CDR1as Deficiency Prevents Photoreceptor Degeneration by Regulating miR-7a-5p/α-syn/Parthanatos Pathway in Retinal Detachment DOI

Feiyu Jin,

Yuanye Yan,

Ziyang Ye

et al.

American Journal Of Pathology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

The molecular mechanism of ferroptosis and its relationship with Parkinson's disease DOI Creative Commons

Yan Su,

Yue Jiao,

Sheng Cai

et al.

Brain Research Bulletin, Journal Year: 2024, Volume and Issue: 213, P. 110991 - 110991

Published: May 31, 2024

Neurodegenerative diseases such as Parkinson's disease (PD) have complex pathogenetic mechanisms. Genetic, age, and environmental factors are all related to PD. Due the unclear pathogenesis of PD lack effective cure methods, it is urgent find new targets for treating patients. Ferroptosis a form cell death that reliant on iron exhibits distinct morphological mechanistic characteristics compared other types death. It encompasses range biological processes, including iron/lipid metabolism oxidative stress. In recent years, research has found ferroptosis plays crucial role in pathophysiological processes neurodegenerative stroke. Therefore, also closely PD, This article reviews core mechanisms elucidates correlation between ferroptosis. addition, compounds emerged years exert anti effects by inhibiting signaling pathway were summarized. I hope further elaborate relationship through review this article, provide strategies developing treatments targeting

Language: Английский

Citations

7
Opioid and Cannabinoid Systems in Pain: Emerging Molecular Mechanisms and Use in Clinical Practice, Health, and Fitness DOI Open Access
Carmine Secondulfo, Filomena Mazzeo, Grazia Maria Giovanna Pastorino

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9407 - 9407

Published: Aug. 29, 2024

Pain is an unpleasant sensory and emotional experience. Adequate pain control often challenging, particularly in patients with chronic pain. Despite advances management, drug addiction, overtreatment, or substance use disorders are not rare. Hence the need for further studies field. The substantial progress made over last decade has revealed genes, signalling pathways, molecules, neuronal networks thus opening new clinical perspectives management. In this respect, data on epigenetic modulation of opioid cannabinoid receptors, key actors pain, offered to preserve activity endocannabinoid systems increase analgesic efficacy opioid- cannabinoid-based drugs. Similarly, upcoming cannabidiol (CBD), a non-psychoactive marijuana plant Cannabis sativa, suggests analgesic, anti-inflammatory, antioxidant, anticonvulsivant ansiolitic effects supports its potential application contexts such as cancer, neurodegeneration, autoimmune diseases but also health fitness athletes. Hence, review article, we summarize emerging modifications receptors focus CBD management practice, health, fitness.

Language: Английский

Citations

4
Identification of mitophagy-related genes and analysis of immune infiltration in the astrocytes based on machine learning in the pathogenesis of major depressive disorder DOI
Lan Lei,

Cong-Ya Chen,

Yufei Wang

et al.

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

Citations

4
Values of epigenetic markers in Parkinson's disease as biomarkers and therapeutic targets: A narrative review DOI Creative Commons
Dhruv Parikh, Manan Shah

NeuroMarkers., Journal Year: 2025, Volume and Issue: unknown, P. 100037 - 100037

Published: Feb. 1, 2025

Language: Английский

Citations

0
Non-Coding RNAs in Parkinson's Disease: Regulating SNCA and Alpha-Synuclein Aggregation DOI
Lakshmi Thangavelu, Ehssan Moglad, Muhammad Afzal

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 261, P. 155511 - 155511

Published: July 30, 2024

Language: Английский

Citations

2
The mechanistic view of non-coding RNAs as a regulator of inflammatory pathogenesis of Parkinson’s disease DOI
Yuan Li, Chunlei Yu, Xiaobing Jiang

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 258, P. 155349 - 155349

Published: May 16, 2024

Language: Английский

Citations

1
Neuroinflammation in Parkinson’s disease: focus on the relationship between miRNAs and microglia DOI Creative Commons
Ke Xu, Li Yan Yuan, Yan Zhou

et al.

Frontiers in Cellular Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: July 26, 2024

Parkinson’s disease (PD) is a prevalent neurodegenerative disorder that affects the central nervous system (CNS). Neuroinflammation crucial factor in pathological advancement of PD. PD characterized by presence activated microglia and increased levels proinflammatory factors, which play role its pathology. During immune response PD, regulation significantly influenced microRNA (miRNA). The excessive activation microglia, persistent neuroinflammation, abnormal polarization macrophages brain can be attributed to dysregulation certain miRNAs. Additionally, there are miRNAs possess ability inhibit neuroinflammation. miRNAs, small non-coding epigenetic regulators, have modulate microglial activity both normal conditions. They also significant impact on promoting communication between neurons microglia.

Language: Английский

Citations

1
CDR1as Deficiency Prevents Photoreceptor Degeneration by Regulating miR-7a-5p/α-syn/Parthanatos Pathway in Retinal Detachment DOI

Feiyu Jin,

Yuanye Yan,

Ziyang Ye

et al.

American Journal Of Pathology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

Citations

0