Cerebro-spinal somatotopic organization uncovered through functional connectivity mapping DOI Creative Commons
Caroline Landelle, Nawal Kinany, Benjamin De Leener

et al.

Imaging Neuroscience, Journal Year: 2024, Volume and Issue: 2, P. 1 - 14

Published: Jan. 1, 2024

Abstract Somatotopy, the topographical arrangement of sensorimotor pathways corresponding to distinct body parts, is a fundamental feature human central nervous system (CNS). Traditionally, investigations into brain and spinal cord somatotopy have been conducted independently, primarily utilizing stimulations or movements. To date, however, no study has probed somatotopic cerebro-spinal functional connections in vivo humans. In this study, we used simultaneous cervical magnetic resonance imaging (fMRI) demonstrate how coordinated activities these two CNS levels at rest can reveal their shared somatotopy. Using connectivity analyses, mapped preferential correlation patterns between each segment regions, revealing gradient within cortical network. We then validated large-scale organization through complementary data-driven analysis, where effectively identified segments profiles voxels with cortex. These findings underscore potential resting-state fMRI probe minimal experimental burden, holding promise for gaining more comprehensive understanding normal impaired somatosensory-motor functions.

Language: Английский

Innovations in acute and chronic pain biomarkers: enhancing diagnosis and personalized therapy DOI Creative Commons
Sean Mackey, Nima Aghaeepour, Brice Gaudillière

et al.

Regional Anesthesia & Pain Medicine, Journal Year: 2025, Volume and Issue: 50(2), P. 110 - 120

Published: Feb. 1, 2025

Pain affects millions worldwide, posing significant challenges in diagnosis and treatment. Despite advances understanding pain mechanisms, there remains a critical need for validated biomarkers to enhance diagnosis, prognostication, personalized therapy. This review synthesizes recent advancements identifying validating acute chronic biomarkers, including imaging, molecular, sensory, neurophysiological approaches. We emphasize the emergence of composite, multimodal strategies that integrate psychosocial factors improve precision applicability management. Neuroimaging techniques like MRI positron emission tomography provide insights into structural functional abnormalities related pain, while electrophysiological methods electroencepholography magnetoencepholography assess dysfunctional processing neuroaxis. Molecular cytokines, proteomics, metabolites, offer diagnostic prognostic potential, though extensive validation is needed. Integrating these with clinical practice can revolutionize management by enabling treatment strategies, improving patient outcomes, potentially reducing healthcare costs. Future directions include development composite biomarker signatures, artificial intelligence, signature integration decision support systems. Rigorous standardization efforts are also necessary ensure clinically useful. Large-scale collaborative research will be vital driving progress this field implementing practice. comprehensive highlights potential transform management, offering hope improved personalization, outcomes.

Language: Английский

Citations

1
Mapping Hand Function with Simultaneous Brain-Spinal Cord Functional MRI DOI Open Access
Valéria Nobre Leal de Souza Oliva, Sandrine Bédard, Merve Kaptan

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Hand motor control depends on intricate brain-spinal cord interactions that regulate muscle activity. function can be disrupted by injury to the brain, spinal cord, and peripheral nerves leading weakness impaired coordination. Functional MRI (fMRI) map motor-related neural activity potentially characterize mechanisms underlying hand diminished Although brain has been extensively studied, remain less explored. Here we use simultaneous fMRI related strength dexterity across central nervous system using force matching finger tapping tasks. This study pioneers of comprehensively function, offering novel insights into coordinated processing system. We performed in 28 right-handed healthy volunteers (age: 40.0 ± 13.8 years, 14 females, males) a 3T GE SIGNA Premier scanner equipped with 21-channel head-neck coil. Participants force-matching task at 10%, 20%, 30% maximum voluntary contraction dynamometer. For task, participants completed button-presses 1 Hz 5-button response pad for three levels: single-digit second digit only (low), all digits sequential order (medium), random (high). Visual cues feedback were provided during tasks.Brain images processed separately FSL Spinal Cord Toolbox, motion correction, physiological noise filtering, spatial normalization standard templates. Subject level maps generated entered group analyses explore both activations deactivations. used mixed effect design voxelwise threshold Z score > 3.10 cluster p < 0.05. fixed 1.64 Region interest (ROI) conducted examine localized changes activation levels. Both tasks elicited sensory regions graded responses left primary (M1), (S1) cortex, right gray matter Deactivation M1 S1 was also present high task. The ROI analysis findings complemented maps. Our provides detailed revealing inhibition patterns regions. Interhemispheric inhibition, reflected deactivation, likely restricts extraneous output unilateral matching, deactivation ventral dorsal horns first evidence areas extends cord. Whether this results from direct descending modulation or interneuronal remains interrogated. These expand our understanding could inform rehabilitation strategies individuals impairments. approach coordination enhancing its modulation. may offer foundation studying dysfunction conditions such as stroke, injury, neurodegenerative diseases.

Language: Английский

Citations

0
Cerebro-spinal somatotopic organization uncovered through functional connectivity mapping DOI Creative Commons
Caroline Landelle, Nawal Kinany, Benjamin De Leener

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 12, 2024

Abstract Somatotopy, the topographical arrangement of sensorimotor pathways corresponding to distinct body parts, is a fundamental feature human central nervous system (CNS). Traditionally, investigations into brain and spinal cord somatotopy have been conducted independently, primarily utilizing stimulations or movements. To date, however, no study has probed somatotopic cerebro-spinal functional connections in vivo humans. In this study, we used simultaneous cervical magnetic resonance imaging (fMRI) demonstrate how coordinated activities these two CNS levels at rest can reveal their shared somatotopy. Using connectivity analyses, mapped preferential correlation patterns between each segment regions, revealing gradient within cortical network. We then validated large-scale organization through complementary data-driven analysis, where effectively identified segments profiles voxels with cortex. These findings underscore potential resting-state fMRI probe minimal experimental burden, holding promise for gaining more comprehensive understanding normal impaired somatosensory-motor functions.

Language: Английский

Citations

2
Towards non-invasive imaging through spinal-cord generated magnetic fields DOI Creative Commons
Meaghan Elizabeth Spedden, George C. O’Neill, Tim M. Tierney

et al.

Frontiers in Medical Technology, Journal Year: 2024, Volume and Issue: 6

Published: Oct. 9, 2024

Non-invasive imaging of the human spinal cord is a vital tool for understanding mechanisms underlying its functions in both healthy and pathological conditions. However, non-invasive presents significant methodological challenge because difficult to access with conventional neurophysiological approaches, due proximity other organs muscles, as well physiological movements caused by respiration, heartbeats, cerebrospinal fluid (CSF) flow. Here, we discuss present state future directions imaging, focus on estimation current flow through magnetic field measurements. We existing cryogenic (superconducting) non-cryogenic (optically-pumped magnetometer-based, OPM) systems, highlight their strengths limitations studying function. While challenges remain, particularly source interference rejection, field-based neuroimaging offers novel avenue advancing research various areas. These include sensorimotor processing, cortico-spinal interplay, brain plasticity during learning recovery from injury, pain perception. Additionally, this technology holds promise diagnosing optimizing treatment disorders.

Language: Английский

Citations

1
Cerebro-spinal somatotopic organization uncovered through functional connectivity mapping DOI Creative Commons
Caroline Landelle, Nawal Kinany, Benjamin De Leener

et al.

Imaging Neuroscience, Journal Year: 2024, Volume and Issue: 2, P. 1 - 14

Published: Jan. 1, 2024

Abstract Somatotopy, the topographical arrangement of sensorimotor pathways corresponding to distinct body parts, is a fundamental feature human central nervous system (CNS). Traditionally, investigations into brain and spinal cord somatotopy have been conducted independently, primarily utilizing stimulations or movements. To date, however, no study has probed somatotopic cerebro-spinal functional connections in vivo humans. In this study, we used simultaneous cervical magnetic resonance imaging (fMRI) demonstrate how coordinated activities these two CNS levels at rest can reveal their shared somatotopy. Using connectivity analyses, mapped preferential correlation patterns between each segment regions, revealing gradient within cortical network. We then validated large-scale organization through complementary data-driven analysis, where effectively identified segments profiles voxels with cortex. These findings underscore potential resting-state fMRI probe minimal experimental burden, holding promise for gaining more comprehensive understanding normal impaired somatosensory-motor functions.

Language: Английский

Citations

0