Proof of concept: Portable ultra‐low‐field magnetic resonance imaging for the diagnosis of epileptogenic brain pathologies DOI Creative Commons
Tobias Bauer, Sebastian Olbrich,

Anne Groteklaes

et al.

Epilepsia, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 29, 2024

Abstract Objective High‐field magnetic resonance imaging (MRI) is a standard in the diagnosis of epilepsy. However, high costs and technical barriers have limited adoption low‐ middle‐income countries. Even high‐income nations, many individuals with epilepsy face delays undergoing MRI. Recent advancements ultra‐low‐field (ULF) MRI technology, particularly development portable scanners, offer promising solution to accessibility In this study, we present evaluate capability ULF detecting structural abnormalities typically associated compare it high‐field at 3 T. Methods Data collection was conducted within consecutive weeks University Hospital Bonn. Inclusion criteria were minimum age 18 years, diagnosed epilepsy, clinical abnormalities. We used .064 T Swoop MR Imaging System. Both scans evaluated independently by two experienced neuroradiologists as part their routine, comparing pathology detection completeness. Results Twenty‐three recruited. One subject presented dual pathology. Across entire cohort, 17 24 (71%) pathologies, an anomaly colocalizing actual lesion observed on For 11 (46%) full could be made based Tumors posttraumatic lesions best MRI, whereas cortical dysplasia other focal pathologies least well diagnosed. Significance This single‐center series demonstrates feasibility utility for field epileptology. Its integration into care offers transformative potential, resource‐limited settings. Further research needed position modalities

Language: Английский

UNITY: A low-field magnetic resonance neuroimaging initiative to characterize neurodevelopment in low and middle-income settings DOI Creative Commons
Firehiwot Workneh,

Amanda Adu-Amankwah,

KA Ae-Ngibise

et al.

Developmental Cognitive Neuroscience, Journal Year: 2024, Volume and Issue: 69, P. 101397 - 101397

Published: May 31, 2024

Measures of physical growth, such as weight and height have long been the predominant outcomes for monitoring child health evaluating interventional in public studies, including those that may impact neurodevelopment. While growth generally reflects overall nutritional status, it lacks sensitivity specificity to brain developing cognitive skills abilities. Psychometric tools, e.g., Bayley Scales Infant Toddler Development, afford more direct assessment development but they require language translation, cultural adaptation, population norming. Further, are not always reliable predictors future when assessed within first 12-18 months a child's life. Neuroimaging provide objective, sensitive, predictive measures neurodevelopment tools magnetic resonance (MR) imaging readily available many low middle-income countries (LMICs). MRI systems operate at lower fields (< 100mT) offer increased accessibility, their use global studies remains nascent. The UNITY project is envisaged partnership advance neuroimaging studies. Here we describe project, its goals, methods, operating procedures, expected characterizing sub-Saharan Africa South Asia.

Language: Английский

Citations

9
Feasibility and Usability of Low-Field Magnetic Resonance Imaging for Pediatric Neuroimaging in Low- and Middle-Income Countries: A Qualitative Study DOI Creative Commons

Erin Rowand,

Rosemond Owusu,

Alexandra Sibole

et al.

Medical Devices Evidence and Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 107 - 121

Published: Feb. 1, 2025

The burden of neurological disorders in low- and middle-income countries (LMICs) may be underestimated due to the limited number diagnostic imaging devices trained specialists operate interpret scans. Recent advancements low-field (<100 milliteslas) magnetic resonance (LFMRI) hold significant promise for improving access pediatric neuroimaging technology's lower costs, portability, reduced infrastructure training requirements. Explore user needs experiences on use a portable LFMRI LMICs. We conducted qualitative interviews with end users systems across 11 sites Bangladesh, Ethiopia, Ghana, Malawi, Pakistan, South Africa, Uganda, Zambia. A semi-structured questionnaire open-ended questions usability feasibility was used encourage participants share their opinions ease use, satisfaction, integration into local health systems. Among 46 participants, key challenges were reported infant positioning, power stability, internet connectivity. Suggestions included developing reference materials content format tailored contexts, conducting refresher trainings, providing education that includes technical maintenance support crucial appropriate utilization implementation sustainability. This study underscores importance incorporating human-centered design principles feedback identifying resolving issues, sharing insights successful within existing care infrastructures LMICs, optimizing populations.

Language: Английский

Citations

0
An evaluation of the current status of quality assurance program in MRI: A multicenter study DOI

D. G. Palací López,

Helen’s Irais Sánchez Mendoza, Erick H. Pasaye

et al.

Radiography, Journal Year: 2025, Volume and Issue: 31(3), P. 102908 - 102908

Published: March 15, 2025

Language: Английский

Citations

0
Ultra-low-field brain MRI morphometry: test-retest reliability and correspondence to high-field MRI DOI Creative Commons
František Váša,

Carly Bennallick,

Niall Bourke

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 19, 2024

Magnetic resonance imaging (MRI) enables non-invasive monitoring of healthy brain development and disease. Widely used higher field (>1.5 T) MRI systems are associated with high energy infrastructure requirements, costs. Recent ultra-low-field (<0.1T) provide a more accessible cost-effective alternative. However, it is not known whether anatomical neuroimaging can be to extract quantitative measures morphometry, what extent such correspond high-field MRI. Here we scanned 23 adults aged 20-69 years on two identical 64 mT 3 T system, using 1 w 2 scans across range (64 mT) resolutions. We segmented images into 4 global tissue types 98 local structures, systematically evaluated between-scanner reliability morphometry correspondence measurements, correlations volume Dice spatial overlap segmentations. report scan contrasts resolutions, highest performance shown by combining three low through-plane resolution single higher-resolution multi-resolution registration. Larger structures show T. Finally, showcase the potential for mapping neuroanatomical changes lifespan, relevant neurological disorders. Raw code publicly available ( upon publication ), enabling systematic validation pre-processing analysis approaches neuroimaging.

Language: Английский

Citations

3
Low-field MRI for use in neurological diseases DOI
Sharada Balaji,

Neale Wiley,

Megan E. Poorman

et al.

Current Opinion in Neurology, Journal Year: 2024, Volume and Issue: 37(4), P. 381 - 391

Published: May 30, 2024

Purpose of review To recent clinical uses low-field magnetic resonance imaging (MRI) to guide incorporation into neurological practice. Recent findings Use MRI has been demonstrated in applications including tumours, vascular pathologies, multiple sclerosis, brain injury, and paediatrics. Safety, workflow, image quality have also evaluated. Summary Low-field the potential increase access critical for patients who otherwise may not obtain a timely manner. This includes areas such as intensive care unit emergency room, where could be imaged at point rather than transported scanner. Such systems are often more affordable conventional systems, allowing them easily deployed resource constrained settings. A variety available on market or research setting currently being used determine these devices. The utility devices must fully evaluated scenarios before adoption standard practice can achieved. summarizes MR well safety, workflows, aid practitioners assessing this new technology.

Language: Английский

Citations

2
Super-Field MRI Synthesis for Infant Brains Enhanced by Dual Channel Latent Diffusion DOI
Austin Tapp, Can Zhao, Holger R. Roth

et al.

Lecture notes in computer science, Journal Year: 2024, Volume and Issue: unknown, P. 444 - 454

Published: Jan. 1, 2024

Language: Английский

Citations

1
Proof of concept: Portable ultra‐low‐field magnetic resonance imaging for the diagnosis of epileptogenic brain pathologies DOI Creative Commons
Tobias Bauer, Sebastian Olbrich,

Anne Groteklaes

et al.

Epilepsia, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 29, 2024

Abstract Objective High‐field magnetic resonance imaging (MRI) is a standard in the diagnosis of epilepsy. However, high costs and technical barriers have limited adoption low‐ middle‐income countries. Even high‐income nations, many individuals with epilepsy face delays undergoing MRI. Recent advancements ultra‐low‐field (ULF) MRI technology, particularly development portable scanners, offer promising solution to accessibility In this study, we present evaluate capability ULF detecting structural abnormalities typically associated compare it high‐field at 3 T. Methods Data collection was conducted within consecutive weeks University Hospital Bonn. Inclusion criteria were minimum age 18 years, diagnosed epilepsy, clinical abnormalities. We used .064 T Swoop MR Imaging System. Both scans evaluated independently by two experienced neuroradiologists as part their routine, comparing pathology detection completeness. Results Twenty‐three recruited. One subject presented dual pathology. Across entire cohort, 17 24 (71%) pathologies, an anomaly colocalizing actual lesion observed on For 11 (46%) full could be made based Tumors posttraumatic lesions best MRI, whereas cortical dysplasia other focal pathologies least well diagnosed. Significance This single‐center series demonstrates feasibility utility for field epileptology. Its integration into care offers transformative potential, resource‐limited settings. Further research needed position modalities

Language: Английский

Citations

1