Association between serum carotenoids levels and severe headache or migraine in adults: a cross-sectional study from NHANES DOI Creative Commons
Hu Tian, Yufei Chen, Siyu Chen

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 6, 2025

Carotenoids are well-established for their potent antioxidant properties; however, potential association with severe headaches or migraines remains largely unexamined. This study was conducted to explore the relationship between serum carotenoid levels and prevalence of within US population. We utilized data from 2001-2004 National Health Nutrition Examination Survey (NHANES), which comprised a total 8,910 participants. Serum levels-specifically α-carotene, β-carotene, β-cryptoxanthin, lutein/zeaxanthin, lycopene-were quantified using high-performance liquid chromatography. Migraine status determined based on questionnaire. The research methodologies employed included multivariate logistic regression, subgroup analysis, restricted cubic spline (RCS) models. in population 22.37%. Multivariate regression analysis indicated that concentrations α-carotene (OR = 0.91, 95% CI: 0.85-0.97), β-carotene 0.88, 0.81-0.94), β-cryptoxanthin 0.83, 0.76-0.90), lutein/zeaxanthin 0.75, 0.67-0.85), carotenoids 0.79, 0.70-0.90) were significantly inversely correlated migraines; no significant found lycopene levels. RCS showed had an L-shaped non-linear migraine at threshold approximately 9.392 μg/dL, while analyses confirmed consistent inverse across various groups. incidence adults. evidence indicates may provide protective effect against further investigation is warranted substantiate these associations elucidate underlying mechanisms.

Language: Английский

Association between serum carotenoids levels and severe headache or migraine in adults: a cross-sectional study from NHANES DOI Creative Commons
Hu Tian, Yufei Chen, Siyu Chen

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 6, 2025

Carotenoids are well-established for their potent antioxidant properties; however, potential association with severe headaches or migraines remains largely unexamined. This study was conducted to explore the relationship between serum carotenoid levels and prevalence of within US population. We utilized data from 2001-2004 National Health Nutrition Examination Survey (NHANES), which comprised a total 8,910 participants. Serum levels-specifically α-carotene, β-carotene, β-cryptoxanthin, lutein/zeaxanthin, lycopene-were quantified using high-performance liquid chromatography. Migraine status determined based on questionnaire. The research methodologies employed included multivariate logistic regression, subgroup analysis, restricted cubic spline (RCS) models. in population 22.37%. Multivariate regression analysis indicated that concentrations α-carotene (OR = 0.91, 95% CI: 0.85-0.97), β-carotene 0.88, 0.81-0.94), β-cryptoxanthin 0.83, 0.76-0.90), lutein/zeaxanthin 0.75, 0.67-0.85), carotenoids 0.79, 0.70-0.90) were significantly inversely correlated migraines; no significant found lycopene levels. RCS showed had an L-shaped non-linear migraine at threshold approximately 9.392 μg/dL, while analyses confirmed consistent inverse across various groups. incidence adults. evidence indicates may provide protective effect against further investigation is warranted substantiate these associations elucidate underlying mechanisms.

Language: Английский

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