Identifying the epileptic network by linking interictal functional and structural connectivity

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 17, 2025

Over the last two decades, it has become increasingly clear that epilepsy is a network disorder. However, unclear whether these networks are established only during seizures or persist interictally. The goal of this study was to identify functional seizure exist interictally and evaluate if there structural basis networks. We identified four patients with mesial temporal lobe who underwent resective surgery. estimated connectivity across intracranial electrode contacts involved in onset, early spread, uninvolved controls. Across all interictal epochs considered, we found higher white matter cortical regions spread. Additionally, observed patient our cohort best outcome had highest contacts. Functional findings suggest presence an parallels underlying connectivity. Furthermore, disruption ablation highly connected may be necessary achieve improved post-operative freedom.

Language: Английский

Stopping runaway seizures with a chill pill

eLife, Journal Year: 2024, Volume and Issue: 13

Published: Sept. 5, 2024

The neuropeptide neurotensin can reduce status epilepticus and its associated consequences through induction of therapeutic hypothermia when bound to a molecule that penetrate the blood-brain barrier.

Language: Английский