Treatment of severe traumatic brain injury with human bone marrow mesenchymal stem cell extracellular vesicles: a case report

Brain Injury, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 6

Published: Jan. 1, 2025

Objective Extracellular vesicles (EVs) derived from regenerative mesenchymal stem cells might safely treat traumatic brain injury (TBI). We evaluated the safety and efficacy of a human bone marrow cell EVs (hBM-MSC EV) investigational product (IP) in patient with severe TBI.

Language: Английский

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Blood-brain barrier repair: potential and challenges of stem cells and exosomes in stroke treatment

Frontiers in Cellular Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: April 7, 2025

Stroke is characterized with high morbidity, mortality and disability all over the world, one of its core pathologies blood-brain barrier (BBB) dysfunction. BBB plays a crucial physiological role in protecting brain tissues maintaining homeostasis central nervous system (CNS). dysfunction serves as key factor development cerebral edema, inflammation, further neurological damage stroke patients. Currently, stem cells their derived exosomes have shown remarkable potential repairing damaged improving function after stroke. Stem repair integrity through anti-inflammatory, antioxidant, angiogenesis regulation intercellular signaling mechanisms, while cell-derived exosomes, natural nanocarriers, enhance therapeutic effect by carrying active substances such proteins, RNAs miRNAs. This review will present latest research advances treatment, well challenges cell source, transplantation timing, dosage, route administration clinical application, aiming to discuss mechanisms for proposes future directions. are expected provide new strategies early diagnosis precise treatment stroke, promote breakthroughs field

Language: Английский

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Mesenchymal stem cell exosomes therapy for the treatment of traumatic brain injury: mechanism, progress, challenges and prospects

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 11, 2025

Language: Английский

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Ginsenoside Rd and chrysophanol: Modulating the serine-glycine-one-carbon pathway to enhance neuroprotection in intracerebral hemorrhage

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 160, P. 108493 - 108493

Published: April 19, 2025

Language: Английский

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Exosomes and tissue engineering: A novel therapeutic strategy for nerve regenerative

Tissue and Cell, Journal Year: 2024, Volume and Issue: 93, P. 102676 - 102676

Published: Dec. 13, 2024

Language: Английский

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