Bidirectional relationship between depression and activities of daily living and longitudinal mediation of cognitive function in patients with Parkinson’s disease DOI Creative Commons
Yue Xu, Durong Chen,

Meiqi Dong

et al.

Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 17

Published: Feb. 12, 2025

Objective To investigate the bidirectional relationship between depression and activities of daily living (ADL) in Parkinson’s disease (PD) patients explore mediating role cognitive function over time. Methods Data from 892 PD Progression Markers Initiative (PPMI) database were included this study, depression, function, ADL measured using Geriatric Depression Scale (GDS-15), Montreal Cognitive Assessment (MoCA), Unified Disease Rating Scale, Part II (UPDRS II) respectively. The cross-lagged panel model (CLPM) was employed to analyze reciprocal ADL. Then, we explored with PD, mediation effect test carried out a bias-corrected nonparametric percentile bootstrap approach. Results predicted their subsequent ( β = 0.079, p < 0.01), also 0.069, 0.05), In addition, Bootstrap analysis showed that played significant prediction 0.006, 0.074, 95%CI 0.001 ~ 0.014), 0.067, 0.013). Conclusion There is PD. Furthermore, found mediates exists Interventions aimed at enhancing could potentially lessen vicious cycle thus improving patient quality life (QOL).

Language: Английский

Association between weekend catch-up sleep and depression in US adults DOI Creative Commons

Lingying Le,

Ziwei Lan, Chenxi Chen

et al.

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 4, 2025

Language: Английский

Citations

0
Bidirectional relationship between depression and activities of daily living and longitudinal mediation of cognitive function in patients with Parkinson’s disease DOI Creative Commons
Yue Xu, Durong Chen,

Meiqi Dong

et al.

Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 17

Published: Feb. 12, 2025

Objective To investigate the bidirectional relationship between depression and activities of daily living (ADL) in Parkinson’s disease (PD) patients explore mediating role cognitive function over time. Methods Data from 892 PD Progression Markers Initiative (PPMI) database were included this study, depression, function, ADL measured using Geriatric Depression Scale (GDS-15), Montreal Cognitive Assessment (MoCA), Unified Disease Rating Scale, Part II (UPDRS II) respectively. The cross-lagged panel model (CLPM) was employed to analyze reciprocal ADL. Then, we explored with PD, mediation effect test carried out a bias-corrected nonparametric percentile bootstrap approach. Results predicted their subsequent ( β = 0.079, p < 0.01), also 0.069, 0.05), In addition, Bootstrap analysis showed that played significant prediction 0.006, 0.074, 95%CI 0.001 ~ 0.014), 0.067, 0.013). Conclusion There is PD. Furthermore, found mediates exists Interventions aimed at enhancing could potentially lessen vicious cycle thus improving patient quality life (QOL).

Language: Английский

Citations

0