Data-driven and equation-free methods for neurological disorders: analysis and control of the striatum network DOI Creative Commons
Konstantinos Spiliotis, Rüdiger Köhling, Wolfram Just

et al.

Frontiers in Network Physiology, Journal Year: 2024, Volume and Issue: 4

Published: Aug. 7, 2024

The striatum as part of the basal ganglia is central to both motor, and cognitive functions. Here, we propose a large-scale biophysical network for this brain, using modified Hodgkin-Huxley dynamics model neurons, connectivity informed by detailed human atlas. shows different spatio-temporal activity patterns corresponding lower (presumably normal) increased cortico-striatal activation (as found in, e.g., obsessive-compulsive disorder), depending on intensity cortical inputs. By applying equation-free methods, are able perform macroscopic analysis directly from microscale simulations. We identify mean synaptic variable system, which similarity with local field potentials. approach results in numerical bifurcation stability striatal network. states can be assigned normal/healthy pathological conditions, known neurological disorders. Finally, guided analysis, therapeutic close loop control scheme

Language: Английский

Data-driven and equation-free methods for neurological disorders: analysis and control of the striatum network DOI Creative Commons
Konstantinos Spiliotis, Rüdiger Köhling, Wolfram Just

et al.

Frontiers in Network Physiology, Journal Year: 2024, Volume and Issue: 4

Published: Aug. 7, 2024

The striatum as part of the basal ganglia is central to both motor, and cognitive functions. Here, we propose a large-scale biophysical network for this brain, using modified Hodgkin-Huxley dynamics model neurons, connectivity informed by detailed human atlas. shows different spatio-temporal activity patterns corresponding lower (presumably normal) increased cortico-striatal activation (as found in, e.g., obsessive-compulsive disorder), depending on intensity cortical inputs. By applying equation-free methods, are able perform macroscopic analysis directly from microscale simulations. We identify mean synaptic variable system, which similarity with local field potentials. approach results in numerical bifurcation stability striatal network. states can be assigned normal/healthy pathological conditions, known neurological disorders. Finally, guided analysis, therapeutic close loop control scheme

Language: Английский

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