Stress-Induced Sleep Dysregulation: The Roles of Astrocytes and Microglia in Neurodegenerative and Psychiatric Disorders DOI Creative Commons

Ángel R. Rábago-Monzón,

Juan Fidel Osuna‐Ramos,

David A. Armienta-Rojas

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(5), P. 1121 - 1121

Published: May 6, 2025

Stress and sleep share a reciprocal relationship, where chronic stress often leads to disturbances that worsen neurodegenerative psychiatric conditions. Non-neuronal cells, particularly astrocytes microglia, play critical roles in the brain’s response regulation of sleep. Astrocytes influence architecture by regulating adenosine signaling glymphatic clearance, both which can be disrupted stress, leading reduced restorative Microglia, activated under conditions, drive neuroinflammatory processes further impair exacerbate brain dysfunction. Additionally, gut–brain axis mediates interactions between sleep, inflammation, with microbial metabolites influencing neural pathways. Many these effects converge on disruption synaptic processes, such as neurotransmitter balance, plasticity, pruning, turn contribute pathophysiology disorders. This review explores how cellular systemic mechanisms stress-induced their implications for disorders, offering insights into potential therapeutic strategies targeting non-neuronal cells axis.

Language: Английский

Neuropathogenesis of Encephalitic Alphaviruses in Non-Human Primate and Mouse Models of Infection DOI Creative Commons
Caitlin W. Lehman,

Shannon K. Carney,

Kylene Kehn‐Hall

et al.

Pathogens, Journal Year: 2025, Volume and Issue: 14(2), P. 193 - 193

Published: Feb. 14, 2025

Encephalitic alphaviruses, including eastern, Venezuelan, and western equine encephalitis virus (EEEV, VEEV, WEEV, respectively) are New World alphaviruses primarily transmitted by mosquitos that cause debilitating lethal central nervous system (CNS) disease in both humans horses. Despite over one hundred years of research on these viruses, the underpinnings molecular mechanisms driving virally induced damage to CNS remain unresolved. Moreover, following exposure viruses causes catastrophic CNS, survivors infection often suffer from permanent neurological sequelae as a result sustained neuroinflammation insults encountered. Animal models undoubtedly invaluable tools biomedical research, where physiologically relevant required study pathogenesis host-pathogen interactions. Here, we review literature examine nonhuman primate (NHP) mouse for EEEV, WEEV. We provide brief overview background information each virus, geography, epidemiology, clinical disease. The primary focus this is describe neuropathological features associated with NHP compare invasion neuropathogenesis aerosol, intranasal, subcutaneous routes

Language: Английский

Citations

0
rTMS ameliorates CUMS-induced anxiety-depression-like behaviour and cognitive dysfunction in rats by modulating the COX-2/PGE2 signalling pathway DOI

Yanjiao Pei,

Huanhuan Liu,

Jiqing Lang

et al.

Journal of Psychiatric Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Mental Health Disorders Following Exposure to Endocrine Disruptor Chemicals DOI Open Access
Mojtaba Ehsanifar,

Akram Gholami,

Alireza Esmaeili

et al.

OBM Neurobiology, Journal Year: 2025, Volume and Issue: 09(02), P. 1 - 16

Published: April 18, 2025

There is growing scientific concern regarding how endocrine-disrupting chemicals (EDCs) impact central nervous system (CNS) disorders. Both anecdotal and preclinical studies suggest a link between EDC exposure major depressive disorder (MDD), potentially leading to neurodegenerative outcomes. EDCs primarily exhibit their biological effects by interacting with hormone receptors. Nonetheless, there evidence pointing dysfunction in the hypothalamic-pituitary-gonadal-adrenal axis, which linked neuropsychiatric conditions. Additionally, global incidence of MDD has risen. Various factors like gender, genetic components, age, hormonal balance, cultural influences may explain differences prevalence. Recently, environmental pollutants such as industrial chemicals, emollients, plastics, fungicides, pesticides have emerged critical influencing this disorder. This review delves into influence key phthalate bisphenol compounds on chronic inflammation MDD.

Language: Английский

Citations

0
Multi-omics reveal the role of nociception-related genes TNXB, CTNND1 and CBL in depression DOI
Qian Wu, Dehui Lin,

Taishun Wang

et al.

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: 382, P. 346 - 354

Published: April 24, 2025

Language: Английский

Citations

0
Monoamine signaling and neuroinflammation: mechanistic connections and implications for neuropsychiatric disorders DOI Creative Commons
Shalini Saggu, Andrew Pless,

Emily Dew

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 28, 2025

Monoamines, including norepinephrine, serotonin, and dopamine, orchestrate a broad spectrum of neurophysiological homeostatic events. Recent research shows pivotal role for monoaminergic signaling in modulating neuroinflammation by regulating proinflammatory cytokines chemokines within the central nervous system. Importantly, this modulation is not unidirectional; released markedly "feedback" to influence metabolism monoamine neurotransmitters, impacting their synthesis, release, reuptake. This bidirectional interplay significantly links pathways neuroinflammatory responses. In review, we summarize current knowledge dynamic interactions between neuroinflammation, as well critical implications pathophysiology neuropsychiatric disorders, Parkinson's Disease, Major Depressive Disorder, Alzheimer's Disease. By integrating recent findings, shed light on potential therapeutic targets these interconnected pathways, providing insights into novel treatment strategies devastating disorders.

Language: Английский

Citations

0
Stress-Induced Sleep Dysregulation: The Roles of Astrocytes and Microglia in Neurodegenerative and Psychiatric Disorders DOI Creative Commons

Ángel R. Rábago-Monzón,

Juan Fidel Osuna‐Ramos,

David A. Armienta-Rojas

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(5), P. 1121 - 1121

Published: May 6, 2025

Stress and sleep share a reciprocal relationship, where chronic stress often leads to disturbances that worsen neurodegenerative psychiatric conditions. Non-neuronal cells, particularly astrocytes microglia, play critical roles in the brain’s response regulation of sleep. Astrocytes influence architecture by regulating adenosine signaling glymphatic clearance, both which can be disrupted stress, leading reduced restorative Microglia, activated under conditions, drive neuroinflammatory processes further impair exacerbate brain dysfunction. Additionally, gut–brain axis mediates interactions between sleep, inflammation, with microbial metabolites influencing neural pathways. Many these effects converge on disruption synaptic processes, such as neurotransmitter balance, plasticity, pruning, turn contribute pathophysiology disorders. This review explores how cellular systemic mechanisms stress-induced their implications for disorders, offering insights into potential therapeutic strategies targeting non-neuronal cells axis.

Language: Английский

Citations

0