Correlation between orbital imaging features of thyroid-associated ophthalmopathy and pupillary light reflex measurement DOI Creative Commons
Yan Li,

Z. Zhu,

Yanling Lu

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: March 21, 2025

Purpose This study aimed to assess the factors associated with quantitative pupillary light reflex analysis and orbital magnetic resonance imaging (MRI) indicators in thyroid-associated ophthalmopathy (TAO) patients different TAO severities, their diagnostic significance of dysthyroid optic neuropathy (DON). Methods A retrospective cross-sectional was conducted on 57 TAO, involving 109 orbits. Using EUGOGO severity grading system, were categorized into three groups: Mild (45 orbits), Moderate-to-Severe (48 DON (16 orbits). All participants underwent comprehensive ophthalmological assessments, using RAPDx device (Konan Medical), MRI (GE 3.0 Signa Creator, GE Medical Systems). measurements included bone wall area, extraocular muscle proptosis. Differences clinical characteristics, function indicators, MRI-derived analyzed Generalized Estimating Equations (GEE). Correlations trends between Latency Onset Constriction (LOC) assessed through Pearson multivariate linear regression models. The value LOC Volume Medial Orbital Wall (VMW) for diagnosing further evaluated Receiver Operating Characteristic (ROC) curve analysis. Results results revealed that significantly prolonged group compared both groups ( p < 0.05 both). demonstrated strong positive correlations Inferior Nerve Signal Loss (IONSL) r = 0.494, 0.001), Proptosis 0.448, Rectus Area (MRA) 0.428, 0.001). Multivariate binary logistic identified VMW as independent predictors DON. predictive model combining showed excellent performance, an Under Curve (AUC) 0.886 sensitivity 90.5%, specificity 82.4%. Conclusion These findings underscore critical roles evaluating TAO. significant IONSL, Proptosis, MRA, along its alongside VMW, highlight utility reliable markers

Language: Английский

Correlation between orbital imaging features of thyroid-associated ophthalmopathy and pupillary light reflex measurement DOI Creative Commons
Yan Li,

Z. Zhu,

Yanling Lu

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: March 21, 2025

Purpose This study aimed to assess the factors associated with quantitative pupillary light reflex analysis and orbital magnetic resonance imaging (MRI) indicators in thyroid-associated ophthalmopathy (TAO) patients different TAO severities, their diagnostic significance of dysthyroid optic neuropathy (DON). Methods A retrospective cross-sectional was conducted on 57 TAO, involving 109 orbits. Using EUGOGO severity grading system, were categorized into three groups: Mild (45 orbits), Moderate-to-Severe (48 DON (16 orbits). All participants underwent comprehensive ophthalmological assessments, using RAPDx device (Konan Medical), MRI (GE 3.0 Signa Creator, GE Medical Systems). measurements included bone wall area, extraocular muscle proptosis. Differences clinical characteristics, function indicators, MRI-derived analyzed Generalized Estimating Equations (GEE). Correlations trends between Latency Onset Constriction (LOC) assessed through Pearson multivariate linear regression models. The value LOC Volume Medial Orbital Wall (VMW) for diagnosing further evaluated Receiver Operating Characteristic (ROC) curve analysis. Results results revealed that significantly prolonged group compared both groups ( p < 0.05 both). demonstrated strong positive correlations Inferior Nerve Signal Loss (IONSL) r = 0.494, 0.001), Proptosis 0.448, Rectus Area (MRA) 0.428, 0.001). Multivariate binary logistic identified VMW as independent predictors DON. predictive model combining showed excellent performance, an Under Curve (AUC) 0.886 sensitivity 90.5%, specificity 82.4%. Conclusion These findings underscore critical roles evaluating TAO. significant IONSL, Proptosis, MRA, along its alongside VMW, highlight utility reliable markers

Language: Английский

Citations

0