Automated optical system of integrated photostimulation of the human nervous system DOI

Gregory S. Tymchyk,

Volodymyr Skytsiouk,

Tatiana Klotchko

et al.

Photonics Applications in Astronomy, Communications, Industry, and High-Energy Physics Experiments 2019, Journal Year: 2024, Volume and Issue: unknown, P. 8 - 8

Published: Dec. 16, 2024

This article illustrates the method and optical system of integrated photostimulation human nervous system, which forms therapeutic effect electromagnetic fields through eye system. In this work are consider directions application stimulation structures due to formation influence by flows with different radiation frequencies. A detailed description operation proposed provides opportunities for creation new hardware techniques.

Language: Английский

Photovoltaic bioelectronics merging biology with new generation semiconductors and light in biophotovoltaics photobiomodulation and biosensing DOI Creative Commons
Ebin Joseph, Manuela Ciocca, Haodong Wu

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: 1(1)

Published: Nov. 21, 2024

Abstract This review covers advancements in biosensing, biophotovoltaics, and photobiomodulation, focusing on the synergistic use of light, biomaterials, cells or tissues, interfaced with photosensitive dye-sensitized, perovskite, conjugated polymer organic semiconductors nanoparticles. Integration semiconductor biological systems, using non-invasive light-probes -stimuli for both sensing controlling behavior, has led to groundbreaking applications like artificial retinas. From fusion photovoltaics biology, a new research field emerges: photovoltaic bioelectronics.

Language: Английский

Citations

5
Gold Nanorod-Coated Hydrogel Brush Valves in Macroporous Silicon Membranes for NIR-Driven Localized Chemical Modulation DOI Creative Commons

Nafis Mustakim,

Youngsik Song,

Sang‐Woo Seo

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(1), P. 25 - 25

Published: Jan. 1, 2025

A two-dimensional array of microfluidic ports with remote-controlled valve actuation is great interest for applications involving localized chemical stimulation. Herein, a macroporous silicon-based platform where each pore contains an independently controllable made from poly(N-isopropylacrylamide) (PNIPAM) brushes proposed. These valves are coated silica-encapsulated gold nanorods (GNRs) NIR-actuated switching capability. The layer-by-layer (LBL) electrostatic deposition technique was used to attach the GNRs PNIPAM brushes. confirmed by dark-field optical microscopy, and surface plasmon resonance (LSPR) deposited analyzed using UV-Vis spectra. To evaluate release behaviors, fluorescein dye employed as model substance. properties, like OFF-state diffusion through valve, ratio between ON-state release, rapidness modulation were investigated, varying brush thickness. results indicate that enhancing thickness in our improves control over properties. However, excessive increases length may lead entanglement, which negatively impacts efficiency.

Language: Английский

Citations

0
Intravitreally Injected Plasmonic Nanorods Activate Bipolar Cells with Patterned Near-Infrared Laser Projection DOI
Jiarui Nie, Kyungsik Eom,

Hafithe M. AlGhosain

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Retinal prostheses aim to restore vision in individuals affected by degenerative conditions, such as age-related macular degeneration and retinitis pigmentosa. Traditional approaches, including implantable electrode arrays optogenetics, often require invasive surgery or genetic modification face limitations spatial resolution visual field size. While emerging nanoparticle-based methods offer minimally solutions, some of them rely on intense visible light, which may interfere with residual vision. Plasmonic gold nanorods (AuNRs), tuned absorb near-infrared (NIR) provide a promising alternative enabling photothermal neuromodulation without affecting the remaining sight. However, effectively utilizing stimulation patterned laser projection for precise neural activation remains underexplored. In this study, we introduce less approach using intravitreally injected anti-Thy1 antibody-conjugated AuNRs primarily activate bipolar cells─a target traditionally reached through more subretinal injections. This technique allows extensive retinal coverage facilitates high-resolution restoration via NIR stimulation. Following injection, scanning beam projected square pattern spot size 20 μm consistently triggered highly localized neuronal activation, specifically stimulating cells temperature-sensitive ion channels. vivo, evoked electrocorticogram responses cortex both wild-type fully blind mouse models inducing systemic toxicity significant damage. Our innovative promises advancements broad applicability, offering precise, customizable, method

Language: Английский

Citations

0
Automated optical system of integrated photostimulation of the human nervous system DOI

Gregory S. Tymchyk,

Volodymyr Skytsiouk,

Tatiana Klotchko

et al.

Photonics Applications in Astronomy, Communications, Industry, and High-Energy Physics Experiments 2019, Journal Year: 2024, Volume and Issue: unknown, P. 8 - 8

Published: Dec. 16, 2024

This article illustrates the method and optical system of integrated photostimulation human nervous system, which forms therapeutic effect electromagnetic fields through eye system. In this work are consider directions application stimulation structures due to formation influence by flows with different radiation frequencies. A detailed description operation proposed provides opportunities for creation new hardware techniques.

Language: Английский

Citations

0