Six-month follow-up of multidomain cognitive impairment in non-hospitalized individuals with post-COVID-19 syndrome

European Archives of Psychiatry and Clinical Neuroscience, Journal Year: 2024, Volume and Issue: 274(8), P. 1945 - 1957

Published: July 24, 2024

Abstract Some people infected with SARS-CoV-2 report persisting symptoms following acute infection. If these persist for over three months, they are classified as post-COVID-19 syndrome (PCS). Although PCS is frequently reported, detailed longitudinal neuropsychological characterization remains scarce. We aimed to describe the trajectory of cognitive and neuropsychiatric symptoms. 42 individuals deficits after asymptomatic mild/moderate COVID-19 at study inclusion received assessment baseline (BL) follow-up (FU; six months BL). Assessments included comprehensive testing five neurocognitive domains, two screening tests, questionnaires on depression, anxiety, sleep, fatigue, health-related quality life. Results showed high rates subjective complaints BL FU (95.2% versus 88.1%) without significant change time. However, objectively measured disorder (NCD) decreased (61.9% 42.9%). All domains were affected, yet most found in learning memory, followed by executive functions, complex attention, language, perceptual motor functions. In NCD, first mentioned improved significantly time, while last remained unchanged. Cognitive tests did not prove valuable detecting impairment. Neuropsychiatric constant except life, which improved. This emphasizes importance research provides insights into long-term impairments PCS. While performance many

Language: Английский

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Health Resort Treatment Mitigates Neuropsychiatric Symptoms in Long COVID Patients: A Retrospective Study

Healthcare, Journal Year: 2025, Volume and Issue: 13(2), P. 196 - 196

Published: Jan. 19, 2025

Background/Objectives: Among the neuropsychiatric symptoms of long COVID, following may be listed: sleep disturbances, headaches, anxiety, depression, dizziness, numbness, memory loss, and concentration difficulties. Various therapies have been implemented to mitigate these symptoms; however, health resort treatments that utilize a wide range modalities stimulating multidirectional biological reactions also effective. The aim this study was assess severity in COVID patients who qualified for treatment, evaluate effectiveness treatment group patients, effect balneological factors course. Methods: A retrospective analysis medical records 120 people with (69 women 51 men) aged 42–79 underwent 2021 performed. People were eligible at lowland based on valid referral from doctor. included therapies, physical medicine modalities, exercise programs, education, psychological support. Patients assessed persistent 0–10 point scale before after treatment. Results: After greatest improvement noted disorders (2.47 ± 2.23 points vs. 0.86 1.25 points, p < 0.00001) dizziness (1.39 1.94 0.34 0.76 0.00001). lowest observed (2.68 2.5 1 1.4 Conclusions: reported mild symptoms. Health mitigates symptoms, as it is complex approach. Treatment includes improves greater extent. This method should integrated into standard COVID.

Language: Английский

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Neuroinvasive and neurovirulent potential of SARS-CoV-2 in the acute and post-acute phase of intranasally inoculated ferrets

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(4), P. e0311449 - e0311449

Published: April 7, 2025

Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) can cause systemic disease, including neurological complications, even after mild disease. Previous studies have shown that SARS-CoV-2 infection induce neurovirulence through microglial activation in the brains of patients and experimentally inoculated animals, which are models representative for moderate to severe Here, we aimed investigate neuroinvasive neurovirulent potential intranasally ferrets, a model subclinical The presence viral RNA, histological lesions, virus-infected cells, number surface area microglia astrocytes were investigated. Viral RNA was detected various tissue samples by qPCR at 7 days post inoculation (dpi). Virus antigen nasal turbinates ferrets sacrificed dpi associated with inflammation. dpi, but situ hybridization nor immunohistochemistry did confirm evidence or brain. Histopathological analysis showed no an influx inflammatory cells. Despite this, observed increased Alzheimer type II hindbrains ferrets. Additionally, olfactory bulb hippocampus, decrease astrocytic status white matter hippocampus In conclusion, although has limited this there is potential. This study highlights value ferret neuropathogenecity reveals affect both different parts

Language: Английский

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Sleep Quality Mediates the Effect of Sensitization-Associated Symptoms, Anxiety, and Depression on Quality of Life in Individuals with Post-COVID-19 Pain

Brain Sciences, Journal Year: 2022, Volume and Issue: 12(10), P. 1363 - 1363

Published: Oct. 8, 2022

A better understanding of biological and emotional variables associated with health-related quality life in people long-COVID is needed. Our aim was to identify potential direct indirect effects on the relationships between sensitization-associated symptoms, mood disorders such as anxiety/depressive levels, sleep suffering from post-COVID-19 pain. One hundred forty-six individuals who were hospitalized due COVID-19 during first wave pandemic long-term pain completed different patient-reported outcome measures (PROMs), including clinical features, symptoms sensitization central nervous system (Central Sensitization Inventory), (Hospital Anxiety Depressive Scale), (Pittsburgh Sleep Quality Index), (paper-based five-level version EuroQol-5D) a face-to-face interview conducted at 18.8 (SD 1.8) months after hospitalization. Different mediation models assess associations among variables. The revealed that depressive levels directly affected life; however, these not statistically significant when included. In fact, effect symptomatology (β = -0.10, 95% CI -0.1736, -0.0373), (β= -0.09, -0.1789, -0.0314), anxiety -0.1648, -0.0337) all indirectly mediated by quality. This study mediates relationship (depressive/anxiety levels) reporting Longitudinal studies will help determine implications findings.

Language: Английский

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Device-assessed physical activity and sleep quality of post-COVID patients undergoing a rehabilitation program

BMC Sports Science Medicine and Rehabilitation, Journal Year: 2024, Volume and Issue: 16(1)

Published: May 29, 2024

Abstract Background An infection with SARS-CoV-2 can lead to persistent symptoms more than three months after the acute and has also an impact on patients’ physical activity behaviour sleep quality. There is evidence, that inpatient post-COVID rehabilitation improve capacity mental health impairments, but less known about change in Methods This longitudinal observational study used accelerometery assess level of quality before program. The sample consists 100 patients who acquired COVID-19 workplace. Group differences related sex, age, severity, pre-existing diseases were analysed. Results Level didn’t increase rehabilitation. Overall, there a high extent inactivity time poor at both measurement points. Regarding group differences, male showed significantly higher rehabilitation, younger (< 55 years) spend significant vigorous older patients. Post-COVID cardiovascular, respiratory, metabolic disease show slightly without these comorbidities. Female better some parameters However, no could be detected severity. Conclusions Ongoing strategies should implemented address amount

Language: Английский

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The Dual-Targeted Fusion Inhibitor Clofazimine Binds to the S2 Segment of the SARS-CoV-2 Spike Protein

Published: March 4, 2024

Clofazimine and Arbidol have both been reported to be effective in vitro SARS-CoV-2 fusion inhibitors. Both are promising drugs repurposed for treatment of COVID-19 used several previous ongoing clinical trials. Small-molecule binding expressed constructs the trimeric S2 segment Spike full-length spike protein were measured using a Surface Plasmon Resonance (SPR) assay. We demonstrate that Clofazimine, Toremifene, other derivatives bind protein. provided most reliable highest quality SPR data over conditions explored. A molecular docking approach was identify favorable sites on prefusion conformation, highlighting two possible small-molecule Results from modeling structure-activity-relationship (SAR) newly series supports proposed site segment. When is superimposed with experimentally determined coronavirus structures structure-sequence alignments, changes sequence structure may rationalize broad-spectrum antiviral activity closely related such as (SARS-CoV, MERS, hCoV-229E, hCoV-OC43).

Language: Английский

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“Brain Fog” as a symptom of the “Long-COVID” syndrome, its impact on the mental health of those affected by COVID-19 and its treatment

Deleted Journal, Journal Year: 2024, Volume and Issue: 3(1), P. 358 - 358

Published: Jan. 23, 2024

The impact of the COVID-19 pandemic on people’s lives is dramatic. relationship between Brain Fog and Long-COVID, consequences mental health patients, its treatment are objectives this systematic review. An electronic search was carried out databases searched included PubMed, Emerald, EMBASE, Science Direct. Regarding review, data collection English papers with full bibliographies, abstracts, keywords, published in form last 2 years (2020–2022). findings indicate importance a holistic approach Post-COVID Fog. It also necessary for healthcare workers to investigate biological psychosocial background symptoms detail provide appropriate service. However, more scientific studies needed effectiveness approaches benefit public well-being.

Language: Английский

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Social impact of brain fog and analysis of risk factors: Long COVID in Japanese population

Annals of Clinical and Translational Neurology, Journal Year: 2024, Volume and Issue: 11(8), P. 2188 - 2200

Published: July 4, 2024

To reveal the clinical features and assess risk factors linked to brain fog its societal implications, including labor productivity, providing valuable insights for future care of individuals who have experienced coronavirus disease 2019 (COVID-19).

Language: Английский

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Quality of Sleep and Mental Symptoms Contribute to Health-Related Quality of Life after COVID-19 Pneumonia, a Follow-Up Study of More than 2 Years

Biomedicines, Journal Year: 2024, Volume and Issue: 12(7), P. 1574 - 1574

Published: July 16, 2024

A follow-up study was designed to assess correlations among physical signs, quality of sleep, common mental symptoms, and health-related life after moderate severe COVID-19 pneumonia. Daily changes in dyspnoea pulse oximetry were recorded (200 days), four evaluations (in >2 years) performed on cognitive performance, life. In a single center, 72 adults participated the (52.5 ± 13.7 years old), with no psychiatry/neurology/chronic lung/infectious diseases, chronic use corticosteroids/immunosuppressive therapy, or pregnancy. agendas showed delayed decreases scores compared heart rate recordings; however, minimal. Slight performance related general characteristics participants (obesity tobacco use) severity acute disease (MANCOVA,

Language: Английский

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Neuroinvasive and neurovirulent potential of SARS-CoV-2 in the acute and post-acute phase of intranasally inoculated ferrets

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 23, 2024

Abstract Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) can cause systemic disease, including neurological complications, even after mild disease. Previous studies have shown that SARS-CoV-2 infection induce neurovirulence through microglial activation in the brains of patients and experimentally inoculated animals, which are models representative for moderate to severe Here, we aimed investigate neuroinvasive neurovirulent potential intranasally ferrets, a model subclinical The presence viral RNA, histological lesions, virus-infected cells, number surface area microglia astrocytes were investigated. Viral RNA was detected various tissue samples by qPCR at 7 days post inoculation (dpi). Virus antigen nasal turbinates ferrets sacrificed dpi associated with inflammation. dpi, but situ hybridization nor immunohistochemistry did not verify evidence infection. Histopathological analysis showed no an influx inflammatory cells. Despite this, observed increased Alzheimer type II hindbrains ferrets. Additionally, olfactory bulb hippocampus, decrease astrocytic status white matter hippocampus In conclusion, although has limited this there is potential. This study highlights value ferret neuropathogenecity reveals affect both different parts brain.

Language: Английский

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