Molecular Motors in Blood–Brain Barrier Maintenance by Astrocytes

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(3), P. 279 - 279

Published: March 6, 2025

The blood–brain barrier (BBB) comprises distinct cell types, including endothelial cells, pericytes, and astrocytes, is essential for central nervous system (CNS) homeostasis by selectively regulating molecular transport maintaining integrity. In particular, astrocytes are BBB function, as they maintain integrity through their end-feet, which form a physical biochemical interface that enhances function selectivity. Moreover, secrete growth factors like vascular factor (VEGF) transforming factor-beta (TGF-β), regulate tight junction (TJ) proteins (e.g., claudins occludins) crucial limiting paracellular permeability. Molecular motors kinesins, dynein, myosins these astrocyte functions. By facilitating vesicular trafficking protein transport, various functions, of junctional to support integrity, the proper mitochondria localization within processes efficient energy supply, polarized distribution aquaporin (AQP)-4 at end-feet water across BBB, modulation neuroinflammatory responses. myosin modulate actomyosin dynamics process outgrowth, adhesion, migration, morphology, functional roles. Thus, motor dysregulation in can compromise increasing risk neurodegeneration. This review explores complex interplay between homeostasis, represents an attractive but poorly explored area research.

Language: Английский

Unravelling the Proteinopathic Engagement of α-Synuclein, Tau, and Amyloid Beta in Parkinson’s Disease: Mitochondrial Collapse as a Pivotal Driver of Neurodegeneration

Neurochemical Research, Journal Year: 2025, Volume and Issue: 50(3)

Published: April 16, 2025

Language: Английский