Brain stimulation, Journal Year: 2024, Volume and Issue: 18(1), P. 15 - 18
Published: Dec. 12, 2024
Language: Английский
Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown, P. 111244 - 111244
Published: Jan. 1, 2025
Language: Английский
Citations
1
Neuromodulation Technology at the Neural Interface, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 1, 2024
Language: Английский
Citations
4
Pain, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 18, 2025
Abstract Transcranial focused ultrasound (tFUS) is an emerging noninvasive neuromodulation technology that has shown great potential in pain modulation. This review systematically elucidates the multilevel biological mechanisms of tFUS neuromodulation, from network-wide effects to cellular and molecular processes, as well broader systemic influences. Preliminary animal model studies have revealed tFUS's ability improve behavioral indicators modulate neural circuit activity under pathological conditions. A small number clinical also suggest may certain benefits improving symptom experience emotional state chronic patients. However, current research generally limitations such sample sizes short follow-up periods. More high-quality are needed verify long-term safety treatment. Overcoming these advancing large-scale translational will help fully exploit application precision medicine provide new treatment options for relief.
Language: Английский
Citations
0
Frontiers in Human Neuroscience, Journal Year: 2025, Volume and Issue: 19
Published: March 24, 2025
Introduction Anhedonic depression is a subtype of characterized by deficits in reward processing. This associated with higher suicide risk and longer depressive episodes, underscoring the importance effective treatments. Anhedonia has also been found to correlate alterations activity several subcortical regions, including caudate head nucleus accumbens. Low intensity focused ultrasound pulsation (LIFUP) an emerging technology that enables non-invasive stimulation these which were previously only accessible surgically-implanted electrodes. Methods double-blinded, sham-controlled study aims investigate effects LIFUP left right accumbens participants anhedonic depression. Participants this protocol will undergo three sessions over span 5–9 days. To LIFUP-related changes, 7-week collects continuous digital phenotyping data, array self-report measures depression, anhedonia, other psychopathology, magnetic resonance imaging (MRI) before after intervention. Primary outcome include Ecological Momentary Assessment, Positive Valence Systems Scale, Patient Health Questionnaire. spectroscopy functional MRI during reward-based tasks at rest. Digital data collected Apple Watch participants' personal iPhones throughout study, includes information about sleep, heart rate, physical activity. Discussion first or depressed subjects. Furthermore, for covers wide potentially affected modalities. As result, help elucidate potential impacts individuals
Language: Английский
Citations
0
Journal of Behavioral and Brain Science, Journal Year: 2025, Volume and Issue: 15(03), P. 81 - 94
Published: Jan. 1, 2025
Language: Английский
Citations
0
Frontiers in Human Neuroscience, Journal Year: 2025, Volume and Issue: 19
Published: April 11, 2025
Since the 1990s, neuromodulation technology has experienced rapid advancements, providing new therapeutic approaches for clinical rehabilitation in neurological disorders. The objective of this study is to utilize CiteSpace and VOSviewer investigate current research status, key topics, future trends field over past decade. Relevant literature published Web Science database from January 1, 2014 June 18, 2024 were retrieved, imported into visualization. was used counties, institutions, authors keywords analyses. presentation visualization analysis co-cited references, clusters bursts. This encompasses a total 1,348 relevant publications, with number publications showing an increasing trend year by year. most significant growth observed between 2020 2021. United States, China Kingdom are three leading countries high output regard. top institutions terms publication volume Harvard Medical School, University Toronto Stanford University. Keyword co-occurrence cluster identified that deep brain stimulation, transcranial magnetic direct focused ultrasound stimulation widely central nerve techniques neuromodulation. treatment intractable chronic pain also emerged as focus within techniques. recent bursts included such recovery, movement, nucleus, modeling plasticity, suggesting will be centered on these areas. In conclusion, garnering attention researchers currently diseases. Future expected delve deeper, particularly exploring structure targets restoring motor function based neuroplasticity theory.
Language: Английский
Citations
0
Molecular Psychiatry, Journal Year: 2025, Volume and Issue: unknown
Published: April 24, 2025
Mood, anxiety, and trauma-related disorders (MATRDs) are highly prevalent comorbid. A sizable number of patients do not respond to first-line treatments. Non-invasive neuromodulation is a second-line treatment approach, but current methods rely on cortical targets indirectly modulate subcortical structures, e.g., the amygdala, implicated in MATRDs. Low-intensity transcranial focused ultrasound (tFUS) non-invasive technique for direct neuromodulation, its safety, feasibility, promise as potential largely unknown. In target engagement study, magnetic resonance imaging (MRI)-guided tFUS left amygdala was administered during functional MRI (tFUS/fMRI) test acute modulation blood oxygenation level dependent (BOLD) signal double-blind, within-subject, sham-controlled design with MATRDs (N = 29) healthy comparison subjects 23). an unblinded trial, same then underwent 3-week daily (15 sessions) MRI-guided repetitive (rtFUS) examine symptom change, change reactivity emotional faces. Active vs. sham tFUS/fMRI reduced, average, BOLD produced patient-related differences hippocampal insular responses. rtFUS well-tolerated no serious adverse events. There were significant reductions primary outcome (Mood Anxiety Symptom Questionnaire General Distress subscale; p 0.001, Cohen's d 0.77), secondary outcomes (Cohen's 0.43-1.50), activation stimuli. Findings provide initial evidence capability function, safety feasibility MATRDs, motivate double-blind randomized controlled trials efficacy.ClinicalTrials.gov registration: NCT05228964.
Language: Английский
Citations
0
Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15
Published: Nov. 19, 2024
Substance use disorder (SUD) is a persistent public health issue that necessitates the exploration of novel therapeutic interventions. Low-intensity focused ultrasound (LIFU) promising modality for precise and invasive modulation brain activity, capable redefining landscape SUD treatment. The review overviews effective LIFU neuromodulatory parameters molecular mechanisms, focusing on reward pathways in key regions animal human models. Integration with established therapeutics holds promise augmenting treatment outcomes SUD. current research examines LIFU's efficacy reducing cravings withdrawal symptoms. shows cravings, modulating circuitry, addressing interoceptive dysregulation emotional distress. Selecting optimal parameters, encompassing frequency, burst patterns, intensity, pivotal balancing safety. However, inconsistencies empirical findings warrant further physiological action long-term effects. Collaborative interdisciplinary investigations are imperative to fully realize potential revolutionizing paradigms enhancing patient outcomes.
Language: Английский
Citations
2
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: May 31, 2024
Abstract This research investigates whether ventricular-focused ultrasound stimulation (ventricle-FUS) can serve as an effective control in studies using transcranial FUS, a non-invasive technology for brain modulation. FUS has notable potential therapeutic applications but requires robust to accurately assess its effects. We evaluated the effectiveness of ventricle-FUS, active, non-cerebrum research, comparing it sham stimulation. conducted comprehensive assessment employing both questionnaires and multiple neuroimaging metrics such grey matter white volumes, functional connectivity. Ventricle-FUS did not alter any these metrics, thereby successfully retaining auditory, somatosensory, experiential elements without affecting structure or function. Importantly, participants were unable distinguish they received ventricle-FUS FUS. Our findings confirm that establishes reliable approach crucial advancing applications.
Language: Английский
Citations
1
NeuroImage, Journal Year: 2024, Volume and Issue: 301, P. 120866 - 120866
Published: Sept. 24, 2024
Language: Английский
Citations
1