Glia,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 3, 2024
Ceramide
C16
is
a
sphingolipid
detected
at
high
levels
in
several
neurodegenerative
disorders,
including
multiple
sclerosis
(MS).
It
can
be
generated
de
novo
or
from
the
hydrolysis
of
other
sphingolipids,
such
as
sphingomyelin
through
recycling
sphingosine,
what
known
salvage
pathway.
While
myelin
damage
occurring
MS
suggests
importance
hydrolytic
and
pathways,
growing
interest
on
diet
demyelinating
prompted
us
to
investigate
involvement
ceramide
synthesis
disease
severity.
A
rich
saturated
fats
palmitic
acid,
found
many
highly
processed
foods,
provides
substrates
for
synthetic
enzymes
synthase
6
(CERS6)
5
(CERS5),
which
are
expressed
central
nervous
system.
Using
experimental
autoimmune
encephalomyelitis
(EAE)
model
inflammatory
demyelination,
we
show
here
that
mice
with
CamK2a+
neuronal
specific
deletion
both
CerS6
CerS5
milder
course
EAE
than
wild
type
mice,
even
when
fed
enriched
acid.
At
cellular
level,
neurons
lacking
protected
mitochondrial
dysfunction
arising
exposure
oxidative
stress
acid
medium.
These
data
underscore
healthy
avoiding
foods
disorders
identifies
endogenous
an
important
determinant
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(18), P. 4009 - 4009
Published: Sept. 16, 2023
Currently
available
data
suggest
that
the
union
of
a
balanced
diet
and
an
overall
healthy
lifestyle
may
determine
amelioration
in
several
clinical
parameters
quality
life
for
patients
with
MS
(pwMS).
The
study
objective
was
to
investigate
possible
difference
severity
group
Italian
based
on
their
adherence
Mediterranean
Diet
(MedDiet).
Eating
habits
were
collected
through
validated
110-items
Food
Frequency
Questionnaire,
Medi-Lite
score
used
MedDiet
evaluation.
graded
according
Herbert's
scale,
MSSS.
106
classified
3
groups
(low/medium/high).
Higher
associated
6.18
(95%
CI:
1.44,
26.59)
higher
probability
having
mild-to-moderate
MS.
When
studying
single
constituents
score,
none
them
individually
severity.
It
remains
unclear
whether
effects
specific
dietary
components
included
impact
health
status
at
disease
onset
or
can
slow
down
symptoms
due
course
disease.
Future
studies
are
needed
reproduce
our
findings
should
focus
answering
latter
raised
question.
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(24), P. 5095 - 5095
Published: Dec. 13, 2023
Inflammatory
status
is
one
of
the
main
drivers
in
development
non-communicable
diseases
(NCDs).
Specific
unhealthy
dietary
patterns
and
growing
consumption
ultra-processed
foods
(UPFs)
may
influence
inflammation
process,
which
negatively
modulates
gut
microbiota
increases
risk
NCDs.
Moreover,
several
chronic
health
conditions
require
special
long-term
treatment,
characterized
by
altered
ratios
intake
nutrients
or
disease-specific
foods.
In
this
narrative
review,
we
aimed
to
collect
latest
evidence
on
pro-inflammatory
potential
patterns,
foods,
children
affected
multifactorial
but
also
dietetic
approaches
used
as
treatment
for
specific
diseases.
Considering
diet-related
diseases,
triggering
effect
diets
has
been
addressed
metabolic
syndrome
inflammatory
bowel
latter
adults
only.
Future
research
required
multiple
sclerosis,
type
1
diabetes,
pediatric
cancer,
role
emerging.
For
requiring
diets,
single
possibly
associated
with
inflammation,
was
assessed,
more
studies
are
needed.
The
collected
highlighted
need
professionals
consider
entire
pattern,
providing
balanced
healthy
not
only
permit
control
disease
itself,
prevent
NCDs
adolescence
adulthood.
Personalized
nutritional
approaches,
close
collaboration
between
hospital,
country,
families,
must
always
be
promoted
together
new
methods
assessment
habits
age
implementation
telemedicine.
Immunometabolism,
Journal Year:
2023,
Volume and Issue:
5(2), P. e00022 - e00022
Published: April 1, 2023
This
review
summarizes
the
cellular
and
molecular
underpinnings
of
autoimmune
demyelinating
optic
neuritis
(ADON),
a
common
sequela
multiple
sclerosis
other
diseases.
We
further
present
nutritional
interventions
tested
for
people
with
focusing
on
strategies
that
have
shown
efficacy
or
associations
disease
course
clinical
outcomes.
then
close
by
discuss
potential
dietary
guidance
preventing
and/or
ameliorating
ADON.
Glia,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 3, 2024
Ceramide
C16
is
a
sphingolipid
detected
at
high
levels
in
several
neurodegenerative
disorders,
including
multiple
sclerosis
(MS).
It
can
be
generated
de
novo
or
from
the
hydrolysis
of
other
sphingolipids,
such
as
sphingomyelin
through
recycling
sphingosine,
what
known
salvage
pathway.
While
myelin
damage
occurring
MS
suggests
importance
hydrolytic
and
pathways,
growing
interest
on
diet
demyelinating
prompted
us
to
investigate
involvement
ceramide
synthesis
disease
severity.
A
rich
saturated
fats
palmitic
acid,
found
many
highly
processed
foods,
provides
substrates
for
synthetic
enzymes
synthase
6
(CERS6)
5
(CERS5),
which
are
expressed
central
nervous
system.
Using
experimental
autoimmune
encephalomyelitis
(EAE)
model
inflammatory
demyelination,
we
show
here
that
mice
with
CamK2a+
neuronal
specific
deletion
both
CerS6
CerS5
milder
course
EAE
than
wild
type
mice,
even
when
fed
enriched
acid.
At
cellular
level,
neurons
lacking
protected
mitochondrial
dysfunction
arising
exposure
oxidative
stress
acid
medium.
These
data
underscore
healthy
avoiding
foods
disorders
identifies
endogenous
an
important
determinant
