Both electrical and metabolic coupling shape the collective multimodal activity and functional connectivity patterns in beta cell collectives: A computational model perspective

Physical review. E, Journal Year: 2023, Volume and Issue: 108(5)

Published: Nov. 22, 2023

Pancreatic beta cells are coupled excitable oscillators that synchronize their activity via different communication pathways. Their oscillatory manifests itself on multiple timescales and consists of bursting electrical activity, subsequent oscillations in the intracellular ${\mathrm{Ca}}^{2+}$, as well metabolism exocytosis. The coordination intricate multicellular level plays a key role regulation physiological pulsatile insulin secretion is incompletely understood. In this paper, we investigate theoretically principles give rise to synchronized cell populations by building up phenomenological model incorporates basic features dynamics. Specifically, composed slow fast units reflect metabolic processes respectively. Using realistic description intercellular interactions, study how combination coupling generates collective rhythmicity shapes functional networks. It turns out while solely can responses, addition interactions further enhances coordination, spatial range increases number connections networks, ensures better consistency with experimental findings. Moreover, our computational results provide additional insights into relationship between heterogeneity, profiles, connectivity, supplementing thereby recent endocrine

Language: Английский

Phase synchronisation in coupled oscillator chains with endpoint heterogeneity

Physica D Nonlinear Phenomena, Journal Year: 2025, Volume and Issue: unknown, P. 134610 - 134610

Published: March 1, 2025

Language: Английский

Neuron configuration enhances the synchronization dynamics in ring networks with heterogeneous firing patterns

Chaos Solitons & Fractals, Journal Year: 2024, Volume and Issue: 187, P. 115461 - 115461

Published: Sept. 4, 2024

Language: Английский