Novel NIBS in psychiatry: Unveiling TUS and TI for research and treatment

Brain and Neuroscience Advances, Journal Year: 2025, Volume and Issue: 9

Published: March 1, 2025

Mental disorders pose a significant global burden and constitute major cause of disability worldwide. Despite strides in treatment, substantial number patients do not respond adequately, underscoring the urgency for innovative approaches. Traditional non-invasive brain stimulation techniques show promise, yet grapple with challenges regarding efficacy specificity. Variations mechanistic understanding reliability among methods are common, limited spatial precision physical constraints hindering ability to target subcortical areas often implicated disease aetiology. Novel such as transcranial ultrasonic temporal interference have gained notable momentum recent years, possibly addressing these shortcomings. Transcranial (TUS) offers exceptional deeper penetration compared conventional electrical magnetic techniques. Studies targeting diverse array regions shown its potential affect neuronal excitability, functional connectivity symptoms psychiatric depressive disorder. Nevertheless, planning acoustic interactions skull must be tackled widespread adoption research potentially clinical settings. Similar stimulation, (TI) traditional albeit requiring comparatively higher current equivalent neural effects. Promising still sparse highlights TI’s selectively modulate activity, showing utility psychiatry. Overall, like only open new avenues but also hold effective treatments However, realising their full necessitates practical optimising application effectively.

Language: Английский

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Mechanical Microvibrations as a Basis Organization of Functional Cells Groups

Journal of Behavioral and Brain Science, Journal Year: 2025, Volume and Issue: 15(03), P. 81 - 94

Published: Jan. 1, 2025

Language: Английский

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Transcranial focused ultrasound targeting the default mode network for the treatment of depression

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 16

Published: April 4, 2025

Introduction Up to 50% of individuals fail respond current depression treatments. Repetitive negative thought and default mode network hyperconnectivity are central in can potentially be targeted using novel neuromodulation techniques. This community-based study assessed whether a treatment non-invasive transcranial focused ultrasound targeting the decrease symptoms repetitive thought, improve quality life. Methods Study recruitment began August 2023 ended February 2024. Twenty aged 18 – 50 were enrolled from among 247 screened. Exclusion criteria included history psychosis/mania, acute suicidality, MRI contraindications, pregnancy, medical neurological factors that may complicate diagnosis or brain function. Participants completed up three weeks (11 sessions) anterior medial prefrontal cortex; ten minutes per session. Depression severity (Beck Inventory II Hamilton Rating Scale), (Perseverative Thinking Questionnaire), life (World Health Organization Quality Life Scale) outcomes. Results sample was young (mean 30.4 years ± 10.0), predominantly female (75%), with moderate severe high comorbidity. Fifty percent participants endorsed psychiatric medication use. Ten subjects dropped out due time constraints. Significant decreases observed over course on self-report, 10.9 (p < 0.001, CI = -13.55, -7.92) interview ratings, 4.2 -5.85, -2.62), as well significant 8.4 <0.001, -10.55, -6.03). Improvements physical psychological well-being also treatment, 7.2 3.64, 10.63) 11.2 7.79, 14.49), respectively, improvements environment satisfaction, 5.0 =0.001, 2.24, 7.56). Discussion Non-invasive holds promise for depression, however, future work including control arms is required ascertain its causal role depression. Clinical trial registration https://clinicaltrials.gov/study/NCT06320028intr=Ultrasound&cond=depression&locStr=Arizona&country=United%20States&state=Arizona&rank=1 , identifier NCT06320028.

Language: Английский

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The Default Mode Network and inner time consciousness

Current Opinion in Behavioral Sciences, Journal Year: 2025, Volume and Issue: 63, P. 101524 - 101524

Published: April 22, 2025

Language: Английский

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Deconstructing the self and reshaping perceptions: An intensive whole-brain 7T MRI case study of the stages of insight during advanced investigative insight meditation

NeuroImage, Journal Year: 2024, Volume and Issue: unknown, P. 120968 - 120968

Published: Dec. 1, 2024

The stages of insight (SoI) are a series psychological realizations experienced through advanced investigative meditation (AIIM). SoI provide powerful structured framework AIIM for understanding and evaluating insight-based meditative development changes in perception, experiences self, cognition, emotional processing. Yet, the neurophenomenology remains unstudied due to methodological difficulties, rarity suitable practitioners, dominant research emphasis on attention-based practices. We investigated an intensively sampled adept meditator case study (4 hr 7T fMRI collected 26 runs with concurrent phenomenology) who performed rated specific aspects experience immediately thereafter. Linear mixed models correlations were used examine relations among cortex, subcortex, brainstem, cerebellum, phenomenology. identified distinctive whole-brain activity patterns associated SoI, that different from two non-meditative control states. consistently deactivated regions implicated self-related processing, including medial prefrontal cortex temporal poles, while activating awareness parietal visual cortices, caudate, several brainstem nuclei, cerebellum. Patterns brain related affective processing phenomenology also identified. Our presents first neurophenomenological evidence shifts deconstructs perception conceptualization, increases general perceptual sensitivity acuity. provides as foundation investigative, particular.

Language: Английский

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Enhancing Equanimity with Non-Invasive Brain Stimulation: A Novel Framework for Mindfulness Interventions

Biological Psychiatry Cognitive Neuroscience and Neuroimaging, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

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