Extracellular vesicles as precision therapeutics for psychiatric conditions: targeting interactions among neuronal, glial, and immune networks DOI Creative Commons
Ivana Kawiková, Václav Špička,

James C. K. Lai

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 8, 2025

The critical role of the immune system in brain function and dysfunction is well recognized, yet development therapies for psychiatric diseases has been slow due to concerns about iatrogenic deficiencies. These are emphasized by lack objective diagnostic tools psychiatry. A promise resolve this conundrum lies exploitation extracellular vesicles (EVs) that physiologically produced or can be synthetized. EVs regulate recipient cell functions offer potential EVs-based therapies. Intranasal administration enables targeting specific regions functions, thereby facilitating design precise treatments diseases. such requires navigating four dynamically interacting networks: neuronal, glial, immune, EVs. networks profoundly influenced fluid distribution. They crucial homeostasis, cellular intercellular communication. Fluid abnormalities, like edema altered cerebrospinal (CSF) dynamics, disrupt these networks, negatively impacting health. deeper understanding above-mentioned vital creating biomarker panels identify distinct patient subsets with similar neuro-behavioral symptoms. Testing functional pathways biomarkers could lead new therapeutic tools. Regulatory approval will depend on robust preclinical data reflecting progress interdisciplinary areas, which pave way innovative treatments. Highly collaborative teams needed achieve ambitious goals.

Language: Английский

Multiciliated ependymal cells: an update on biology and pathology in the adult brain DOI
Adam M.R. Groh,

Yeji Lori Song,

Fiona Tea

et al.

Acta Neuropathologica, Journal Year: 2024, Volume and Issue: 148(1)

Published: Sept. 10, 2024

Language: Английский

Citations

8
Research priorities for non-invasive therapies to improve hydrocephalus outcomes DOI Creative Commons
Alexandra Hochstetler, Christine Hehnly,

W. R. Dawes

et al.

Fluids and Barriers of the CNS, Journal Year: 2025, Volume and Issue: 22(1)

Published: March 3, 2025

The Hydrocephalus Association organized two workshops with the support of Rudi Schulte Research Institute and Cincinnati Children's Hospital Medical Center entitled "Developing Non-Invasive Therapies: Molecular Cellular Targets", held September 27–29, 2023, in Dallas, TX, Advancing Towards Clinical Trials", April 12–13, 2024, Cincinnati, OH. goal these was to explore frontiers ongoing research for non-invasive therapies treatment hydrocephalus across all etiologies improve patient outcomes at stages diagnosis management. During consensus-building discussions throughout workshops, basic, translational, clinical scientists aimed identify next steps develop novel treatments hydrocephalus. This detailed report discusses priorities that emerged from inspire researchers guide studies towards better people living

Language: Английский

Citations

0
Extracellular vesicles as precision therapeutics for psychiatric conditions: targeting interactions among neuronal, glial, and immune networks DOI Creative Commons
Ivana Kawiková, Václav Špička,

James C. K. Lai

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 8, 2025

The critical role of the immune system in brain function and dysfunction is well recognized, yet development therapies for psychiatric diseases has been slow due to concerns about iatrogenic deficiencies. These are emphasized by lack objective diagnostic tools psychiatry. A promise resolve this conundrum lies exploitation extracellular vesicles (EVs) that physiologically produced or can be synthetized. EVs regulate recipient cell functions offer potential EVs-based therapies. Intranasal administration enables targeting specific regions functions, thereby facilitating design precise treatments diseases. such requires navigating four dynamically interacting networks: neuronal, glial, immune, EVs. networks profoundly influenced fluid distribution. They crucial homeostasis, cellular intercellular communication. Fluid abnormalities, like edema altered cerebrospinal (CSF) dynamics, disrupt these networks, negatively impacting health. deeper understanding above-mentioned vital creating biomarker panels identify distinct patient subsets with similar neuro-behavioral symptoms. Testing functional pathways biomarkers could lead new therapeutic tools. Regulatory approval will depend on robust preclinical data reflecting progress interdisciplinary areas, which pave way innovative treatments. Highly collaborative teams needed achieve ambitious goals.

Language: Английский

Citations

0