Status Epilepticus Treated With Vagus Nerve Stimulation in an Adult With Cortical Dysplasia: A Case Report DOI Open Access

Irene Gómez-Oropeza,

Valeria I Bravo-Osorno,

María F Castelo-Pablos

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 18, 2024

Status epilepticus (SE) is a neurological emergency characterized by prolonged seizures, with significant risks of neuronal injury and mortality. This case presents 60-year-old man drug-resistant epilepsy history recurrent seizures. His seizures began in early childhood persisted despite multiple anti-seizure medications. Notably, his semiology included the chapeau de gendarme sign, suggesting an involvement anterior cingulate cortex frontal lobe. Brain MRI revealed cortical dysplasia right inferior gyrus. Given high risk sudden unexpected death (SUDEP) due to frequent generalized tonic-clonic vagus nerve stimulation (VNS) was considered alternative therapy, future evaluation for surgical intervention involving lesionectomy. Following VNS implantation, SE arrested standard titration, within six months, patient achieved seizure freedom. demonstrates use controlling SE. Further research necessary determine optimal protocols

Language: Английский

Vagus nerve stimulation modulating the directed brain network of patients with drug-resistant epilepsy DOI
Mingming Chen,

Kunlin Guo,

Yongqiang Ding

et al.

Biomedical Signal Processing and Control, Journal Year: 2024, Volume and Issue: 95, P. 106361 - 106361

Published: April 19, 2024

Language: Английский

Citations

4
Successful application of vagus nerve stimulation in super refractory status epilepticus associated with MERRF syndrome DOI Creative Commons
Leyla Baysal-Kıraç,

Sabrina Jobi,

S. Zimmermann

et al.

Epilepsy & Behavior Reports, Journal Year: 2025, Volume and Issue: unknown, P. 100769 - 100769

Published: April 1, 2025

Language: Английский

Citations

0
Application of Neuromodulation Techniques in Super-Refractory Status Epilepticus DOI

灵 王

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(04), P. 1720 - 1727

Published: Jan. 1, 2025

Language: Английский

Citations

0
The effect of vagus nerve stimulation on heart rate and respiration rate and their impact on seizure susceptibility in anaesthetized rats under pentylenetetrazol DOI Creative Commons
Javier Chávez Cerda,

Elena Acedo Reina,

Ayse S. Dereli

et al.

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: March 21, 2025

Despite the proven efficacy of vagus nerve stimulation (VNS) in seizure control, its precise mechanism action remains unclear. VNS is known to impact cardiorespiratory system. In this study, we explored effects standard and breathing-synchronized on heart respiratory rates anesthetized epileptic rats, as well their susceptibility. Seizures were induced rats by intravenous pentylenetetrazol (PTZ) infusion. Three animal groups ( n = 4) subjected different types stimulation: Sham VNS, Standard Breathing-Synchronized VNS. Measurements included respiration, electrocardiogram, electroencephalogram, vagal electroneurogram. Each experiment began with a 5-min baseline period, followed PTZ infusion until tonic–clonic onset, confirmed video recording electroencephalogram. Results indicate that significantly decreased rate below levels for (−120.0 ± 69.1 bpm) (−84.9 61.0 bpm), overcoming increasing effect observed sham (+79.2 35.5 there was no recovery during OFF periods. Regarding breathing changes, group presented slight increase respect (+13.6 1.8 bpm). The slightly increased average (+13.0 14.6 (+13.7 10.4 however enlarged deviation. More specifically, pattern suggests experienced hypoxia under stimulation. modulation similar suggesting cumulative. Unexpectedly, required higher dose (79.7 13.4 mg/kg) reach seizures compared (57.9 9.8 mg/kg), (60.0 8.7 pointing an susceptibility particular model. Additionally, latency longer (291.5 84.4 s) (200.5 59.5 (206.9 66.0 s), meaning starting earlier. A significant linear relationship found between R 2 0.62, p -value 0.012). We hypothesize drop presence altered respiration patterns, such apneas or changes rates, caused are related hypotension conditions, which could PTZ. Future investigations larger sample sizes, incorporating blood pressure oxygen saturation monitoring, needed sort out role potential covariates affecting overstimulation. Such finding would support idea safety require adjustments.

Language: Английский

Citations

0
A Comprehensive Overview of the Current Status and Advancements in Various Treatment Strategies against Epilepsy DOI Creative Commons
Abdul Waris, Muhammad Siraj, Ayyaz Ali Khan

et al.

ACS Pharmacology & Translational Science, Journal Year: 2024, Volume and Issue: 7(12), P. 3729 - 3757

Published: Nov. 1, 2024

Epilepsy affects more than 70 million individuals of all ages worldwide and remains one the most severe chronic noncommunicable neurological diseases globally. Several neurotransmitters, membrane protein channels, receptors, enzymes, and, recently noted, various pathways, such as inflammatory mTORC complexes, play significant roles in initiation propagation seizures. Over past two decades, developments have been made diagnosis treatment epilepsy. Various pharmacological drugs with diverse mechanisms action other options developed to control seizures treat These include surgical treatment, nanomedicine, gene therapy, natural products, nervous stimulation, a ketogenic diet, gut microbiota, etc., which are developmental stages. Despite plethora options, one-third affected resistant current medications, while majority approved side effects, changes can occur, pharmacoresistance, effects on cognition, long-term problems, drug interactions, risks poor adherence, specific for certain psychological complications. Therefore, development new that no or minimal adverse is needed combat this deadly disease. In Review, we comprehensively summarize explain stages epilepsy well their status clinical trials advancements.

Language: Английский

Citations

2
Role of Vagus Nerve Stimulation in Refractory and Super Refractory Status Epilepticus: A Pediatric Case Series DOI Creative Commons
Giulia Melinda Furlanis, Jacopo Favaro,

Nicola Bresolin

et al.

Brain Sciences, Journal Year: 2023, Volume and Issue: 13(11), P. 1589 - 1589

Published: Nov. 14, 2023

Background: Status epilepticus is a life-threatening condition that defined as refractory (RSE) when the seizure activity continues despite treatment with benzodiazepine and second appropriate treatment. Super status (SRSE) an RSE persists or recurs for ≥24 h. Few papers have reported outcomes of pediatric patients affected by SRSE treated neuromodulation therapies. Vagus nerve stimulation (VNS) approved drug-resistant epilepsy. We present our findings VNS RSE/SRSE. Methods: case series seven consecutive since 2012 single surgeon in Monza Padua. A rapid titration was started soon after implantation. considered electroclinical data before implantation at last follow-up. Results: achieved resolution five out mean time two weeks. At follow-up, these had significant reduction burden without any relapse SE. Discussion Conclusions: Based on limited findings, we discuss potential role therapy similar but distinct clinical contexts. For epilepsy RSE/SRSE, prompt consideration suggested, offering responses potentially reducing pharmacological load. Meanwhile, NORSE/FIRES, suggest early during acute phase if standard treatments prove ineffective not tolerated. This approach may leverage VNS’s anti-inflammatory effects neuromodulation, enhancing patient-specific treatments. Expanding studies prolonged follow-ups are recommended to strengthen insights.

Language: Английский

Citations

5
NEUROMODULATION IN EPILEPSY: AN UPDATED REVIEW AND FUTURE PERSPECTIVES DOI Open Access

Lucas de Freitas Sommer,

Laurence Vezzani Ruschel,

Vanessa Lopes Senssulini

et al.

International Journal of Health Science, Journal Year: 2024, Volume and Issue: 4(11), P. 2 - 8

Published: Jan. 24, 2024

Objective: Evaluate and synthesize the most recent scientific evidence on neuromodulation techniques used in treatment of epilepsy, focusing advances future perspectives.Methodology: Narrative bibliographic review using PubMed database, search terms "Neuromodulation", "Transcutaneous Electric Nerve Stimulation", "Deep Brain "Vagal "Epilepsy", associated with Boolean operators "OR" "AND", resulting 982 articles, which only 18 became official sources study after applying inclusion exclusion criteria.Discussion: Studies demonstrate that are effective safe reducing number seizures patients epilepsy.Furthermore, it has direct effects quality life a greater probability survival patients, especially those epilepsy refractory to drug Final Considerations: The lack specific guidelines, such as intensity frequency stimulation, results heterogeneous longterm effects.Therefore, studies needed understand factors influence these develop even more stimulation protocols.

Language: Английский

Citations

0
Integrating the 5-SENSE Score for Patient Selection in Vagus Nerve Stimulation for Drug-Resistant Epilepsy DOI Open Access

Flavius Iuliu Urian,

Radu Eugen Rizea,

Horia Petre Costin

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 28, 2024

Addressing the challenge of drug-resistant epilepsy, our study offers a novel perspective by retrospectively applying 5-SENSE score, initially created for stereoelectroencephalography (SEEG) planning, to evaluate its predictive value in patients undergoing vagus nerve stimulation (VNS) therapy. We conducted comprehensive preoperative diagnostic work-up, including computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography-CT (PET-CT), video-electroencephalogram (video-EEG), and clinical semiology. then stratified 76 into three groups - low, moderate, high focality based on seizure-onset zone. Such stratification was made check scoring ability predicting VNS therapy seizure reduction. Our findings demonstrate an association between extent at zone effectiveness VNS, which may help define role score patient selection VNS. This dispersion responses group with reinforces idea that outcome estimation is difficult argues individualized strategy treatment epilepsy. A level indicates importance detailed assessments better optimize further improve outcomes.

Language: Английский

Citations

0
Status Epilepticus Treated With Vagus Nerve Stimulation in an Adult With Cortical Dysplasia: A Case Report DOI Open Access

Irene Gómez-Oropeza,

Valeria I Bravo-Osorno,

María F Castelo-Pablos

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 18, 2024

Status epilepticus (SE) is a neurological emergency characterized by prolonged seizures, with significant risks of neuronal injury and mortality. This case presents 60-year-old man drug-resistant epilepsy history recurrent seizures. His seizures began in early childhood persisted despite multiple anti-seizure medications. Notably, his semiology included the chapeau de gendarme sign, suggesting an involvement anterior cingulate cortex frontal lobe. Brain MRI revealed cortical dysplasia right inferior gyrus. Given high risk sudden unexpected death (SUDEP) due to frequent generalized tonic-clonic vagus nerve stimulation (VNS) was considered alternative therapy, future evaluation for surgical intervention involving lesionectomy. Following VNS implantation, SE arrested standard titration, within six months, patient achieved seizure freedom. demonstrates use controlling SE. Further research necessary determine optimal protocols

Language: Английский

Citations

0