Published: March 5, 2024
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3805 - 3805
Published: March 29, 2024
The post-COVID condition (PCC) is a pathology stemming from COVID-19, and studying its pathophysiology, diagnosis, treatment crucial. Neuroinflammation causes the most common manifestations of this disease including headaches, fatigue, insomnia, depression, anxiety, among others. Currently, there are no specific management proposals; however, given that inflammatory component involves cytokines free radicals, these conditions must be treated to reduce current symptoms provide neuroprotection risk long-term neurodegenerative disease. It has been shown cannabis compounds with immunomodulatory antioxidant functions in other pathologies. Therefore, exploring approach could viable therapeutic option for PCC, which purpose review. This review involved an exhaustive search specialized databases PubMed, PubChem, ProQuest, EBSCO, Scopus, Science Direct, Web Science, Clinical Trials. Phytocannabinoids, cannabidiol (CBD), cannabigerol (CBG), Delta-9-tetrahydrocannabinol (THC), exhibit significant antioxidative anti-inflammatory properties have effective neuroinflammatory conditions. These promising adjuvants PCC alone or combination antioxidants therapies. presents challenges neurological health, neuroinflammation oxidative stress play central roles pathogenesis. Antioxidant therapy cannabinoid-based approaches represent areas research mitigating adverse effects, but further studies needed.
Language: Английский
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Frontiers in Aging Neuroscience, Journal Year: 2023, Volume and Issue: 15
Published: Oct. 20, 2023
The severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) and the сoronavirus disease 2019 (COVID-19) have become a global health threat. At height of pandemic, major efforts were focused on reducing COVID-19-associated morbidity mortality. Now is time to study long-term effects particularly cognitive impairment associated with long COVID. In recent years much attention has been paid possible relationship between COVID-19 Alzheimer’s disease, which considered main cause age-related impairment. Genetic predisposition was shown for both disease. However, analysis similarity genetic architecture these diseases usually limited indicating positive correlation them. this review, we described intrinsic linkages pointed out shared susceptibility genes that previously identified in genome-wide association studies highlighted panel SNPs includes candidate risk markers COVID-associated
Language: Английский
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Neurology International, Journal Year: 2024, Volume and Issue: 16(2), P. 380 - 393
Published: March 28, 2024
Long-COVID afflicts millions with relentless fatigue, disrupting daily life. The objective of this narrative review is to synthesize current evidence on the role basal ganglia in long-COVID discuss potential mechanisms, and highlight promising therapeutic interventions. A comprehensive literature search was conducted using PubMed, Scopus, Web Science databases. Mounting from PET, MRI, functional connectivity data reveals disturbances exhaustion, including inflammation, metabolic disruption, volume changes, network alterations focused striatal dopamine circuitry regulating motivation. Theories suggest inflammation-induced signaling could impede effort/reward valuation, disrupt cortical–subcortical motivational pathways, or diminish excitatory input arousal centers, attenuating drive initiation. Recent pilots targeting abnormalities show provisional efficacy. However, heterogeneous outcomes, inconsistent metrics, perceived versus fatigue discrepancies temper insights. Despite growing research, gaps remain understanding precise pathways linking dysfunction validating treatment Further research needed advance ganglia’s contribution neurological sequelae offer hope for improving function across expanding affected population.
Language: Английский
Citations
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Cells, Journal Year: 2024, Volume and Issue: 13(2), P. 131 - 131
Published: Jan. 11, 2024
A developing nervous system is particularly vulnerable to the influence of pathophysiological clues and injuries in perinatal period. Astrocytes are among first cells that react insults against tissue, presence pathogens, misbalance local tissue homeostasis, a lack oxygen trophic support. Under this background, it remains uncertain if induced astrocyte activation, recognized as astrogliosis, friend or foe for progressing neonatal neurodevelopment. Likewise, state reactivity considered one key factors discriminating between either initiation endogenous reparative mechanisms compensating aberrations structures functions triggering neurodegeneration. The responses activated modulated by neighboring neural cells, which exhibit broad immunomodulatory pro-regenerative properties secreting plethora active compounds (including interleukins chemokines, neurotrophins, reactive species, nitric oxide synthase complement components), engaged cell crosstalk paracrine manner. As extremely sensitive signaling molecules, even subtle changes composition concentration cellular secretome can have significant effects on brain. Thus, modulating activity other types their interactions with overreactive astrocytes might be promising strategy controlling astrogliosis.
Language: Английский
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Published: March 5, 2024
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Published: March 5, 2024
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Published: March 5, 2024
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Published: March 5, 2024
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Published: March 5, 2024
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Published: March 5, 2024
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