World of Medicine and Biology, Journal Year: 2024, Volume and Issue: 20(88), P. 146 - 146
Published: Jan. 1, 2024
Language: Английский
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: March 4, 2024
The coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 has been defined as the greatest global health and socioeconomic crisis of modern times. While most people recover after being infected with virus, a significant proportion them continue to experience issues weeks, months even years acute infection SARS-CoV-2. This persistence clinical symptoms in individuals for at least three onset or emergence new lasting more than two months, without any other explanation alternative diagnosis have named long COVID, long-haul post-COVID-19 conditions, chronic post-acute sequelae (PASC). Long COVID characterized constellation disorders that vary widely their manifestations. Further, mechanisms underlying are not fully understood, which hamper efficient treatment options. review describes predictors common related COVID's effects on central peripheral nervous system organs tissues. Furthermore, transcriptional markers, molecular signaling pathways risk factors such sex, age, pre-existing condition, hospitalization during phase COVID-19, vaccination, lifestyle presented. Finally, recommendations patient rehabilitation management, well therapeutical approaches discussed. Understanding complexity this disease, its across multiple organ systems overlapping pathologies possible paramount developing diagnostic tools treatments.
Language: Английский
Citations
27
Alzheimer s & Dementia, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 27, 2025
Abstract INTRODUCTION The study aimed to assess changes in the prevalence of dementia Singapore over past decade. METHODS Well‐being Elderly (WiSE) 2023 and WiSE 2013 studies were comprehensive, single‐phase, cross‐sectional surveys conducted among older adults aged ≥60 years Singapore. included 2010 1798 informants, whereas comprised 2565 2421 informants. RESULTS weighted based on 10/66 Diagnostic Research Group (DRG) criteria was 8.8% (95% confidence interval [CI]: 7.3–10.7) compared 10% CI: 8.7–11.5). proportion those with undiagnosed decreased significantly from 70.6% 51.5% ( p ‐value = 0.002). DISCUSSION A non‐significant 12% reduction 1.1–3.5) observed a decade, studies. Highlights decade varied by age group, ethnicity, employment status, health factors. 51.5%.
Language: Английский
Citations
1
The American Journal of Medicine, Journal Year: 2024, Volume and Issue: unknown
Published: May 1, 2024
Language: Английский
Citations
6
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3805 - 3805
Published: March 29, 2024
The post-COVID condition (PCC) is a pathology stemming from COVID-19, and studying its pathophysiology, diagnosis, treatment crucial. Neuroinflammation causes the most common manifestations of this disease including headaches, fatigue, insomnia, depression, anxiety, among others. Currently, there are no specific management proposals; however, given that inflammatory component involves cytokines free radicals, these conditions must be treated to reduce current symptoms provide neuroprotection risk long-term neurodegenerative disease. It has been shown cannabis compounds with immunomodulatory antioxidant functions in other pathologies. Therefore, exploring approach could viable therapeutic option for PCC, which purpose review. This review involved an exhaustive search specialized databases PubMed, PubChem, ProQuest, EBSCO, Scopus, Science Direct, Web Science, Clinical Trials. Phytocannabinoids, cannabidiol (CBD), cannabigerol (CBG), Delta-9-tetrahydrocannabinol (THC), exhibit significant antioxidative anti-inflammatory properties have effective neuroinflammatory conditions. These promising adjuvants PCC alone or combination antioxidants therapies. presents challenges neurological health, neuroinflammation oxidative stress play central roles pathogenesis. Antioxidant therapy cannabinoid-based approaches represent areas research mitigating adverse effects, but further studies needed.
Language: Английский
Citations
5
The Clinical Neuropsychologist, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 29
Published: Aug. 23, 2024
The coronavirus disease-2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has had a profound global impact on individual health and well-being in adults children. While most fully recover from COVID-19, relatively large subgroup continues to experience persistent physical, cognitive, emotional/behavioral symptoms beyond the initial infection period. World Health Organization termed this phenomenon "Post-COVID-19 Condition" (PCC), better known as "Long COVID." Due cognitive psychosocial symptoms, neuropsychologists often assess recommend treatment for individuals with Long COVID. However, guidance neuropsychologists' involvement clinical care, policy-making, research not yet been developed. authors of manuscript convened address critical gap develop working patients presenting
Language: Английский
Citations
5
Journal of Occupational and Environmental Medicine, Journal Year: 2024, Volume and Issue: 66(4), P. 349 - 357
Published: Feb. 2, 2024
Abstract Persistent symptoms are common after acute COVID-19, often referred to as long COVID. Long COVID may affect the ability perform activities of daily living, including work. occurs more frequently in those with severe COVID-19. This guidance statement reviews pathophysiology COVID-19 and provides pragmatic approaches symptoms, syndromes, conditions occupational setting. Disability laws workers’ compensation also addressed.
Language: Английский
Citations
4
Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11
Published: July 5, 2024
Background The neurological symptoms of Long COVID (LC) and the impact neuropsychological manifestations on people’s daily lives have been extensively described. Although a large body literature describes symptoms, validating this with objective measures is important. This study aims to identify describe effects cognition, balance, retinal fundus, determine whether duration influences cognitive impairment. Methods cross-sectional involved LC volunteers complaint from public health centers in northern Barcelona who participated between January 2022 March 2023. collected sociodemographic characteristics, information substance use, comorbidities, clinical data related COVID-19. We measured five domains using battery tests. Balance was assessed through posturography vascular involvement by retinography. Results A total 166 people complaints participated, 80.72% were women mean age 49.28 ± 8.39 years. most common self-reported concentration memory deficit (98.80%), brain fog (82.53%) insomnia (71.17%). 68.67% presented at least one domain, executive functions being frequent (43.98%). 51.52% participants exhibited dysfunctional pattern 9.2% showed some alteration retina. There no statistically significant differences impairment symptom duration. Conclusion Our findings contribute more comprehensive understanding pathology associated COVID. They highlight diversity presence abnormal balance patterns, These underscore necessity addressing management condition primary care follow-up pursuit multidisciplinary treatment.
Language: Английский
Citations
4
Diagnostic radiology and radiotherapy, Journal Year: 2025, Volume and Issue: 15(4), P. 7 - 22
Published: Jan. 28, 2025
INTRODUCTION: In people who have experienced a new coronavirus infection (COVID-19), long COVID disorders can manifest as persistent cognitive and neuropsychiatric that endanger daily activities psychosocial adaptation. The long-term persistence polymorphism of symptoms after COVID-19 is growing concern. It characterized by undulation, when some the may temporarily disappear then return again. As 2024, prevalence 6–7% in adults about 1% children. Using neuroimaging techniques an integral part timely diagnosis acute consequences associated with COVID-19. OBJECTIVE: To assess nature health complaints, features neurological compare them radiological changes brain post-COVID period. MATERIALS AND METHODS: For period from 2023–2024, 170 patients aged 18 to 60 years participated study, history established fact COVID-19, confirmed polymerase chain reaction (PCR) SARS-CoV-2. main socio-demographic clinical laboratory indicators were evaluated for all participants, further examination. neuropsychological examination, Montreal Cognitive Assessment Scale (MoCA), «10 words» A.R. was evaluated. Luria, «Schulte Tables», tests study state praxis various aspects gnosis, well subjective assessment 38 symptoms, which included: memory impairment, concentration, fatigue, anxiety, presence panic attacks, pain localizations, etc. examination included structural MRI 1 H-MRI, performed on SIGNA Architect 3 Tl tomograph (GE HealthCare, General Electric, USA). RESULTS: majority (n=170) represented women (80%). Over 2 ⁄ respondents belonged working-age population; average age 38.2±11.3 years. most common phase NCI were: increase body temperature above 38˚C, shortness breath during physical exertion, impaired consciousness. Most often period, presented following non-specific complaints: hair loss (56.6%), decreased/increased appetite (52.6%), different parts abdomen (45.7%), fluctuations blood pressure, frequency increased increasing (p<0.05). complaints pressure more severe According results 53.8% had kind disorder related functioning structures central peripheral nervous systems. anxiety depressive (30%), insomnia (14.6%), tension headache (13.1%), amnesia syndrome (6.2%). Dysthymia (2.3%), migraine asthenic perceptual postural dizziness (3.1%), mild impairment (1.5%), also detected. With MoCA, significant decrease general functions found 7.7% conducted experimental psychological revealed leading violations higher mental individuals: (7.7±1.7 norm 8), insufficiency memorization process (9.2±1.1 10), attention stability (1.01±0.3 <1), difficulties performing samples spatial (errors made 43.6%), optical-spatial gnosis (only 5.7% coped without errors). Attention drawn severity asthenia, 64.9% participants complained suffering studies, signs cortical atrophy (45%), focal (35%), cystic pineal (25%), hippocampal (15%). Changes ratios metabolites noted MRC – NAA/Cr (20%), Cho/Cr mI 10% cases. DISCUSSION: obtained within framework indicate predominantly modal-nonspecific factor lesion, is, processes activation/inactivation structures, contributing, among other things, occurrence above-mentioned states. described role damage first block according indicating persons postcovid area mediobasal cortex frontal lobes, hippocampus, stem structures. addition, imaging ultrastructural data (MRS) has potential be neuromarker manifestations syndrome. CONCLUSION: Post-COVID multi-systemic manifestations, while system lesions attributed complications caused demonstrates high versatility system, regardless disease, cases reflected studies. Future work involves use complex clinical, radiological, immunological, virological genetic search predisposing factors, understand mechanism pathogenesis, possible ways influence prevent development
Language: Английский
Citations
0
Applied Cognitive Psychology, Journal Year: 2025, Volume and Issue: 39(2)
Published: March 1, 2025
ABSTRACT Long COVID has widespread and long‐lasting multisystemic impacts on patients' bodies, cognition, daily functioning, including the ability to work. Longitudinal studies are important in investigating expected timelines along course of recovery. This mixed cross‐sectional/longitudinal study examines how symptoms (cognitive noncognitive) objective cognitive function evolve post‐COVID‐19 patients ( n = 187) compared noninfected controls 207). Participants completed a questionnaire about their COVID‐19 experience tasks at baseline again 2–3 follow‐ups during 9‐month period. While some noncognitive improved over time d s 0.34–0.87), neurological symptoms, as well memory assessed with assessments, remained unimproved (nonsignificant change time). Neurological predicted both impairment across time. Our finding suggested that people past infection did not improvement time, least for duration this longitudinal study.
Language: Английский
Citations
0
Life, Journal Year: 2025, Volume and Issue: 15(3), P. 439 - 439
Published: March 11, 2025
The COVID-19 (C-19) pandemic has highlighted the significance of understanding long-term effects this disease on quality life those infected. Long (L-C19) presents as persistent symptoms that continue beyond main illness period, usually lasting weeks to years. One lesser-known but significant aspects L-C19 is its impact neuropsychiatric manifestations, which can have a profound effect an individual’s life. Research shows creates issues such mental fog, emotional problems, and brain symptoms, along with sleep changes, extreme fatigue, severe head pain, tremors seizures, pain in nerves. People cognitive problems plus fatigue mood disorders experience great difficulty handling everyday activities, personal hygiene, social interactions. Neuropsychiatric make people withdraw from activity hurt relationships, thus causing feelings loneliness. unpredictable state generates heavy psychological pressure through suffering, including depression anxiety. changes impairment, swings it hard for work or study effectively, decreases their output at school lowers job contentment. purpose narrative review summarize clinical data present literature regarding manifestations L-C19, identify current methods diagnosis treatment lead correct management condition, highlight these patients’
Language: Английский
Citations
0