The Role of the Gut Microbiota in Modulating Signaling Pathways and Oxidative Stress in Glioma Therapies

Cancers, Journal Year: 2025, Volume and Issue: 17(5), P. 719 - 719

Published: Feb. 20, 2025

Tumors of the central nervous system (CNS), especially gliomas, pose a significant clinical challenge due to their aggressive nature and limited therapeutic options. Emerging research highlights critical role gut microbiota in regulating CNS health disease. The composition is essential for maintaining homeostasis, as it modulates immune responses, oxidative status, neuroinflammation. microbiota–gut–brain axis, bidirectional communication network, plays pivotal cancer disease treatment, exerting its influence through neural, endocrine, immunological, metabolic pathways. Recent studies suggest that influences solidification tumor microenvironment dysbiosis may promote glioma development by modulating systemic inflammation stress, which contributes tumorigenesis progression. This review interrogates impact on glioma, focusing pathways such NF-κB, MAPK, PI3K/Akt/mTOR, Kynurenine/AhR drive proliferation, evasion, therapy resistance. Furthermore, we explore emerging strategies, including probiotics microbiota-based interventions, show potential these enhancing immunotherapies checkpoint inhibitors. By multifaceted interactions between microbiota, tumors, this microbiota-targeted therapies manipulation complement enhance current treatments.

Language: Английский

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Gut microbiota and their influence in brain cancer milieu

Journal of Neuroinflammation, Journal Year: 2025, Volume and Issue: 22(1)

Published: May 1, 2025

Microbial communities are not simply remnants of the past but dynamic entities that continuously evolve under selective pressures nature, reflecting intricate and adaptive processes evolution. The microbiota residing in various regions human body has numerous roles different physiological such as nutrition, metabolism, immune regulation, etc. In zeal achieving empirical insights into ambit gut microbiome, research over years led to revelation reciprocal interaction between microbiome cognitive functioning body. Dysbiosis microbial composition disturbs homeostatic This dysbiosis been associated with chronic diseases, including brain cancer, glioma, glioblastoma, review explores mechanistic role dysbiosis-mediated progression cancers their subtypes. Moreover, it demonstrates regulatory metabolites produced by microbiota, short-chain fatty acids, amino lipids, etc., tumour progression. Further, we also provide valuable mediating efficiency therapeutic regimens, thereby leveraging potential biomarkers targets for improved treatment outcomes.

Language: Английский

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The Role of Gut Microbiome on Glioblastoma Oncogenesis and Malignant Evolution

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 2935 - 2935

Published: March 24, 2025

Glioblastoma (GBM) remains the most aggressive primary brain tumor, with poor survival outcomes and treatment limited to maximal safe surgical resection, chemotherapy temozolomide, radiotherapy. While immunotherapy targeted treatments show promise, therapeutic resistance disease progression remain major challenges. This is partly due GBM's classification as a "cold tumor" low mutational burden lack of distinct molecular targets for drug delivery that selectively spare healthy tissue. Emerging evidence highlights gut microbiota key player in cancer biology, influencing both glioma development response. review explores intersectionality between microbiome GBM, beginning an overview composition its broader implications pathophysiology. We then examine how specific microbial populations contribute oncogenesis, modulating immune responses, inflammation, metabolic pathways drive tumor initiation progression. Additionally, we discuss microbiome's role resistance, including impact on chemotherapy, radiotherapy, efficacy. Given influence outcomes, evaluate emerging strategies modulate flora, such probiotics, dietary interventions, microbiota-based therapeutics, enhance therapy response GBM patients. Finally, address challenges future directions, emphasizing need standardized methodologies, mechanistic studies, clinical trials validate microbiota-targeted interventions neuro-oncology. By integrating research into paradigms, may unlock novel avenues improve patient outcomes.

Language: Английский

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Gut brain axis and gut microbiome in glioblastoma. Associations, treatment and outcomes

Medicine in Microecology, Journal Year: 2025, Volume and Issue: unknown, P. 100131 - 100131

Published: May 1, 2025

Language: Английский

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