Role of Antioxidants in Modulating the Microbiota–Gut–Brain Axis and Their Impact on Neurodegenerative Diseases DOI Open Access
Natalia Kurhaluk, Piotr Kamiński, Rafał Bilski

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3658 - 3658

Published: April 12, 2025

This narrative review presents the role of antioxidants in regulating gut microbiota and impact on gut–brain axis, with a particular focus neurodegenerative diseases, such as Alzheimer’s (AD) Parkinson’s disease (PD). These diseases are characterised by cognitive decline, motor dysfunction, neuroinflammation, all which significantly exacerbated oxidative stress. elucidates contribution damage to progression explores potential mitigate these pathological processes through modulation associated pathways. Based recent studies retrieved from reputable databases, including PubMed, Web Science, Scopus, this article outlines mechanisms influence health exert neuroprotective effects. Specifically, it discusses how antioxidants, polyphenols, vitamins, flavonoids, contribute reduction reactive oxygen species (ROS) production thereby promoting neuronal survival minimising brain. In addition, modulating key molecular pathways involved stress NF-κB, Nrf2, MAPK, PI3K/AKT pathways, regulate ROS generation, inflammatory cytokine expression, antioxidant responses essential for maintaining cellular homeostasis both central nervous system. complex relationship between gut-derived metabolites, stress, highlighting dysbiosis—an imbalance microbiota—can exacerbate accelerating AD PD. The also examines short-chain fatty acids (SCFAs) produced beneficial bacteria attenuate neuroinflammation damage. Furthermore, therapeutic microbiota-targeted interventions, delivery probiotics prebiotics, innovative strategies restore microbial support brain health. By synthesising current knowledge interplay underlying neurodegeneration, highlights promise antioxidant-based interventions mitigating progression. It need further research into antioxidant-rich dietary microbiota-focused therapies promising avenues prevention treatment diseases.

Language: Английский

EXPLORING THE MICROBIOTA-INTESTINE-BRAIN AXIS IN PARKINSON'S DISEASE AND THE POTENTIAL OF FECAL MICROBIOTA TRANSPLANTATION (FMT) THERAPY DOI Open Access

Mariana Yukari Aguena,

Atsushi Ogata, José Baptista

et al.

International Journal of Health Science, Journal Year: 2025, Volume and Issue: 5(5), P. 1 - 6

Published: Jan. 16, 2025

Objective: To evaluate the relationship between gut microbiota and progression of Parkinson's Disease, focusing on potential improvements provided by TMF, as well discussing applicability this approach a therapeutic intervention for PD patients.Methodology: Narrative bibliographic review, developed according to criteria PVO strategy.The searches were carried out in PubMed database.The search terms included "Parkinson's disease", "Fecal transplant" their combinations.A total 17 articles published 2019 2024 selected detailed analysis.Discussion: In PD, BMT can reduce activation microglia astrocytes, decrease levels pro-inflammatory cytokines such TNF-α IL-6, preserving dopaminergic neurons improving motor deficits.In addition, TMF also interferes with pathological mechanisms, aggregation α-synuclein (αSyn), potentially interrupting action endotoxin-producing gram-negative bacteria.This modulation, turn, reduces production bacterial enzymes that degrade levodopa, increasing its bioavailability efficacy.Therefore, interaction reinforces an adjunct management PD.Final considerations: Beneficial changes include increase anti-inflammatory taxa, Faecalibacterium Bifidobacterium, reduction pathogens, Escherichia-Shigella , resulting non--motor symptoms, constipation depression.Despite advances future studies should rigorously controlled clinical trials, randomization standardization, validate efficacy safety, elucidating mechanisms metabolites neuroinflammation.

Language: Английский

Citations

0
Neuropharmacological Profile of Ḥabb-e-Ṣar‘: A Unani Pharmacopeial formulation for Epilepsy DOI Creative Commons
Mohammad Fazil, Sadia Nikhat

Phytomedicine Plus, Journal Year: 2025, Volume and Issue: 5(2), P. 100769 - 100769

Published: Feb. 28, 2025

Citations

0
Role of Antioxidants in Modulating the Microbiota–Gut–Brain Axis and Their Impact on Neurodegenerative Diseases DOI Open Access
Natalia Kurhaluk, Piotr Kamiński, Rafał Bilski

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3658 - 3658

Published: April 12, 2025

This narrative review presents the role of antioxidants in regulating gut microbiota and impact on gut–brain axis, with a particular focus neurodegenerative diseases, such as Alzheimer’s (AD) Parkinson’s disease (PD). These diseases are characterised by cognitive decline, motor dysfunction, neuroinflammation, all which significantly exacerbated oxidative stress. elucidates contribution damage to progression explores potential mitigate these pathological processes through modulation associated pathways. Based recent studies retrieved from reputable databases, including PubMed, Web Science, Scopus, this article outlines mechanisms influence health exert neuroprotective effects. Specifically, it discusses how antioxidants, polyphenols, vitamins, flavonoids, contribute reduction reactive oxygen species (ROS) production thereby promoting neuronal survival minimising brain. In addition, modulating key molecular pathways involved stress NF-κB, Nrf2, MAPK, PI3K/AKT pathways, regulate ROS generation, inflammatory cytokine expression, antioxidant responses essential for maintaining cellular homeostasis both central nervous system. complex relationship between gut-derived metabolites, stress, highlighting dysbiosis—an imbalance microbiota—can exacerbate accelerating AD PD. The also examines short-chain fatty acids (SCFAs) produced beneficial bacteria attenuate neuroinflammation damage. Furthermore, therapeutic microbiota-targeted interventions, delivery probiotics prebiotics, innovative strategies restore microbial support brain health. By synthesising current knowledge interplay underlying neurodegeneration, highlights promise antioxidant-based interventions mitigating progression. It need further research into antioxidant-rich dietary microbiota-focused therapies promising avenues prevention treatment diseases.

Language: Английский

Citations

0