Enhancing mPFC to BLA information transmission through chemical genetics to improve exploratory behavior in chronic stress rats DOI Creative Commons
Jin Guo,

Qingying Cao,

Huicong Jie

et al.

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: 225, P. 111335 - 111335

Published: April 8, 2025

The pathogenesis of depression is fundamentally linked to the dysregulation neural circuit structure and function. Notably, medial prefrontal cortex (mPFC) basolateral amygdala (BLA) are critical brain regions in regulation depression-related behaviors. Depressed rats exhibited attenuated messaging between mPFC BLA, along with abnormally enhanced theta oscillations BLA during execution an exploratory task. However, whether specific activation improves behavior recovery mediated by mPFC-BLA circuitry unknown. We modeled using chronic unpredictable mild stimulation (CUMS) employed chemogenetic approaches selectively activate glutamatergic neurons depressed rats. Through simultaneous monitoring behavioral patterns local field potentials (LFPs) both open-field exploration, we conducted comparative analyses chemogenetically activated sham-stimulated groups. Our investigation focused on oscillation dynamics, network connectivity strength, interregional information transfer behavior. results demonstrated that not only ameliorated deficits but also mPFC-to-BLA while attenuating oscillations. These findings suggest restoration flow may play a crucial role improving behavior, thereby revealing potential mechanism underlying depressive state modulation.

Language: Английский

The role of neuroinflammation in PV interneuron impairments in brain networks; implications for cognitive disorders DOI

Pantea Allami,

Niloufar Yazdanpanah,

Nima Rezaei

et al.

Reviews in the Neurosciences, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Abstract Fast spiking parvalbumin (PV) interneuron is an inhibitory gamma-aminobutyric acid (GABA)ergic diffused in different brain networks, including the cortex and hippocampus. As a key component of PV interneurons collaborate fundamental functions such as learning memory by regulating excitation inhibition (E/I) balance generating gamma oscillations. The unique characteristics interneurons, like their high metabolic demands long branching axons, make them too vulnerable to stressors. Neuroinflammation one most significant stressors that have adverse, long-lasting impact on interneurons. affects through specialized inflammatory pathways triggered cytokines tumor necrosis factor (TNF) interleukin 6 (IL-6). crucial cells neuroinflammation, microglia, also play role. destructive effect inflammation can comprehensive effects cause neurological disorders schizophrenia, Alzheimer’s disease (AD), autism spectrum disorder (ASD), bipolar disorder. In this article, we provide review mechanisms which neuroinflammation leads hypofunction these diseases. integrated knowledge about role cognitive networks involved impairment pathology diseases help us with better therapeutic interventions.

Language: Английский

Citations

1
Effects of anxiety induced by conditioned fear on the expression of NMDA receptors and synaptic plasticity in the rat BLA DOI

Yue-Heng Yan,

Hongkun Wang, Zihao Wang

et al.

Behavioural Brain Research, Journal Year: 2025, Volume and Issue: unknown, P. 115547 - 115547

Published: March 1, 2025

Language: Английский

Citations

0
Enhancing mPFC to BLA information transmission through chemical genetics to improve exploratory behavior in chronic stress rats DOI Creative Commons
Jin Guo,

Qingying Cao,

Huicong Jie

et al.

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: 225, P. 111335 - 111335

Published: April 8, 2025

The pathogenesis of depression is fundamentally linked to the dysregulation neural circuit structure and function. Notably, medial prefrontal cortex (mPFC) basolateral amygdala (BLA) are critical brain regions in regulation depression-related behaviors. Depressed rats exhibited attenuated messaging between mPFC BLA, along with abnormally enhanced theta oscillations BLA during execution an exploratory task. However, whether specific activation improves behavior recovery mediated by mPFC-BLA circuitry unknown. We modeled using chronic unpredictable mild stimulation (CUMS) employed chemogenetic approaches selectively activate glutamatergic neurons depressed rats. Through simultaneous monitoring behavioral patterns local field potentials (LFPs) both open-field exploration, we conducted comparative analyses chemogenetically activated sham-stimulated groups. Our investigation focused on oscillation dynamics, network connectivity strength, interregional information transfer behavior. results demonstrated that not only ameliorated deficits but also mPFC-to-BLA while attenuating oscillations. These findings suggest restoration flow may play a crucial role improving behavior, thereby revealing potential mechanism underlying depressive state modulation.

Language: Английский

Citations

0