open Access
Guillaume Etter, Suzanne van der Veldt, Coralie‐Anne Mosser

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 15, 2023

The hippocampus is a higher-order brain structure responsible for encoding new episodic memories and predicting future outcomes. In absence of external stimuli, neurons in the express sequential activities which have been proposed to support path integration by tracking elapsed time, distance traveled, other idiothetic variables. On hand, with sufficient sensory inputs, hippocampal can fire respect allocentric cues. Previously, these codes described conditions where running speed clamped experimentally. To this day, balance representations freely moving remains unclear. Additionally, whether CA1 CA3 temporal are transmitted downstream lateral septum has not established. Here, we develop an unsupervised model trained compress neural information minimal loss, find that efficiently decode time travelled from low-dimensional embeddings activity mice. We also developed unbiased metrics minimally sensitive quantization parameters enable comparisons across modalities regions. more than 30,000 pyramidal neurons, show spatiotemporal represented as mixture self-motion, well information, dictated task demand environmental conditions. particular, subset encode relative rewards. Single cell population statistics hippocampal-septal circuit reveal variables emerge integrated postsynaptically septum. Finally, implement computational replicate real world activity, grid cells could provide plausible input distance. Altogether, our results suggest continuously integrates both signals depending on available cues, high-level effectively

Language: Английский

Citations

1