Transauricular vagus stimulation improves subthalamic beta power and gait in DOI Open Access
Massimo Marano,

Gaia Anzini,

Luca Saltarocchi

et al.

Authorea (Authorea), Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 11, 2023

Background: Transcutaneous vagus nerve stimulation (VNS) showed early evidence of efficacy for the gait treatment Parkinson's disease.Objectives: Providing data on neurophysiological and clinical effect transauricular VNS (taVNS).Methods: Ten PD patients with recording deep brain (DBS) have been enrolled in a within participant design study, double-blind crossover sham-controlled trial taVNS.Subthalamic local field potentials (beta band power), unified disease rating scales, digital timed up go test (TUG) were measured compared taVNS-ON vs. OFF during medication-off/DBS-off condition.Results: taVNS induced reduction beta power contralateral subthalamic nucleus an improvement total TUG time, speed variability.The taVNS-induced correlated speed.Discussions: could help management PD.The present result opens new trials chronic neuromodulation prospective cohorts.

Language: Английский

Transauricular vagus stimulation improves subthalamic beta power and gait in DOI Open Access
Massimo Marano,

Gaia Anzini,

Luca Saltarocchi

et al.

Authorea (Authorea), Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 11, 2023

Background: Transcutaneous vagus nerve stimulation (VNS) showed early evidence of efficacy for the gait treatment Parkinson's disease.Objectives: Providing data on neurophysiological and clinical effect transauricular VNS (taVNS).Methods: Ten PD patients with recording deep brain (DBS) have been enrolled in a within participant design study, double-blind crossover sham-controlled trial taVNS.Subthalamic local field potentials (beta band power), unified disease rating scales, digital timed up go test (TUG) were measured compared taVNS-ON vs. OFF during medication-off/DBS-off condition.Results: taVNS induced reduction beta power contralateral subthalamic nucleus an improvement total TUG time, speed variability.The taVNS-induced correlated speed.Discussions: could help management PD.The present result opens new trials chronic neuromodulation prospective cohorts.

Language: Английский

Citations

0